Safe harbor loci

ABSTRACT

Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a divisional of U.S. application Ser. No. 17/716,816 filed Apr. 8, 2022, allowed, which is a divisional of U.S. application Ser. No. 17/239,484 filed Apr. 23, 2021, allowed, which claims priority to and the benefit of U.S. Provisional Patent Application No. 63/141,926, filed on Jan. 26, 2021, and U.S. Provisional Patent Application No. 63/105,834, filed on Oct. 26, 2020, the entire contents of which are incorporated by reference herein for all purposes.

SEQUENCE LISTING

The instant application contains a Sequence Listing which will be submitted via Patent Center and is hereby incorporated by reference in its entirety. Said XML copy, created on Aug. 29, 2023, is named ANB-203D2_SL.xml and is 845,305 bytes in size.

BACKGROUND

Cancer continues to present a significant clinical burdSen despite the substantial research efforts and scientific advances in cancer therapies. Blood and bone marrow cancers are frequently diagnosed cancer types, including multiple myelomas, leukemia, and lymphomas. Current treatment options for these cancers are not effective for all patients and/or can have substantial adverse side effects. Other types of cancer also remain challenging to treat using existing therapeutic options. Cancer immunotherapies are a promising solution because they can be highly specific, allowing for increased therapeutic effectiveness and the mitigation of side effects.

Genetically engineered immune cell therapy is a growing field with promising applications for the treatment of diseases including, but not limited to, cancer. Through the alteration of coding and/or non-coding genomic regions, researchers are identifying transgenes and insertion sites within cells that facilitate, for example, enhanced cell function, arrest cell growth, induced cell death, and tumor size/volume reduction. The identification of safe harbor sites (SHS) has improved outcomes of genome-engineering therapies. Well known SHS include the AAVS1 adeno-associated virus insertion site on chromosome 19, the human homolog of the murine Rosa26 locus, and the CCR5 chemokine receptor gene—the absence of which confers HIV resistance. (See, for example, Pellenz et al., 2018, the relevant disclosures of which are herein incorporated by reference). However, there is still a need for improved guidelines for gene editing therapies and additional SHS to address challenges such as poor knock-in (KI) efficiency, insertional oncogenesis, unstable and/or anomalous expression of transgenes and/or adjacent genes, etc.

SUMMARY

The present disclosure is directed, inter alia, to safe harbor loci that exhibit high knock-in efficiency and stable expression of their transgenes. These safe harbor loci can be used to alter T cells for immunotherapy. These safe harbor loci are useful for the treatment of various diseases, including cancer.

In one aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an endogenous promoter. In another aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an exogenous promoter.

In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.

In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93.

In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR).

In another aspect, the present disclosure provides a composition comprising the engineered cell as described herein and a pharmaceutical excipient.

In another aspect, the present disclosure provides a guide ribonucleic acids (gRNA) for editing a cell at a safe harbor locus, wherein gRNA comprises any one of the sgRNA sequences in Table 4.

In some embodiments, the gRNA comprises any one of SEQ ID NOS:1-120. In some embodiments, the gRNA comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor.

In another aspect, the present disclosure provides a method of editing a cell having chromosomal DNA, comprising inserting at least one sequence encoding a transgene within a safe harbor locus in the chromosomal DNA of the cell, wherein the safe harbor locus is any one or more of the sgRNA target loci provided in Table 4.

In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.

In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93.

In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR). In some embodiments, the at least one sequence comprises an exogenous promoter and the exogenous promoter is operably linked to the transgene. In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell progenitor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion. In some embodiments, the at least one sequence is inserted using one or more guide ribonucleic acids (gRNAs) and one or more Cas9 endonucleases.

In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.

In another aspect, the present disclosure provides a method of editing a T cell, comprising contacting a T cell with one or more guide ribonucleic acids (gRNAs), at least one sequence encoding a transgene, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within a safe harbor locus, wherein the safe harbor locus is selected from any one or more of the sgRNA target loci in Table 4.

In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.

In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.

In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93

In another aspect, the present disclosure provides an ex vivo method of obtaining an engineered cell or population thereof, comprising (a) obtaining a cell; and (b) genetically modifying the cell by inserting at least one sequence encoding a transgene within a safe harbor locus, wherein the safe harbor locus is selected from any one of the sgRNA target loci in Table 4.

In some embodiments, obtaining the cell comprises: (i) collecting a tissue sample from a subject, (ii) isolating the cells from the tissue samples, and (iii) culturing the cells in vitro. In some embodiments, the tissue sample is a blood sample. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion.

In some embodiments, the genetically modifying in step (b) comprises contacting the cell with one or more guide ribonucleic acids (gRNAs), the at least one sequence, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within the safe harbor locus. In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4.

In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR). In some embodiments, the at least one sequence comprises an exogenous promoter and the exogenous promoter is operably linked to the transgene. In some embodiments, the exogenous promoter is an EF1a promoter.

In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising administering to the subject an effective amount of an engineered cell as described herein, a population thereof, or a composition as described herein. In some embodiments, the cell, the population thereof, or the composition is administered to the subject by infusion.

In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising (a) conducting any one of the methods described supra; and (b) administering to the subject an effective amount of a composition comprising the cell or a population thereof. In some embodiments, the composition is administered to the subject by infusion. In some embodiments, the disease is cancer. In some embodiments, the disease is blood cancer.

In another aspect, the present disclosure provides a method of identifying a safe harbor locus, comprising: (a) identifying genes or non-coding regions in a chromosome that are above a threshold level for expression across developmental cell states and/or a threshold level for accessibility of chromatin; (b) generating a linear model that correlates the gene or non-coding region from step (a) with knock-in (KI) efficiency and estimates the KI efficiency of any gene or coding region on the chromosome; and (c) selecting the safe harbor locus based on threshold parameters; wherein the safe harbor locus is selected for insertion of at least one sequence encoding a transgene within a cell.

In some embodiments, the threshold parameters include one or more of: stable expression of a transgene, knockout of the gene confers benefit to the function of the cell, no known function within the cell, stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene. In some embodiments, the stable expression of a transgene at the safe harbor locus is less than or equal to 2-fold expression change over the course of at least 1, 2, 3, 4, 5, 6, or 7 days, and wherein expression change is measured by mean fluorescence intensity of a reporter gene encoded by the at least one sequence. In some embodiments, the accessibility of chromatin is measured using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). In some embodiments, the level of expression across developmental cell states is measured using RNA sequencing (RNA-seq).

In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the linear model has a coefficient of determination (R² value) of at least 30%.

In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein insertion within the safe harbor locus increase cell cytotoxicity of diseased cells.

In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein knock-in efficiency at the safe harbor locus is increased relative to other locations along the chromosome.

BRIEF DESCRIPTION OF THE DRAWINGS

These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:

FIG. 1 includes a schematic depicting the methodology used to identify safe harbor loci in the present disclosure, in some embodiments.

FIGS. 2A-2C include schematic depicting 3 top safe harbor loci known in the art: AAVS1 (FIG. 2A), CCR5 (FIG. 2B), and Rosa26 (FIG. 2C). The figures were retrieved from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIG. 3 includes a schematic outlining the data provided in Roth, T. L., et al. 2019. Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIGS. 4A-4B include heatmaps with samples clustered based on activation status and cell type, generated with processed RNA-seq data. FIG. 4A includes a heatmap of samples generated with processed RNA-seq data. FIG. 4B includes a heatmap sample generated with processed RNA-seq data, showing the clustering of ˜20 k genes.

FIGS. 5A-5B include plots generated using processed RNA-seq data. FIG. 5A includes a plot showing direct correlation between transcript expression data from Roth, T. L., et al. 2019 and transcript expression data generated by the inventors of the present disclosure. FIG. 5B includes a heatmap showing clusters of the top 10% expressed genes.

FIG. 6 includes a heatmap of samples generated with processed ATAC-seq data.

FIGS. 7A-7B includes plots depicting the signal enrichment at transcription start sites (TSS) (FIG. 7A) and peak size distribution (FIG. 7B), generated with processed ATAC-seq data for coding regions.

FIG. 8 includes a plot depicting the open chromatin regions around the TRAC locus.

FIG. 9 includes a plot depicting KI (knock-in) efficiency for coding regions/genes with GFP as a reporter.

FIG. 10 includes a plot depicting KI efficiency for coding regions/genes with tNGFR as a reporter.

FIG. 11 includes plots showing scaled KI efficiency for 90 genes vs d2 (day-2) RNA-seq data, d4 (day-4) RNA-seq data and ATAC-seq data, utilized for the predictive linear model.

FIG. 12 includes a plot showing chromatin accessibility for a top candidate non-coding region, measured using ATAQ sequencing.

FIG. 13A includes plots showing the cell counts for GFP controls used for the evaluation of candidate KI loci. FIG. 13B includes pmax (GFP_high) readings for GFP controls used for the evaluation of candidate KI loci.

FIG. 14A includes plots showing the maximum episomal GFP expression (GFP_high) readings for non-targeting controls. FIG. 14B includes the cell count for non-targeting controls from donors 1, 2, and 3.

FIG. 15 includes the cell count and maximum GFP expression (GFP_high) readings for WT controls.

FIG. 16 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 17 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an EF1a promoter.

FIG. 18 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79 to target a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 19 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.

FIG. 20 includes plots showing TCR (T cell receptor) vs. GFP among all donors and time points when using sgRNA79, and the construct is driven by an endogenous promoter.

FIG. 21 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA79 and the construct is driven by an exogenous promoter.

FIG. 22 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 23 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.

FIG. 24 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an endogenous promoter.

FIG. 25 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an exogenous promoter.

FIG. 26 includes plots illustrating potential sources of variation (e.g., edge effects and electroporation errors) observed between replicates and donors.

FIG. 27 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to inherent differences between donors.

FIG. 28 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to gating errors.

FIG. 29 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with endogenous promoters.

FIG. 30 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with the EF1a promoter.

FIGS. 31A-31C include plots showing all the significant KI loci (top KI loci) as evaluated with endogenous and EF1a promoters. FIG. 31A includes a plot showing that the expression from the EF1a promoter was approximately 10 times higher than expression from an endogenous promoter. FIG. 31B shows the top KI loci ranked by GFP MFI at week 3. FIG. 31C shows the top integration loci ranked by GFP MFI (at weeks 3 and 4; donors 1-3).

FIG. 32A includes a plot showing some target loci and their measured transgene expression levels. FIG. 32B includes plots showing the transgene (Prime Receptor (PrimeR)) and TCR expression for the control and insertion at GS94, GS102 and TRAC loci.

FIG. 33A includes a plot showing the PrimeR levels measured for the indicated integration sites. FIG. 33B includes a schematic showing the GS94 integration site on Chromosome 11.

FIG. 34A includes plots showing CAR induction and primeR expression of engineered T cells after 48 hours of coculturing with K562-CD19 cells. FIG. 34B includes plots showing the cytotoxity and cytokine secretion levels for engineered T cells 48 hours of coculturing with K562-CD19/MSLN cells.

FIG. 35A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytotoxicity. FIG. 35B includes plots showing the measured cytotoxicity for engineered T cells cocultured for 48 hours with the K562 CD19+/MSLN+ or K562 CD19−/MSLN+ cells.

FIG. 36A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytokine secretion. FIG. 36B includes plots showing the measured cytokine levels for engineered T cells cocultured for 48 hours with K562 CD19+/MSLN+ cells.

FIG. 37 includes a schematic showing the in vitro experiment conducted to determin the effect of integration site on primeR-independent CAR expression. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimulation of the engineered T cells. “EP” refers to electroporation.

FIGS. 38A and 38B include plots showing the stability of PrimeR expression over time when using the indicated integration sites. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimualation of the engineered T cells. “EP” refers to electroporation. In FIG. 38B, the PrimeR expression is normalized to the expression from using the TRAC integration site.

FIG. 39A includes a schematic showing the iGuide-Seq assay technique. FIG. 39B includes a plot showing the on-target efficiency, using iGuide Seq assay, for the indicated integration sites. FIG. 39C includes schematics from the iGuide-Seq analysis showing that GS94 had no reproducible putatitve off-targets across two donors FIG. 39C discloses SEQ ID NOS 312-322, 312-313, and 323-331, respectively, in order of appearance.

FIG. 40 includes a schematic showing the iGuide-Seq workflow and data.

FIG. 41 includes a plot showing rhAmp-seg™ analysis of putative off-target sites identified by iGUIDE-seq and Elevation prediction.

FIG. 42 includes plots showing RNA-seq analysis of cells with GS94, GS102 and TRAC knock-in of CD19/MSLN circuits. Scatterplot of gene expression in cells with integration at the GS94 locus (y-axis) vs cells with integration at either the TRAC or the GS102 locus (x-axis) in two donors. The yellow dots correspond to ETS1 and FLI1. In blue are the genes that were found to be differentially expressed using edgeR (fold-change >0, FDR-corrected p-value <0.01, average counts-per-million across compared conditions at least 2).

FIG. 43 includes plots showing the absence of cytokine-independent growth in cells with CD19/MSLN circuit KI at GS94.

DETAILED DESCRIPTION

The present disclosure provides safe harbor loci and methods for identifying safe harbor loci that exhibit high integration efficiency (e.g., high knock-in (KI) efficiency), high and constant levels of transgene expression, and such benefits independent of T cell activation/differentiation state. In some embodiments, the safe harbor loci also exhibit minimal to no disruption to T cell function and/or capacity for product manufacturing. In some embodiments, these loci are useful for effective and safe integration and expression of transgenes in T cells (e.g. in CAR T therapies). In some embodiments, the methods described herein can be used for the identification of safe harbor loci for insertion of transgenes in other types of cells.

FIG. 1 illustrates the overall approach that the inventors of the present disclosure used to identify safe harbor loci. In some embodiments, the present disclosure provides a method comprising the identification of genes within a genome and non-coding regions with sustained expression in a treatment cell (e.g. T cell) and using a predictive model of KI efficiency as a function of T cell chromatic state and computational analysis to predict candidate integration sites. The method further comprises evaluating the candidate integration sites for actual KI efficiency, sustained levels of transgene expression of a transgene, and minimal disruption to the treatment cell phenotype (e.g., T cell function and/or capacity for treatment product expansion and manufacturing). In some embodiments, the safe harbor loci allow for integration of a transgene driven by an endogenous promoter. In some embodiments, the safe harbor loci allow for integration of a transgene driven by an exogenous promoter (e.g. EF1a promoter).

To facilitate an understanding of the present disclosure, a number of terms and phrases are defined below. Unless otherwise defined herein, scientific and technical terms used in this application shall have the meanings that are commonly understood by those of ordinary skill in the art. Generally, nomenclature used in connection with, and techniques of pharmacology, cell and tissue culture, molecular biology, cell and cancer biology, neurobiology, neurochemistry, virology, immunology, microbiology, genetics and protein and nucleic acid chemistry, described herein, are those well-known and commonly used in the art. In case of conflict, the present specification, including definitions, will control.

Unless otherwise defined, all terms of art, notations and other scientific terminology used herein are intended to have the meanings commonly understood by those of skill in the art. In some cases, terms with commonly understood meanings are defined herein for clarity and/or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a difference over what is generally understood in the art. The techniques and procedures described or referenced herein are generally well understood and commonly employed using conventional methodologies by those skilled in the art, such as, for example, the widely utilized molecular cloning methodologies described in Sambrook et al., Molecular Cloning: A Laboratory Manual 4th ed. (2012) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. As appropriate, procedures involving the use of commercially available kits and reagents are generally carried out in accordance with manufacturer-defined protocols and conditions unless otherwise noted.

As used herein, the singular forms “a,” “an,” and “the” include the plural referents unless the context clearly indicates otherwise. The terms “include,” “such as,” and the like are intended to convey inclusion without limitation, unless otherwise specifically indicated.

As used herein, the term “comprising” also specifically includes embodiments “consisting of” and “consisting essentially of” the recited elements, unless specifically indicated otherwise.

The term “about” indicates and encompasses an indicated value and a range above and below that value. In certain embodiments, the term “about” indicates the designated value ±10%, ±5%, or ±1%. In certain embodiments, where applicable, the term “about” indicates the designated value(s) ±one standard deviation of that value(s).

As used herein, the term “gene” refers to the basic unit of heredity, consisting of a segment of DNA arranged along a chromosome, which codes for a specific protein or segment of protein. A gene typically includes a promoter, a 5′ untranslated region, one or more coding sequences (exons), optionally introns, a 3′ untranslated region. The gene may further comprise a terminator, enhancers and/or silencers.

As used herein, the term “locus” refers to a specific, fixed physical location on a chromosome where a gene or genetic marker is located.

As used herein, the term “target locus” refers to a locus on a chromosome within which a safe harbor locus can be used for the insertion of a sequence. A target locus can consist of multiple potential safe harbor loci (integration sites). Examples of target loci are provided in Table 4, as sgRNA target loci. The notation used for the sgRNA target loci in Table 4 refers to the genomic region of the target locus, defined by the chromosome of the target locus and the coordinate range for that target locus. For example, chr10:33130000-33140000 refers to a target locus on Chr10 (chromosome 10) starting from coordinate 33130000 and ending with coordinate 33140000.

The term “safe harbor locus” refers to a locus at which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes. These safe harbor loci are also referred to as safe harbor sites (SHS). As used herein, a safe harbor locus refers to an “integration site” or “knock-in site” at which a sequence encoding a transgene, as defined herein, can be inserted. In some embodiments the insertion occurs with replacement of a sequence that is located at the integration site. In some embodiments, the insertion occurs without replacement of a sequence at the integration site. Examples of integration sites contemplated are provided in Table 4.

As used herein, the term “insert” refers to a nucleotide sequence that is integrated (inserted) at a safe harbor site. The insert can be used to refer to the genes or genetic elements that are incorporated at the safe harbor site using, for example, homology-directed repair (HDR) CRISPR/Cas9 genome-editing or other methods for inserting nucleotide sequences into a genomic region known to those of ordinary skill in the art.

The “CRISPR/Cas” system refers to a widespread class of bacterial systems for defense against foreign nucleic acid. CRISPR/Cas systems are found in a wide range of eubacterial and archaeal organisms. CRISPR/Cas systems include type I, II, and III sub-types. Wild-type type II CRISPR/Cas systems utilize an RNA-mediated nuclease, Cas9 in complex with guide and activating RNA to recognize and cleave foreign nucleic acid. Guide RNAs having the activity of both a guide RNA and an activating RNA are also known in the art. In some cases, such dual activity guide RNAs are referred to as a small guide RNA (sgRNA).

Cas9 homologs are found in a wide variety of eubacteria, including, but not limited to bacteria of the following taxonomic groups: Actinobacteria, Aquificae, Bacteroidetes-Chlorobi, Chlamydiae-Verrucomicrobia, Chlroflexi, Cyanobacteria, Firmicutes, Proteobacteria, Spirochaetes, and Thermotogae. An exemplary Cas9 protein is the Streptococcus pyogenes Cas9 protein. Additional Cas9 proteins and homologs thereof are described in, e.g., Chylinksi, et al., RNA Biol. 2013 May 1; 10(5): 726-737; Nat. Rev. Microbiol. 2011 June; 9(6): 467-477; Hou, et al., Proc Natl Acad Sci USA. 2013 Sep. 24; 110(39):15644-9; Sampson et al., Nature. 2013 May 9; 497(7448):254-7; and Jinek, et al., Science. 2012 Aug. 17; 337(6096):816-21. The Cas9 nuclease domain can be optimized for efficient activity or enhanced stability in the host cell.

As used herein, the term “Cas9” refers to an RNA-mediated nuclease (e.g., of bacterial or archeal orgin, or derived therefrom). Exemplary RNA-mediated nuclases include the foregoing Cas9 proteins and homologs thereof, and include but are not limited to, CPF1 (See, e.g., Zetsche et al., Cell, Volume 163, Issue 3, p 759-771, 22 Oct. 2015). Similarly, as used herein, the term “Cas9 ribonucleoprotein” complex and the like refers to a complex between the Cas9 protein, and a crRNA (e.g., guide RNA or small guide RNA), the Cas9 protein and a trans-activating crRNA (tracrRNA), the Cas9 protein and a small guide RNA, or a combination thereof (e.g., a complex containing the Cas9 protein, a tracrRNA, and a crRNA guide RNA).

As used herein, the terms “T lymphocyte” and “T cell” are used interchangeably and refer to cells that have completed maturation in the thymus, and identify certain foreign antigens in the body. The terms also refer to the major leukocyte types that have various roles in the immune system, including activation and deactivation of other immune cells. The T cell can be any T cell such as a cultured T cell, e.g., a primary T cell, or a T cell derived from a cultured T cell line, e.g., a Jurkat, SupT1, etc., or a T cell obtained from a mammal. The T cell can be a CD3+ cell. The T cell can be any type of T cell, CD4+/CD8+ double positive T cells, CD4+ helper T cells (e.g. Th1 and Th2 cells), CD8+ T cells (e.g. cytotoxic T cells), peripheral Including but not limited to blood mononuclear cells (PBMC), peripheral blood leukocytes (PBL), tumor infiltrating lymphocytes (TIL), memory T cells, naive T cells, regulatory T cells, γδ T cells, etc. It can be any T cell at any stage of development. Additional types of helper T cells include Th3 (Treg) cells, Th17 cells, Th9 cells, or Tfh cells. Additional types of memory T cells include cells such as central memory T cells (Tcm cells), effector memory T cells (Tem cells and TEMRA cells). A T cell can also refer to a genetically modified T cell, such as a T cell that has been modified to express a T cell receptor (TCR) or a chimeric antigen receptor (CAR). T cells can also be differentiated from stem cells or progenitor cells.

“CD4+ T cells” refers to a subset of T cells that express CD4 on their surface and are associated with a cellular immune response. CD4+ T cells are characterized by a post-stimulation secretion profile that can include secretion of cytokines such as IFN-γ, TNF-α, IL-2, IL-4 and IL-10. “CD4” is a 55 kD glycoprotein originally defined as a differentiation antigen on T lymphocytes, but was also found on other cells including monocytes/macrophages. The CD4 antigen is a member of the immunoglobulin superfamily and has been implicated as an associative recognition element in MHC (major histocompatibility complex) class II restricted immune responses. On T lymphocytes, the CD4 antigen defines a helper/inducer subset.

“CD8+ T cells” refers to a subset of T cells that express CD8 on their surface, are MHC class I restricted, and function as cytotoxic T cells. The “CD8” molecule is a differentiation antigen present on thymocytes, as well as on cytotoxic and suppressor T lymphocytes. The CD8 antigen is a member of the immunoglobulin superfamily and is an associative recognition element in major histocompatibility complex class I restriction interactions.

As used herein, the term “ex vivo” generally includes experiments or measurements made in or on living tissue, preferably in an artificial environment outside the organism, preferably with minimal differences from natural conditions.

As used herein, the term “construct” refers to a complex of molecules, including macromolecules or polynucleotides.

As used herein, the term “integration” refers to the process of stably inserting one or more nucleotides of a construct into the cell genome, i.e., covalently linking to a nucleic acid sequence in the chromosomal DNA of the cell. It may also refer to nucleotide deletions at a site of integration. Where there is a deletion at the insertion site, “integration” may further include substitution of the endogenous sequence or nucleotide deleted with one or more inserted nucleotides.

As used herein, the term “exogenous” refers to a molecule or activity that has been introduced into a host cell and is not native to that cell. The molecule can be introduced, for example, by introduction of the encoding nucleic acid into host genetic material, such as by integration into a host chromosome, or as non-chromosomal genetic material, such as a plasmid. Thus, the term, when used in connection with expression of an encoding nucleic acid, refers to the introduction of the encoding nucleic acid into a cell in an expressible form. The term “endogenous” refers to a molecule or activity that is present in a host cell under natural, unedited conditions. Similarly, the term, when used in connection with expression of the encoding nucleic acid, refers to expression of the encoding nucleic acid that is contained within the cell and not introduced exogenously.

As used herein, a “polynucleotide donor construct” refers to a nucleotide sequence (e.g. DNA sequence) that is genetically inserted into a polynucleotide and is exogenous to that polynucleotide. The polynucleotide donor construct is transcribed into RNA and optionally translated into a polypeptide. The polynucleotide donor construct can include prokaryotic sequences, cDNA from eukaryotic mRNA, genomic DNA sequences from eukaryotic (e.g., mammalian) DNA, and synthetic DNA sequences. For example, the polynucleotide donor construct can be a miRNA, shRNA, natural polypeptide (i.e., a naturally occurring polypeptide) or fragment thereof or a variant polypeptide (e.g. a natural polypeptide having less than 100% sequence identity with the natural polypeptide) or fragments thereof.

As used herein, the term “transgene” refers to a polynucleotide that has been transferred naturally, or by any of a number of genetic engineering techniques from one organism to another. It is optionally translated into a polypeptide. It is optionally translated into a recombinant protein. A “recombinant protein” is a protein encoded by a gene—recombinant DNA—that has been cloned in a system that supports expression of the gene and translation of messenger RNA (see expression system). The recombinant protein can be a therapeutic agent, e.g. a protein that treats a disease or disorder disclosed herein. As used, transgene can refer to a polynucleotide that encodes a polypeptide. A transgene can also refer to a non-encoding sequence, such as, but not limited to shRNAs, miRNAs, and miRs.

The terms “protein,” “polypeptide,” and “peptide” are used herein interchangeably.

As used herein, the term “operably linked” refers to the binding of a nucleic acid sequence to a single nucleic acid fragment such that one function is affected by the other. For example, if a promoter is capable of affecting the expression of a coding sequence or functional RNA (i.e., the coding sequence or functional RNA is under transcriptional control by the promoter), the promoter is operably linked thereto. Coding sequences can be operably linked to control sequences in both sense and antisense orientation.

As used herein, the term “developmental cell states” refers to, for example, states when the cell is inactive, actively expressing, differentiating, senescent, etc. developmental cell state may also refer to a cell in a precursor state (e.g., a T cell precursor).

As used, the term “encoding” refers to a sequence of nucleic acids which codes for a protein or polypeptide of interest. The nucleic acid sequence may be either a molecule of DNA or RNA. In preferred embodiments, the molecule is a DNA molecule. In other preferred embodiments, the molecule is a RNA molecule. When present as a RNA molecule, it will comprise sequences which direct the ribosomes of the host cell to start translation (e.g., a start codon, ATG) and direct the ribosomes to end translation (e.g., a stop codon). Between the start codon and stop codon is an open reading frame (ORF). Such terms are known to one of ordinary skill in the art.

The term “inserting” refers to a manipulation of a nucleotide sequence to introduce a non-native sequence. This is done, for example, via the use of restriction enzymes and ligases whereby the DNA sequence of interest, usually encoding the gene of interest, can be incorporated into another nucleic acid molecule by digesting both molecules with appropriate restriction enzymes in order to create compatible overlaps and then using a ligase to join the molecules together. One skilled in the art is very familiar with such manipulations and examples may be found in Sambrook et al. (Sambrook, Fritsch, & Maniatis, “Molecular Cloning: A Laboratory Manual”, 2nd ed., Cold Spring Harbor Laboratory, 1989), which is hereby incorporated by reference in its entirety including any drawings, figures and tables.

As used herein, the term “subject” refers to a mammalian subject. Exemplary subjects include humans, monkeys, dogs, cats, mice, rats, cows, horses, camels, goats, rabbits, pigs and sheep. In certain embodiments, the subject is a human. In some embodiments the subject has a disease or condition that can be treated with an engineered cell provided herein or population thereof. In some aspects, the disease or condition is a cancer.

As used herein, the term “promoter” refers to a nucleotide sequence (e.g. DNA sequence) capable of controlling the expression of a coding sequence or functional RNA. The promoter sequence consists of proximal and more distal upstream elements, the latter elements often referred to as enhancers. A promoter can be derived from natural genes in its entirety, can be composed of different elements from different promoters found in nature, and/or may comprise synthetic DNA segments. A promoter, as contemplated herein, can be endogenous to the cell of interest or exogenous to the cell of interest. It is appreciated by those skilled in the art that different promoters can induce gene expression in different tissue or cell types, or at different developmental stages, or in response to different environmental conditions. As is known in the art, a promoter can be selected according to the strength of the promoter and/or the conditions under which the promoter is active, e.g., constitutive promoter, strong promoter, weak promoter, inducible/repressible promoter, tissue specific Or developmentally regulated promoters, cell cycle-dependent promoters, and the like.

A promoter can be an inducible promoter (e.g., a heat shock promoter, tetracycline-regulated promoter, steroid-regulated promoter, metal-regulated promoter, estrogen receptor-regulated promoter, etc.). The promoter can be a constitutive promoter (e.g., CMV promoter, UBC promoter). In some embodiments, the promoter can be a spatially restricted and/or temporally restricted promoter (e.g., a tissue specific promoter, a cell type specific promoter, etc.). See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.

Gene editing, as contemplated herein, may involve a gene (or nucleotide sequence) knock-in or knock-out. As used herein, the term “knock-in” refers to an addition of a DNA sequence, or fragment thereof into a genome. Such DNA sequences to be knocked-in may include an entire gene or genes, may include regulatory sequences associated with a gene or any portion or fragment of the foregoing. For example, a polynucleotide donor construct encoding a recombinant protein may be inserted into the genome of a cell carrying a mutant gene. In some embodiments, a knock-in strategy involves substitution of an existing sequence with the provided sequence, e.g., substitution of a mutant allele with a wild-type copy. On the other hand, the term “knock-out” refers to the elimination of a gene or the expression of a gene. For example, a gene can be knocked out by either a deletion or an addition of a nucleotide sequence that leads to a disruption of the reading frame. As another example, a gene may be knocked out by replacing a part of the gene with an irrelevant (e.g., non-coding) sequence.

As used herein, the term “non-homologous end joining” or NHEJ refers to a cellular process in which cut or nicked ends of a DNA strand are directly ligated without the need for a homologous template nucleic acid. NHEJ can lead to the addition, the deletion, substitution, or a combination thereof, of one or more nucleotides at the repair site.

As used herein, the term “homology directed repair” or HDR refers to a cellular process in which cut or nicked ends of a DNA strand are repaired by polymerization from a homologous template nucleic acid. Thus, the original sequence is replaced with the sequence of the template. The homologous template nucleic acid can be provided by homologous sequences elsewhere in the genome (sister chromatids, homologous chromosomes, or repeated regions on the same or different chromosomes). Alternatively, an exogenous template nucleic acid can be introduced to obtain a specific HDR-induced change of the sequence at the target site. In this way, specific mutations can be introduced at the cut site.

The terms “vector” and “plasmid” are used interchangeably and as used herein refer to polynucleotide vehicles useful to introduce genetic material into a cell. Vectors can be linear or circular. Vectors can integrate into a target genome of a host cell or replicate independently in a host cell. Vectors can comprise, for example, an origin of replication, a multicloning site, and/or a selectable marker. An expression vector typically comprises an expression cassette. Vectors and plasmids include, but are not limited to, integrating vectors, prokaryotic plasmids, eukaryotic plasmids, plant synthetic chromosomes, episomes, viral vectors, cosmids, and artificial chromosomes.

As used herein the term “expression cassette” is a polynucleotide construct, generated recombinantly or synthetically, comprising regulatory sequences operably linked to a selected polynucleotide to facilitate expression of the selected polynucleotide in a host cell. For example, the regulatory sequences can facilitate transcription of the selected polynucleotide in a host cell, or transcription and translation of the selected polynucleotide in a host cell. An expression cassette can, for example, be integrated in the genome of a host cell or be present in an expression vector.

As used herein, the phrase “subject in need thereof” refers to a subject that exhibits and/or is diagnosed with one or more symptoms or signs of a disease or disorder as described herein.

A “chemotherapeutic agent” refers to a chemical compound useful in the treatment of cancer. Chemotherapeutic agents include “anti-hormonal agents” or “endocrine therapeutics” which act to regulate, reduce, block, or inhibit the effects of hormones that can promote the growth of cancer.

The term “composition” refers to a mixture that contains, e.g., an engineered cell or protein contemplated herein. In some embodiments, the composition may contain additional components, such as adjuvants, stabilizers, excipients, and the like. The term “composition” or “pharmaceutical composition” refers to a preparation which is in such form as to permit the biological activity of an active ingredient contained therein to be effective in treating a subject, and which contains no additional components which are unacceptably toxic to the subject in the amounts provided in the pharmaceutical composition.

As used herein, the term “effective amount” refers to the amount of a compound (e.g., a compositions described herein, cells described herein) sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications or dosages and is not intended to be limited to a particular formulation or administration route. As used herein, the term “treating” includes any effect, e.g., lessening, reducing, modulating, ameliorating or eliminating, that results in the improvement of the condition, disease, disorder, and the like, or ameliorating a symptom thereof.

The terms “modulate” and “modulation” refer to reducing or inhibiting or, alternatively, activating or increasing, a recited variable.

The terms “increase” and “activate” refer to an increase of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 50-fold, 100-fold, or greater in a recited variable.

The terms “reduce” and “inhibit” refer to a decrease of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 20-fold, 100-fold, or greater in a recited variable.

1. Safe Harbor Loci

Gene editing therapies include, for example, viral vector integration and site specific integration. Site-specific integration is a promising alternative to random integration of viral vectors, as it mitigates the risks of insertional mutagenesis or insertional oncogenesis (Kolb et al. Trends Biotechnol. 2005 23:399-406; Porteus et al. Nat Biotechnol. 2005 23:967-973; Paques et al. Curr Gen Ther. 2007 7:49-66). However, site specific integration continues to face challenges such as poor knock-in efficiency, risk of insertional oncogenesis, unstable and/or anomalous expression of adjacent genes or the transgene, low accessibility (e.g. within kB of adjacent genes), etc. These challenges can be addressed, in part, through the identification and use of safe harbor loci or safe harbor sites (SHS), which are sites in which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes.

The most widely used of the putative human safe harbor sites is the AAVS1 site on chromosome 19q, which was initially identified as a site for recurrent adenoassociated virus insertion. Other potential SHS have been identified on the basis of homology, with sites first identified in other species (e.g., the human homolog of the permissive murine Rosa26 locus) or among the growing number of human genes that appear non-essential under some circumstances. One putative SHS of this type is the CCR5 chemokine receptor gene, which, when disrupted, confers resistance to human immunodeficiency virus infection. Additional potential genomic SHS have been identified in human and other cell types on the basis of viral integration site mapping or gene-trap analyses, as was the original murine Rosa26 locus. The three top SHS, AAVS1, CCR5, and Rosa26, are in close proximity to many protein coding genes and regulatory elements. (See FIG. 2 from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety).

The AAVS1 (also known as the PPP 1R12C locus) on human chromosome 19 is a known SHS for hosting transgenes (e.g. DNA transgenes) with expected function. It is at position 19q13.42. It has an open chromatin structure and is transcription-competent. The canonical SHS locus for AAVS1 is chr19: 55,625,241-55,629,351. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference. An exemplary AAVS1 target gRNA and target sequence are provided below:

AAVS1-gRNA sequence: (SEQ ID NO: 121) ggggccactagggacaggatGTTTTAGAGCTAGAA ATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAAC TTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTT AAVS1 target sequence: (SEQ ID NO: 122) ggggccactagggacaggat

CCR5, which is located on chromosome 3 at position 3p21.31, encodes the major co-receptor for HIV-1. Disruption at this site in the CCR5 gene has been beneficial in HIV/AIDS therapy and prompted the development of zinc-finger nucleases that target its third exon. The canonical SHS locus for CCR5 is chr3: 46,414,443-46,414,942. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

The mouse Rosa26 locus is particularly useful for genetic modification as it can be targeted with high efficiency and is expressed in most cell types tested. Irion et al. 2007 (“Identification and targeting of the ROSA26 locus in human embryonic stem cells.” Nature biotechnology 25.12 (2007): 1477-1482, the relevant disclosure of which are herein incorporated by reference) identified the human homolog, human ROSA26, in chromosome 3 (position 3p25.3). The canonical SHS locus for human Rosa26 (hRosa26) is chr3: 9,415,082-9,414,043. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

Additional examples of safe harbor sites are provided in Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

The present disclosure is directed to methods for identifying safe harbor loci with benefits including, but not limited to, high knock-in efficiency and high expression of transgene. An example of applications of the presently disclosed methods is the identification of safe harbor loci for insertion of transgenes (e.g., chimeric antigen receptors (CAR)) into T-cells. In some embodiments, the safe harbor loci of the present disclosure are useful for the insertion of a sequence encoding a transgene. In some embodiments, the safe harbor sites allow for high transgene expression (sufficient to allow for transgene functionality or treatment of a disease of interest) and stable expression of the transgene over several days, weeks or months. In some embodiments, knockout of the gene at the safe harbor locus confers benefit to the function of the cell, or the gene at the safe harbor locus has no known function within the cell. In some embodiments the safe harbor locus results in stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene.

As used, a “nearby gene” can refer to a gene that is within about 100 kB, about 125 kB, about 150 kB, about 175 kB, about 200 kB, about 225 kB, about 250 kB, about 275 kB, about 300 kB, about 325 kB, about 350 kB, about 375 kB, about 400 kB, about 425 kB, about 450 kB, about 475 kB, about 500 kB, about 525 kB, about 550 kB away from the safe harbor locus (integration site).

In some embodiments, the present disclosure contemplates inserts that comprise one or more transgenes. The transgene can encode a therapeutic protein, an antibody, a peptide, a suicide gene, an apoptosis gene or any other gene of interest. The safe harbor loci identified using the method described herein allow for transgene integration that results in, for example, enhanced therapeutic properties. These enhanced therapeutic properties, as used herein, refer to an enhanced therapeutic property of a cell when compared to a typical immune cell of the same normal cell type. For example, an NK cell having “enhanced therapeutic properties” has an enhanced, improved, and/or increased treatment outcome when compared to a typical, unmodified and/or naturally occurring NK cell. The therapeutic properties of immune cells can include, but are not limited to, cell transplantation, transport, homing, viability, self-renewal, persistence, immune response control and regulation, survival, and cytotoxicity. The therapeutic properties of immune cells are also manifested by: antigen-targeted receptor expression; HLA presentation or lack thereof; tolerance to the intratumoral microenvironment; induction of bystander immune cells and immune regulation; improved target specificity with reduction; resistance to treatments such as chemotherapy.

As used herein, the term “insert size” refers to the length of the nucleotide sequence being integrated (inserted) at the safe harbor site. In some embodiments, the insert size comprises at least about 100, 200, 300, 400 or 500 basepairs. In some embodiments, the insert size comprises about 500 nucleotides or basepairs. In some embodiments, the insert size comprises up to 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp (kilo basepairs) or the sizes in between. In some embodiments, the insert size is greater than 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp or the sizes in between. In some embodiments, the insert size is within the range of 3-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-8.3 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 0.5-20 kbp or is any number in that range. In some embodiments, the insert size is 0.5-10, 0.6-10, 0.7-10, 0.8-10, 0.9-10, 1-10, 2-10, 3-10, 4-10, 5-10, 6-10, 7-10, 8-10, 9-10 kbp. In some embodiments, the insert size is 0.5-11, 0.6-11, 0.7-11, 0.8-11, 0.9-11, 1-11, 2-11, 3-11, 4-11, 5-11, 6-11, 7-11, 8-11, 9-11, or 10-11 kbp. In some embodiments, the insert size is 0.5-12, 0.6-12, 0.7-12, 0.8-12, 0.9-12, 1-12, 2-12, 3-12, 4-12, 5-12, 6-12, 7-12, 8-12, 9-12, 10-12, or 11-12 kbp. In some embodiments, the insert size is 0.5-13, 0.6-13, 0.7-13, 0.8-13, 0.9-13, 1-13, 2-13, 3-13, 4-13, 5-13, 6-13, 7-13, 8-13, 9-13, 10-13, 11-13, or 12-13 kbp. In some embodiments, the insert size is 0.5-14, 0.6-14, 0.7-14, 0.8-14, 0.9-14, 1-14, 2-14, 3-14, 4-14, 5-14, 6-14, 7-14, 8-14, 9-14, 10-14, 11-14, 12-14 or 13-14 kbp. In some embodiments, the insert size is 0.5-15, 0.6-15, 0.7-15, 0.8-15, 0.9-15, 2-15, 3-15, 4-15, 5-15, 6-15, 7-15, 8-15, 9-15, 10-15, 11-15, 12-15, 13-15, or 14-15 kbp. In some embodiments, the insert size is 0.5-16, 0.6-16, 0.7-16, 0.8-16, 0.9-16, 1-16, 2-16, 3-16, 4-16, 5-16, 6-16, 7-16, 8-16, 9-16, 10-16, 11-16, 12-16, 13-16, 14-16 or 15-16 kbp. In some embodiments, the insert size is 0.5-17, 0.6-17, 0.7-17, 0.8-17, 0.9-17, 1-17, 2-17, 3-17, 4-17, 5-17, 6-17, 7-17, 8-17, 9-17, 10-17, 11-17, 12-17, 13-17, or 14-17, 15-17 or 16-17 kbp. In some embodiments, the insert size is 0.5-18, 0.6-18, 0.7-18, 0.8-18, 0.9-18, 1-18, 2-18, 3-18, 4-18, 5-18, 6-18, 7-18, 8-18, 9-18, 10-18, 11-18, 12-18, 13-18, 14-18, 15-18, 16-18 or 17-18 kbp. In some embodiments, the insert size is 0.5-19, 0.6-19, 0.7-19, 0.8-19, 0.9-19, 1-19, 2-19, 3-19, 4-19, 5-19, 6-19, 7-19, 8-19, 9-19, 10-19, 11-19, 12-19, 13-19, 14-0.7-20, 19, 15-19, 16-19, 17-19, or 18-19 kbp. In some embodiments, the insert size is 0.5-20, 0.6-20, 0.7-20, 0.8-20, 0.9-20, 1-20, 2-20, 3-20, 4-20, 5-20, 6-20, 7-20, 8-20, 9-20, 10-20, 11-20, 12-20, 13-20, 14-20, 15-20, 16-20, 17-20, 18-20, or 19-20 kbp.

The inserts of the present disclosure refer to nucleic acid molecules or polynucleotide inserted at a safe harbor site. In some embodiments, the nucleotide sequence is a DNA molecule, e.g., genomic DNA, or comprises deoxy-ribonucleotides. In some embodiments, the insert comprises a smaller fragment of DNA, such as a plastid DNA, mitochondrial DNA, or DNA isolated in the form of a plasmid, a fosmid, a cosmid, a bacterial artificial chromosome (BAC), a yeast artificial chromosome (YAC), and/or any other sub-genome segment of DNA. In some embodiments, the insert is an RNA molecule or comprises ribonucleotides. The nucleotides in the insert are contemplated as naturally occurring nucleotides, non-naturally occurring, and modified nucleotides. Nucleotides may be modified chemically or biochemically, or may contain non-natural or derivatized nucleotide bases, as will be readily appreciated by those of skill in the art. Such modifications include, for example, labels, methylation, substitution of one or more of the naturally occurring nucleotides with an analog, internucleotide modifications. The polynucleotides can be in any topological conformation, including single-stranded, double-stranded, partially duplexed, triplexed, hairpinned, circular conformations, and other three-dimension conformations contemplated in the art.

The inserts can have coding and/or non-coding regions. The insert can comprises a non-coding sequence (e.g., control elements, e.g., a promoter sequence). In some embodiments, the insert encodes transcription factors. In some embodiments, the insert encodes an antigen binding receptors such as single receptors, T-cell receptors (TCRs), syn-notch, CARs, mAbs, etc. In some embodiments, the inserts are RNAi molecules, including, but not limited to, miRNAs, siRNA, shRNAs, etc. In some embodiments, the insert is a human sequence. In some embodiments, the insert is chimeric. In some embodiments, the insert is a multi-gene/multi-module therapeutic cassette. A multi-gene/multi-module therapeutic cassette referst to an insert or cassette having one or more than one receptor (e.g., synthetic receptors), other exogenous protein coding sequences, non-coding RNAs, transcriptional regulatory elements, and/or insulator sequences, etc.

Various cell types are contemplated as having the safe harbor sites in the present disclosure. A cell comprising a safe harbor site and/or a cell comprising an insert at a safe harbor site as described in the present disclosure can be referred to as an engineered cell. The cells can include, but are not limited to, eukaryotic cells, prokaryotic cells, animal cells, plant cells, fungal cells and the like. Optionally, the cell is a mammalian cell, for example, a human cell. In some embodiments, that engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. Non-limiting examples of immune cells that are contemplated in the present disclosure include T cell, B cell, natural killer (NK) cell, NKT/iNKT cell, macrophage, myeloid cell, and dendritic cells. Non-limiting examples of stem cells that are contemplated in the present disclosure include pluripotent stem cells (PSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), embryo-derived embryonic stem cells obtained by nuclear transfer (ntES; nuclear transfer ES), male germline stem cells (GS cells), embryonic germ cells (EG cells), hematopoietic stem/progenitor stem cells (HSPCs), somatic stem cells (adult stem cells), hemangioblasts, neural stem cells, mesenchymal stem cells and stem cells of other cells (including osteocyte, chondrocyte, myocyte, cardiac myocyte, neuron, tendon cell, adipocyte, pancreocyte, hepatocyte, nephrocyte and follicle cells and so on). In some embodiments, the engineered cells is a T cell, NK cells, iPSC, and HSPC. In some embodiments, the engineered cells used in the present disclosure are human cell lines grown in vitro (e.g. deliberately immortalized cell lines, cancer cell lines, etc.).

The methods for integrating the inserts at the safe harbor sites can be viral or non-viral delivery techniques.

In some embodiments, the nucleic acid sequence is inserted into the genome of the engineered cell by introducing a vector, for example, a viral vector, comprising the nucleic acid. Examples of viral vectors include, but are not limited to, adeno-associated viral (AAV) vectors, retroviral vectors or lentiviral vectors. In some embodiments, the lentiviral vector is an integrase-deficient lentiviral vector.

In some embodiments, the nucleic acid sequence is inserted into the genome of the T cell via non-viral delivery. In non-viral delivery methods, the nucleic acid can be naked DNA, or in a non-viral plasmid or vector. Non-viral delivery techniques can be site-specific integration techniques, as described herein or known to those of ordinary skill in the art. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.

In some embodiments, the insert is integrated at a safe harbor site by introducing into the engineered cell, (a) a targeted nuclease that cleaves a target region in the safe harbor site to create the insertion site; and (b) the nucleic acid sequence (insert), wherein the insert is incorporated at the insertion site by, e.g., HDR. Examples of non-viral delivery techniques that can be used in the methods of the present disclosure are provided in U.S. application Ser. Nos. 16/568,116 and 16/622,843, the relevant disclosures of which are herein incorporated by reference in their entirety.

2. CAR T Cell Therapy

Chimeric antigen receptor (CAR) T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to confer T cells with the ability to target a specific protein. The genetic modification of lymphocytes (e.g. T cells) by incorporation of, for example, CARs, and administration of the engineered cells to a subject is an example of “adoptive cell therapy”. As used herein, the term “adoptive cell therapy” refers to cell-based immunotherapy for transfusion of autologous or allogeneic lymphocytes, referred to as T cells or B cells. In this CAR therapy approach, cells are expanded and cultured ex vivo and genetically modified, prior to transfusion.

The expression of CARs allows the engineered T-cells to target and bind specific proteins, for example, tumor antigens. In CAR therapy, T-cells are harvested from a subject—they can be autologous T-cells from the subject own blood or from a donor that will not be receiving the CAR therapy. Once isolated, the T-cells are genetically modified with a CAR, expanded ex vivo, and administered to the subject (i.e. patient) by, e.g. infusion.

The CARs may be introduced into the T-cells using, for example, a viral technique (e.g., retroviral integration) or site-specific technique. With site specific integration of the transgenes (e.g. CARs), the transgenes may be targeted to a safe harbor locus. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.

The engineered CAR T cells have applications to immune-oncology. The CAR, for example, can be selected to target a specific tumor antigen. Examples of cancers that can be effectively targeted using CAR T cells are blood cancers. In some embodiments, CAR T cell therapy can be used to treat solid tumors.

3. Gene Editing

The terms “gene editing” or “genome editing”, as used herein, refer to a type of genetic manipulation in which DNA is inserted, replaced, or removed from the genome using artificially manipulated nucleases or “molecular scissors”. It is a useful tool for elucidating the function and effect of sequence-specific genes or proteins or altering cell behavior (e.g. for therapeutic purposes).

Currently available genome editing tools include zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs) to incorporate genes at safe harbor loci (e.g. the adeno-associated virus integration site 1 (AAVS1) safe harbor locus). The DICE (dual integrase cassette exchange) system utilizing phiC31 integrase and Bxb1 integrase is a tool for target integration. Additionally, clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) techniques can be used for targeted gene insertion.

Site specific gene editing approaches can include homology dependent mechanisms or homology independent mechanisms.

All methods known in the art for targeted insertion of gene sequences are contemplated in the methods described herein to insert constructs at safe harbor loci.

4. Crispr-Cas Gene Editing

One effective example of gene editing is the Crisp-Cas approach (e.g. Crispr-Cas9). This approach incorporates the use of a guide polynucleotide (e.g. guide ribonucleic acid or gRNA) and a cas endonuclease (e.g. Cas9 endonuclease).

As used herein, a polypeptide referred to as a “Cas endonuclease” or having “Cas endonuclease activity” refers to a CRISPR-related (Cas) polypeptide encoded by a Cas gene, wherein a Cas polypeptide is a target DNA sequence that can be cleaved when operably linked to one or more guide polynucleotides (see, e.g., U.S. Pat. No. 8,697,359). Also included in this definition are variants of Cas endonuclease that retain guide polynucleotide-dependent endonuclease activity. The Cas endonuclease used in the donor DNA insertion method detailed herein is an endonuclease that introduces double-strand breaks into DNA at the target site (e.g., within the target locus or at the safe harbor site).

As used herein, the term “guide polynucleotide” relates to a polynucleotide sequence capable of complexing with a Cas endonuclease and allowing the Cas endonuclease to recognize and cleave a DNA target site. The guide polynucleotide can be a single molecule or a double molecule. The guide polynucleotide sequence can be an RNA sequence, a DNA sequence, or a combination thereof (RNA-DNA combination sequence). A guide polynucleotide comprising only ribonucleic acid is also referred to as “guide RNA”. In some embodiments, a polynucleotide donor construct is inserted at a safe harbor locus using a guide RNA (gRNA) in combination with a cas endonuclease (e.g. Cas9 endonuclease).

The guide polynucleotide includes a first nucleotide sequence domain (also referred to as a variable targeting domain or VT domain) that is complementary to a nucleotide sequence in the target DNA, and a second nucleotide that interacts with a Cas endonuclease polypeptide. It can be a double molecule (also referred to as a double-stranded guide polynucleotide) comprising a sequence domain (referred to as a Cas endonuclease recognition domain or CER domain). The CER domain of this double molecule guide polynucleotide comprises two separate molecules that hybridize along the complementary region. The two separate molecules can be RNA sequences, DNA sequences and/or RNA-DNA combination sequences.

Genome editing using CRISPR-Cas approaches relies on the repair of site-specific DNA double-strand breaks (DSBs) induced by the RNA-guided Cas endonuclease (e.g. Cas 9 endonuclease). Homology-directed repair (HDR) of these DSBs enables precise editing of the genome by introducing defined genomic changes, including base substitutions, sequence insertions, and deletions. Conventional HDR-based CRISPR/Cas9 genome-editing involves transfecting cells with Cas9, gRNA and donor DNA containing homologous arms matching the genomic locus of interest.

HITI (homology independent targeted insertion) uses a non-homologous end joining (NHEJ)-based homology-independent strategy and the method can be more efficient than HDR. Guide RNAs (gRNAs) target the insertion site. For HITI, donor plasmids lack homology arms and DSB repair does not occur through the HDR pathway. The donor polynucleotide construct can be engineered to include Cas9 cleavage site(s) flanking the gene or sequence to be inserted. This results in Cas9 cleavage at both the donor plasmid and the genomic target sequence. Both target and donor have blunt ends and the linearized donor DNA plasmid is used by the NHEJ pathway resulting integration into the genomic DSB site. (See, for example, Suzuki, K., et al. (2016). In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature, 540(7631), 144-149, the relevant disclosures of which are herein incorporated in their entirety).

Methods for conducing gene editing using CRISPR-Cas approaches are known to those of ordinary skill in the art. (See, for example, U.S. application Ser. No. 16/312,676, U.S. Ser. No. 15/303,722, and U.S. Ser. No. 15/628,533, the disclosures of which are herein incorporated by reference in their entirety). Additionally, uses of endonucleases for inserting transgenes into safe harbor loci are described, for example, in U.S. application Ser. No. 13/036,343, the disclosures of which are herein incorporated by reference in their entirety.

The guide RNAs and/or mRNA (or DNA) encoding an endonuclease can be chemically linked to one or more moieties or conjugates that enhance the activity, cellular distribution, or cellular uptake of the oligonucleotide. Non-limiting examples of such moieties include lipid moieties such as a cholesterol moiety, cholic acid, a thioether, a thiocholesterol, an aliphatic chain (e.g., dodecandiol or undecyl residues), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, adamantane acetic acid, a palmityl moiety and an octadecylamine or hexylamino-carbonyl-t oxycholesterol moiety. See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.

5. Therapeutic Applications

For therapeutic applications, the engineered cells, populations thereof, or compositions thereof are administered to a subject, generally a mammal, generally a human, in an effective amount.

The engineered cells may be administered to a subject by infusion (e.g., continuous infusion over a period of time) or other modes of administration known to those of ordinary skill in the art.

The engineered cells provided herein can be administered as part of a pharmaceutical compositions. In some embodiments, the present disclosure provides compositions comprising a guide RNA of the present disclosure. The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.

The engineered cells provided herein not only find use in gene therapy but also in non-pharmaceutical uses such as, e.g., production of animal models and production of recombinant cell lines expressing a protein of interest.

The engineered cells of the present disclosure can be any cell, generally a mammalian cell, generally a human cell that has been modified by integrating a transgene at a safe harbor locus described herein. In some embodiments, the engineered cells are immune cells. In some embodiments, the engineered cells are lymphocytes. In some embodiments, the engineered cells are T cells or T cell precursors.

The engineered cells, compositions and methods of the present disclosure are useful for therapeutic applications such as CAR T cell therapy and TCR T cell therapy. In some embodiments, the insertion of a sequence encoding a transgene within a safe harbor locus maintains the TCR expression relative to instances when there is no insertion and enables transgene expression while maintaining TCR function.

Various diseases treated using the engineered cells, populations thereof, or compositions thereof are provided herein. Non-limiting examples of such diseases include alopecia areata, autoimmune hemolytic anemia, autoimmune hepatitis, cancer, dermatomyositis, diabetes (type 1), certain juvenile idiopathic arthritis, glomerulonephritis, Graves' disease, Guillain Valley Syndrome, idiopathic thrombocytopenic purpura, myasthenia gravis, certain myocarditis, multiple sclerosis, pemphigus/pemphigoid, pernicious anemia, polyarteritis nodosa, polymyositis, primary bile With cirrhosis, psoriasis, rheumatoid arthritis, scleroderma/systemic sclerosis, Sjogren's syndrome, systemic lupus erythematosus, certain thyroiditis, certain uveitis, vitiligo, multiple vasculitis (Wegener)); autoimmune disorders including, but not limited to, granulomatosis; hematopoietic tumors including but not limited to acute and chronic leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome; tumors of the prostate, breast, lung, colon, uterus, skin, liver, bone, pancreas, ovary, testis, bladder, kidney, head, neck, stomach, cervix, rectum, larynx, or esophagus solid tumors; HIV (human immunodeficiency virus) related disorders, RSV (respiratory syncytial virus) related disorders; EBV (Epstein-Barr virus) related disorders; CMV (cytomegalovirus) related disorders; and infectious diseases including, but not limited to, adenovirus-related disorders and BK polyomavirus-related disorders.

Cancers that can be treated with the engineered cells (e.g., CAR T-cells) of the present disclosure, populations thereof, or compositions thereof include blood cancers. In some embodiments, the cancer treated using the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof is a hematologic malignancy or leukemia. In some embodiments, the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof are used for the treatment of acute lymphoblastic leukemia (ALL) or diffuse large B-cell lymphoma (DLBCL). In some embodiments, the cancer is acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplasia, myelodysplastic syndromes, acute T-lymphoblastic leukemia, or acute promyelocytic leukemia, chronic myelomonocytic leukemia, or myeloid blast crisis of chronic myeloid leukemia. Examples of cancers treatable using the engineered cells (e.g., CAR T-cells) described herein include, without limitation, breast cancer, ovarian cancer, esophageal cancer, bladder or gastric cancer, salivary duct carcinoma, salivary duct carcinomas, adenocarcinoma of the lung or aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. In some other embodiments, the cancer is brain cancer, breast cancer, cervical cancer, colon cancer, colorectal cancer, endometrial cancer, esophageal cancer, leukemia, lung cancer, liver cancer, melanoma, ovarian cancer, pancreatic cancer, rectal cancer, renal cancer, stomach cancer, testicular cancer, or uterine cancer. In yet other embodiments, the cancer is a squamous cell carcinoma, adenocarcinoma, small cell carcinoma, melanoma, neuroblastoma, sarcoma (e.g., an angiosarcoma or chondrosarcoma), larynx cancer, parotid cancer, biliary tract cancer, thyroid cancer, acral lentiginous melanoma, actinic keratoses, acute lymphocytic leukemia, acute myeloid leukemia, adenoid cystic carcinoma, adenomas, adenosarcoma, adenosquamous carcinoma, anal canal cancer, anal cancer, anorectum cancer, astrocytic tumor, bartholin gland carcinoma, basal cell carcinoma, biliary cancer, bone cancer, bone marrow cancer, bronchial cancer, bronchial gland carcinoma, carcinoid, cholangiocarcinoma, chondrosarcoma, choroid plexus papilloma/carcinoma, chronic lymphocytic leukemia, chronic myeloid leukemia, clear cell carcinoma, connective tissue cancer, cystadenoma, digestive system cancer, duodenum cancer, endocrine system cancer, endodermal sinus tumor, endometrial hyperplasia, endometrial stromal sarcoma, endometrioid adenocarcinoma, endothelial cell cancer, ependymal cancer, epithelial cell cancer, Ewing's sarcoma, eye and orbit cancer, female genital cancer, focal nodular hyperplasia, gallbladder cancer, gastric antrum cancer, gastric fundus cancer, gastrinoma, glioblastoma, glucagonoma, heart cancer, hemangioblastomas, hemangioendothelioma, hemangiomas, hepatic adenoma, hepatic adenomatosis, hepatobiliary cancer, hepatocellular carcinoma, Hodgkin's disease, ileum cancer, insulinoma, intraepithelial neoplasia, interepithelial squamous cell neoplasia, intrahepatic bile duct cancer, invasive squamous cell carcinoma, jejunum cancer, joint cancer, Kaposi's sarcoma, pelvic cancer, large cell carcinoma, large intestine cancer, leiomyosarcoma, lentigo maligna melanomas, lymphoma, male genital cancer, malignant melanoma, malignant mesothelial tumors, medulloblastoma, medulloepithelioma, meningeal cancer, mesothelial cancer, metastatic carcinoma, mouth cancer, mucoepidermoid carcinoma, multiple myeloma, muscle cancer, nasal tract cancer, nervous system cancer, neuroepithelial adenocarcinoma nodular melanoma, non-epithelial skin cancer, non-Hodgkin's lymphoma, oat cell carcinoma, oligodendroglial cancer, oral cavity cancer, osteosarcoma, papillary serous adenocarcinoma, penile cancer, pharynx cancer, pituitary tumors, plasmacytoma, pseudosarcoma, pulmonary blastoma, rectal cancer, renal cell carcinoma, respiratory system cancer, retinoblastoma, rhabdomyosarcoma, sarcoma, serous carcinoma, sinus cancer, skin cancer, small cell carcinoma, small intestine cancer, smooth muscle cancer, soft tissue cancer, somatostatin-secreting tumor, spine cancer, squamous cell carcinoma, striated muscle cancer, submesothelial cancer, superficial spreading melanoma, T cell leukemia, tongue cancer, undifferentiated carcinoma, ureter cancer, urethra cancer, urinary bladder cancer, urinary system cancer, uterine cervix cancer, uterine corpus cancer, uveal melanoma, vaginal cancer, verrucous carcinoma, VIPoma, vulva cancer, well-differentiated carcinoma, or Wilms tumor.

In some embodiments, the present disclosure provides methods of treating a subject in need of treatment by administering to the subject a composition comprising any of the engineered cells described herein. As used, the terms “treat,” “treatment,” and the like refer generally to obtaining a desired pharmacological and/or physiological effect. That effect is preventive in terms of complete or partial prevention of the disease and/or therapeutic in terms of partial or complete cure of the disease and/or adverse effects resulting from the disease. The term “treatment”, as used herein, encompasses any treatment of a disease in a subject (e.g., mammal, e.g., human). Treatment may also refer to the administration of the engineered cells provided herein to a subject that is susceptible to the disease but has not yet been diagnosed as suffering from it, including preventing the disease from occurring; inhibiting disease progression; or reducing the disease (i.e., causing a regression of the disease). Further, treatment may stabilize or reduce undesirable clinical symptoms in subjects (e.g., patients). The cells provided herein populations thereof, or compositions thereof may be administered before, during or after the occurrence of the disease or injury.

In certain embodiments, the subject has a disease, condition, and/or injury that can be treated and/or ameliorated by cell therapy. In some embodiments, the subject in need of cell therapy is a subject having an injury, disease, or condition, thereby causing cell therapy (e.g., therapy in which cellular material is administered to the subject). However, it is contemplated that it is possible to treat, ameliorate and/or reduce the severity of at least one symptom associated with the injury, disease or condition. In certain embodiments, a subject in need of cell therapy includes, but is not limited to, a bone marrow transplant or stem cell transplant candidate, a subject who has received chemotherapy or radiation therapy, a hyperproliferative disease or cancer (e.g., a hematopoietic system), a subject having or at risk of developing a hyperproliferative disease or cancer), a subject having or at risk of developing a tumor (e.g., solid tumor), viral infection or virus. It is also intended to encompass subjects suffering from or at risk of suffering from a disease associated with an infection.

In some embodiments, the present disclosure provides a composition of the present disclosure along with instructions for use. The instructions for use can be present in the kits as a package insert, in the labeling of the container of the kit or components thereof, or can be in digital form (e.g. on a CD-ROM, via a link on the internet). A kit can include one or more of a genome-targeting nucleic acid, a polynucleotide encoding a genome-targeting nucleic acid, a site-directed polypeptide, and/or a polynucleotide encoding a site-directed polypeptide. Additional components within the kits are also contemplated, for example, buffer (such as reconstituting buffer, stabilizing buffer, diluting buffer), and/or one or more control vectors.

6. Combination Therapies

In some embodiments, an engineered cells of the present disclosure or composition thereof is administered with at least one additional therapeutic agent. Any suitable additional therapeutic agent may be administered with an engineered cell provided herein, populations thereof, or compositions thereof. In some aspects, the additional therapeutic agent is selected from radiation, an ophthalmologic agent, a cytotoxic agent, a chemotherapeutic agent, a cytostatic agent, an anti-hormonal agent, an immunostimulatory agent, an anti-angiogenic agent, and combinations thereof.

In some embodiments, an engineered cell of the present disclosure or composition thereof is administered with a steroid. The administration of a steroid can prevent or mitigate the risk of a subject receiving the engineered cell(s) or composition thereof having an autoimmune reaction.

The additional therapeutic agent may be administered by any suitable means. In some embodiments, the engineered cells described herein, populations thereof, or compositions thereof and the additional therapeutic agent is administered in the same pharmaceutical composition, e.g. by infusion. In some embodiments, the engineered cells described herein and additional therapeutic agent are included in different pharmaceutical compositions.

The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.

Various modes of administering the additional therapeutic agents are contemplated herein. In some embodiments, the additional therapeutic agent is administered by any suitable mode of administration. Generally, modes of administration include, without limitation, intravitreal, subretinal, suprachoroidal, intraarterial, intradermal, intramuscular, intraperitoneal, intravenous, nasal, parenteral, topical, pulmonary, and subcutaneous routes.

In embodiments where the engineered cells provided herein and the additional therapeutic agent are included in different pharmaceutical compositions, administration of the engineered cells provided herein can occur prior to, simultaneously, and/or following, administration of the additional therapeutic agent.

EXAMPLES

The following are examples of methods and compositions of the invention. It is understood that various other embodiments may be practiced, given the general description provided herein.

Below are examples of specific embodiments for carrying out the present invention. The examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperatures, etc.), but some experimental error and deviation should, of course, be allowed for.

The practice of the present invention will employ, unless otherwise indicated, conventional methods of protein chemistry, biochemistry, recombinant DNA techniques and pharmacology, within the skill of the art. Such techniques are explained fully in the literature. See, e.g., T. E. Creighton, Proteins: Structures and Molecular Properties (W.H. Freeman and Company, 1993); A. L. Lehninger, Biochemistry (Worth Publishers, Inc., current addition); Sambrook, et al., Molecular Cloning: A Laboratory Manual (2nd Edition, 1989); Methods In Enzymology (S. Colowick and N. Kaplan eds., Academic Press, Inc.); Remington's Pharmaceutical Sciences, 18th Edition (Easton, Pennsylvania: Mack Publishing Company, 1990).

Example 1: Identification of Knock-In Loci in Coding Regions

The objective of the experiments in this set of examples was to identify T-cell knock-in (KI) loci in coding regions outside of the T Cell Receptor Alpha Constant (TRAC) locus. To select candidate loci, the criteria and requirements shown in Table 1 were used.

TABLE 1 Criteria used for identification of candidate knock-in loci within coding regions Detailed Datasets Considered for Criteria Requirements identification of loci KI High expression at Knock in efficiency efficiency d2 (day 2) data on ~90 genes Similar expression derived from dynamics as TRAC Roth, T. L., et al. 2019. (stable expression (Rapid discovery of synthetic upon activation) DNA sequences to rewrite endogenous Accessible T cell circuits. bioRxiv, 604561.) chromatin Bulk RNA-seq data at do, d2, d3 and d4: gRNA editing (i) publicly available data; efficiency (ii) data derived from Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561.); and (iii) internally generated data Bulk ATAC-seq data at do, d2, d3 and d4: (i) data derived from Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561.); and (ii) internally generated data Safety Does not affect T cell screening data proliferation, Achilles' project on cancer cell lines data cytolytic activity or Annotated oncogenes and tumor signaling of T cells suppressors from TCGA Annotated functions in immune cells Be careful with tumor suppressors and oncogenes

Generally, the requirements for candidate KI loci within the coding regions was that the coding gene is not essential for T cell function or the knock-out of that gene would be beneficial to chimeric antigen receptor therapy (CAR T) functions.

As shown in Table 1, some of the data utilized, for comparison purposes, to identify candidate KI loci was sourced, in part, from Roth, T. L., et al. 2019 (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), the relevant disclosures of which are herein incorporated by reference in their entirety. A summary of data in the Roth, T. L. et al. paper is shown in FIG. 3 .

FIG. 4A and FIG. 4B show the processed RNA-seq data, showing that samples cluster based on activation status and by cell type. Donor 4 (AKI4) was identified as an outlier, as it clustered differently than the others, and was removed from remaining analysis. The transcript expression data from RNA-seq experiments on the 90 genes cited in the Roth, T. L. et al. paper was correlated to transcript expression data in Roth, T. L. et al. paper. (See FIG. 5A and FIG. 5B).

FIG. 6 shows the process ATAC-seq data, which focused on the 10 kb area around the transcription start site (TSS). Again, donor 4 (AK14) was identified as an outlier, based on expression profile in both CD4 and CD8 cells, and was removed from remaining analysis. The results of the remaining ATAC-seq analysis are shown in FIGS. 7A-8 . The data in FIG. 7A for TSS enrichment scores also indicated that all libraries were high quality. The data on open chromatin regions around the TRAC locus revealed the highest signal near exon 3 rather than exon 1 (FIG. 8 ).

Determination of Knock-In Efficiency:

The K1 efficiency results (obtained using the model described infra) based on the 5 donors, 2 gRNA, and 2 replicates/gRNAs from the Roth, T. L. et al. paper are shown in FIG. 9 and FIG. 10 .

A linear model was built to estimate KI efficiency of approximately 90 genes using RNA-seq and ATAC-seq data. The linear model captured 33% of the variation in the data (i.e. R²=0.33). FIG. 11 shows KI efficiency versus day 2 (d2) RNA-seq data, day 4 (d4) RNA seq data, and d2 ATAC data. The linear model was applied to remaining candidate genes to estimate their KI efficiency.

The candidate coding loci were selected by first ranking all genes in the pooled data sets by predicted KI efficiency, using RNA-seq expression data from d2 (day 2). Candidate coding loci were required to be stably expressed during T cell activation (e.g., <=2-fold expression change relative to day 0 (d0). The candidate loci also had to be accessible based on ATAC-seq data. Using that selection process/requirements, 16 well-characterized coding genes (with known functions) were selected as candidate genes. The knockout of these 16 would confer a benefit to the function of CART cells (e.g. B2M, CD5, SMAD2, PTPRC, CD3E). An additional 12 coding genes with high predicted KI efficiency and no apparent essential function (inert coding genes) were selected as candidate genes. (See Table 2).

TABLE 2 KI Candidate Loci selected Genes with Known Functions Inert Coding Genes B2M (~70%) CD2 SUB1 CD3E (~50%) SMAD2 EDF1 PTPRC (~50%) SLC38A1 CAPNS1 CD3G (~30%) TIGIT SRP14

SOCS1 PTPN2 RTRAF APRT Tested in Roth, T.L. et al CBLB PTPRCAP paper (reported editing PTEN SRSF9 efficiency from Roth, PTPN6 FTL T.L. et al paper) CD5 TRIM28 TET2 SERF2 TRAC RPS23

Example 2: Identification of Knock-In Loci in Gene Deserts

The criteria for selection of candidate loci in non-coding regions or gene deserts is summarized in Table 3.

TABLE 3 Criteria used for identification of candidate knock-in loci within non-coding regions Datasets Considered for Criteria Detailed Requirements identification of loci KI Accessible chromatin Bulk ATAC-seq data efficiency at d0, d2, d3 and d4: (i) data derived from Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561.); and (ii) internally generated data Safety >10 kb from cancer-related Ensembl genes genes or TADS Annotated oncogenes and tumor >10 kb from any suppressors from TCGA miRNA/functional small Annotated enhancers RNAs from Encode and papers >10 kb from any 5' gene end >10 kb from any regulatory regions (ultra-conserved elements, enhancers)

To select candidate regions within the non-coding regions, the inventors here started by looking in highly accessible regions of the genome (10 kb windows). The most accessible region overlapped with (i) annotated protein coding genes (>50% accessible regions), (ii) pseudogenes and noncoding RNAs (˜20% accessible regions), and (iii) enhancer/regulatory regions (˜20% accessible regions). The candidate genes were required to be <10 kb from the coding regions. A few regions that overlapped with long intergenic noncoding RNAs (lincRNAs) but did not have apparent function in T cells were also considered.

Examples of other criteria that have been used in the art for selection of SHS are described, for example in Pellenz, S., et al. (2019). New human chromosomal sites with “safe harbor” potential for targeted transgene insertion. Human gene therapy, 30(7), 814-828, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIG. 12 is a plot showing the normalized ATAQ SEQ data for a top candidate non-coding region.

Using the above-described selection process/requirement, 11 candidate regions in gene deserts were selected. In total, there were 39 KI candidate loci, including those in coding and non-coding regions that would be evaluated as safe harbor loci (predicted loci).

Example 3: Experimental Evaluation of Predicted Loci

Materials

-   -   120 sgRNAs were ordered from Synthego, 3 sgRNAs per region, and         editing efficiency was assessed by next generation sequencings         (NGS).         -   87 targeted coding genes         -   33 targeted gene deserts     -   189 constructs were synthesized by Genscript         -   Homology arm: 450 bp each         -   eGFP was used as the reporter         -   Vector backbone: pUC57-Kan backbone         -   78 with endogenous promoters         -   111 with EF1a-HTLV promoter     -   Constructs were sequence verified by Genscript and majority were         internally verified by sequencing. The sgRNA sequences are         provided in Table 4 and the construct sequences are provided in         Table 5.

Methods

To evaluate the effectiveness of the predicted loci, the following were used:

-   -   (87 endogenous constructs+120 exogenous construct)*2=414         wells+Controls=460     -   3 donors, 2 replicates at 3 time points: wk 1 (d6=day 6), wk 3         (d21=day 21) and wk 4 (d28=day 28)     -   Controls     -   DNA-only (no ribonucleoprotein (RNP)): episomal expression (n=8)     -   DNA+non-targeting guides+RNP: to check if DNA delivery is more         efficient with RNP (n=8)

pMax GFP was measured to check if transfection is ok (n=3).

WT cells with no electroporation

WT cells with electroporation

Controls were spread out across plates.

Cells were electroporated without RNP/HDR to check if cell counting makes sense.

2 more donors were added and changed to 3 replicates at 1 time point: wk 1 (d6)

FACS panel: GFP, TCR, Zombie

Washed every 3 wells.

The secondary data collected included: RNA-seq data: at d0, d2, and d4 (to determine stable expression) and ATAC-seq data: at d2 (to identify activated cells). The methods used for conducting the RNA-seq and ATAC-seq experiments are in Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), which is herein incorporated by reference in its entirety.

Automated gating was performed on FACS data, using .fcs files. For constructs with endogenous promoters, all 5 donors and all 3 time points were used. For constructs with EF1a promoter, used 3 donors (donors 1-3) and 2 time points (wk 3 and wk 4).

To summarize data, wells with a % K1 efficiency (% GFP_high cells)<=10% (likely a gating error, experimental error or minimal integration) were removed. Loci were then ranked by median expression among donors and median % K1 efficiency among donors.

Loci significance was calculated using robust rank aggregation, which was the methodology used for consistent ranking of loci among donors and time points. Methods for conducting robust rank aggregation are known in the art. (See, for example, Kolde, R., et al. (2012). Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics (Oxford, England), 28(4), 573-580, the disclosure of which is herein incorporated by reference in its entirety).

Results

The results from the analysis of controls and experimental groups is shown in FIGS. 13A-25 .

The results of the pmax_GFP control experiments revealed that donor 5 had significantly higher cell count than other donors. Generally, the GFP_high readings decreased over time, as expected. (FIGS. 13A and 13B).

Experiments to analyze non-targeting controls for changes in episomal GFP expression, revealed that episomal GFP expression decreased to less than 0.05 over time. (FIGS. 14A and 14B) Some of the outliers were attributed to gating errors, which were most severe in donor 3. WT control experiments also exhibited <0.05 GFP_high readings, as expected (FIG. 15 ).

As shown in FIG. 16 and FIG. 17 , there was a more consistent trend among donors when using sgRNAS to target the B2M safe harbor locus.

A comparison of GFP expression trends between sgRNA79 and sgRNA83 for TRAC insertion and expression with an endogenous reporter revealed that donor 2 trends were different between sgRNA79 and sgRNA83, while donor 4 trends were the same (FIG. 18 and FIG. 22 ). Some potential reasons for the observed variation between replicates and donors include:

-   -   (1) manual handling of a large number of plates (e.g., FIG. 26         ):         -   Edge effects         -   Electroporation errors     -   (2) Inherent differences among donors (e.g., FIG. 27 ):         -   There were consistent differences with certain wells             throughput the assay (spanning multiple weeks)         -   There were variable cell numbers between donors     -   (3) Gating errors (e.g. FIG. 28 ):         -   1 peak vs >2 peaks in GFP signals

Example 4: Ranking Loci by Expression and KI Efficiency

The loci were ranked based on mean florescence intensity (MFI) of reporter gene, GFP, and KI efficiency.

FIG. 29 shows GFP MFI and KI efficiency for all significant loci having endogenous promoters. The B2M locus reported the highest GFP MFI. The TRAC locus was among the top 10 MFI. The highest GFP MFI readings were reported in week 1 and reduced slightly in weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed greater variation among donors than GFP MFI.

FIG. 30 shows GFP MFI and KI efficiency for all significant loci having exogenous promoters (e.g. EF1a promoters). The TRAC locus reported the highest GFP MFI. There was comparable expression between weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed less variation when driven by the exogenous promoters than when driven by endogenous promoters.

FIGS. 31A, 31B, and 31C show GFP MFI and KI efficiency for all significant loci having endogenous and exogenous (e.g., EF1a) promoters. The results showed that expression driven by EF1a promoters is about 10× higher than endogenous promoters (FIG. 31A). With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. At weeks 3 and 4, KI efficiency was higher when driven by the exogenous promoters than when driven by endogenous promoters.

Example 5: Evaluation of TCR Expression in Candidate Noncoding Sites

This experiment was conducted to identify target loci and integration sites that enable high transgene expression without disrupting the TCR. Some gene deserts (e.g. gene deserts 2, 3, 5, and 6) were identified as having high transgene expression (FIG. 32A).

To evaluate and identify preferred knock-in sites, TCR expression was measured following circuit cassette knock in of PrimeR (Prime Receptor (Myc)). Myc denotes an N-terminal Myc epitope tag to facilate detection of surface expressed primer receptor. Briefly, CD3-CD28 Dynabead-activated T cells were electroporated with sgRNA/Cas9 RNPs targeting the indicated sites (see FIGS. 32B and 33A), as well as HDRTs with homology arms directing HDR-mediated integration into the indicated sites. At day 6 post-electroporation, cells were stained with anti-TCRalpha/beta and anti-myc antibodies and analyzed on an Attune NxT flow cytometer. As shown in FIG. 32B, the TCR expression was maintained at GS94 and GS102 candidate integration (knock-in) sites. Only ⅔ of the cells that had circuit cassette knock in of PrimeR at GS79 (TRAC) locus maintained TCR expression. These results indicated that the GS94 and GS102 sites showed better potential for TCR stimulation.

The percentage of cells showing effective knock-in (based on measurements of PrimeR) was 36%±4% when using the GS94 integration site, as compared to 32%±5% when using the TRAC integration site. These results revealed integration sites, including GS94, that supported reproducibly high circuit cassette knockin rates. See FIG. 33A.

Example 6: Evaluation of GS94 Circuit Expression and Function

GS94 is a candidate integration site located on chromosome 11's distal q arm. It is within 180-350 kb of the promoters for ETS1 and FLI1 (FIG. 33B), however that is considered low-risk for integration vector gene therapy. The circuit expression and function potential of the GS94 gene was evaluated.

T cells underwent circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site. The cells were cocultured with K562 C19 cells for 48 hours and then the PrimeR induced CAR MFI was compared to the PrimeR MFI.

Briefly, T cells generated as described in the Example above were cocultured with K562 CD19+/MSLN− cells at day 7 post-electroporation. MSLN (mesothelin) is a gene that is overexpressed in human pancreatic cancer. Cells were then stained with anti-FLAG antibody 48 h post initiation of coculture and analyzed on an Attune NxT flow cytometer. The results revealed that GS94 yields superior CAR induction with high prime R expression following the 48-hour coculture with the K562 C19 cells. See FIG. 34A. GS94 resulted in prime antigen-dependent CAR expression that was approximately two-fold higher than the expression in several other candidate integration sites as well as the TRAC integration site. Additionally, on average, the prime receptor surface expression level was no less than 50% of expression level when using the TRAC integration site.

Cytotoxicity and Cytokine Secretion

To evaluate the effect of the candidate integration site on cytotoxicity and cytokine secretion, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 C19/MSLN cells for 48 hours. MSLN is a gene that is overexpressed in human pancreatic cancer. The cells were treated at a 1:1 effector:target cell ratio (1:1 E:T)). Briefly, T cells generated as described above were cocultured with K562 CD19+/MSLN+ cells at day 7 post-electroporation. 48 h post initiation of coculture, supernatants were collected and analyzed via Luminex® for cytokine levels. The cytokines measure were IL-2, INFg, and TNF. Cytotoxicity was analyzed by measuring luciferase activity of remaining target cells after 48 h. Each of the data points in FIG. 34B represent two replicates and the lines represent the range of cytotoxicity for the replicates. As shown in FIG. 34B, the GS94 integration sites resulted in superior cycotoxic ability and cytokine secretion following the 48-hour coculture with K562 C19/MSLN cells.

Prime-Independent Cytotoxicity

To compare the effect of the candidate integration site on cytotoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 CD19+/MSLN+ cells or K562 CD19−/MSLN+ cells (“K562 MSLN”) at day 7 post-electroporation for 48 hours. 0.3, 1.0, and 3.0 E:T cell ratios were tested. See FIG. 35A and FIG. 35B. At 48 h post initiation of coculture, cytotoxicity was analyzed by measuring luciferase activity of remaining target cells As shown in FIG. 35B, the GS94 integration site resulted in equivalent cytotoxic potential to the TRAC integration site and there was no prime-independent cytotoxicity.

Prime-Independent Cytokine Section

To compare the effect of the candidate integration site on cytoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site, generated as described above, were cocultured with K562 CD19+/MSLN+ cells. A group that had target cells only (E:T=0; Targets only) was compared to a group with an E:T cell ratio of 1. Following the 48 h coculture with the K562 CD19+/MSLN+ cells, supernatant was collected and analyzed via Luminex® for cytokine levels to measure secretion of IL-2, INFg and TNF cytokines. See FIG. 36A and FIG. 36B. As shown in FIG. 36B, the GS94 integration site resulted in equivalent cytokine secretion to the TRAC integration site and there was no prime-independent secretion of IL-2, INFg or TNF.

Prime-Independent CAR Expression

To evaluate the effect of the candidate integration site on prime-independent CAR expression, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site, GS94 integration site, and GS102 integration site were cultured in vitro for 32 days. The cells were treated with repetitive CD3/CD28 stimulation at days 5, 12, 19 and 28 of the experiment. On Day 16, the cells were evaluated for CAR expression using a flow cytometry assay. As shown in FIG. 37 , T cell activation through TCR did not result in prime R-independent CAR expression from circuit cassette integration at the candidate integration sites.

T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads. Cells were analyzed for PrimeR expression by myc epitope tag staining, and for CAR expression by FLAG epitope tag staining at the indicated time points. Flow analysis was performed on an Attune NxT flow cytometer.

Example 7: Evaluating Stability of Prime Receptor Expression Over Several Weeks

To evaluate the effect of the candidate integration sites on stable (sustained) expression of PrimeR, T cells that had undergone circuit cassette integration with PrimeR at the integration sites indicated in FIG. 38 were cultured in vitro for 32 days. Briefly, T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads repetitive stimulation. Flow cytometry assays were run on days 16 and 32 using an Attune NxT flow cytometer. The cells were analyzed for PrimeR expression by myc epitope tag staining. As shown in FIGS. 38A and 38B, the GS94 integration site resulted in stable PrimeR expression over at least a 4-week period.

Example 8: Evaluation of On-Target Editing Efficiency

To evaluate the on-target editing efficiency of candidate knock-in sites, iGUIDE-Seq assay was used. The methods used for conducting the iGUIDE-Seq assay are illustrated in FIG. 39A and provided in Nobles et al., Genome Biology (2019), which is hereby incorporated by reference in its entirety. As shown in FIG. 39B, the GS94 integration site had the highest on-target editing efficiency of the evaluated candidate integration sites. As shown in FIG. 39C, GS94 resulted in no putative off-target editing as observed with two donors.

Example 9: Evaluation of GS94 Knock-In Methods

Elevation prediction: Computational predictions of potential off-target sites from (gs94) were performed using Elevation-search (algorithm described in Listgarten et al. 2018. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs. Nat Biomed Engr 2, 37-48; software obtained from github.com/Microsoft/Elevation). All sites identified by Elevation-search were subjected to analysis using rhAmp-seg™.

rhAmpSeg™: 49 candidate off-target sites for GS94 identified by iGUIDE or the Elevation prediction algorithm and the GS94 target site were characterized by rhAmpSeg™ (Integrated DNA Technologies, Inc.). This targeted amplification enables NGS-based quantification of the editing occurring at numerous sites simultaneously. Genomic DNA from T cells from at least 2 donors that had been treated singly with each of the following 7 guides: GS84, GS94, GS95, GS96, GS102, GS108, and GS138 was isolated with the GenFind® V3 DNA purification system (Beckman Coulter). Two separate rhAmpSeg™ amplification pools were used to cover the 50 loci, the procedure was performed as recommended by Integrated DNA Technologies for each of the samples. The rhAmpSeg™ libraries were sequenced on a MiniSeg™ with a Mid Output Kit (300-cycles) (Illumina). The CRISPResso2 algorithm (github.com/pinellolab/CRISPResso2) was used to determine the percentage of insertions and deletions at each of the amplified loci. Statistical significance (FDR-adjusted p-value≤0.001) using a chi-squared test was only observed at the GS94 site.

RNA-seq: To evaluate changes induced by GS94 integration at the transcriptional level, a CD19/MSLN circuit was integrated at the GS79 (TRAC), GS94, and GS102 integration sites. On day 6 post-integration, 1e6 edited cells were sorted using a BD FACSAria based on transgene expression. RNA was isolated from sorted T cells with the RNeasy kit (Qiagen). Purified RNA was converted into an NGS library using the TruSeq™ RNA Library Prep Kit v2 (Illumina). Libraries were sequenced on either the NovaSeq™ 6000 or NextSeq™ 550 instruments (Illumina). The STAR 2.7.3a aligner (Dobin A. et al. Bioinformatics. 2013. 29:15-21) was used to align the RNA-seq data against the reference human GRCh38 transcriptome and to obtain gene-level read counts. edgeR (Robinson M D et al. Bioinformatics. 2010. 26: 139-140) was used to compute differential expression, combining data across both donors. The only genes within 300 Kb of the GS94 site, ETS1 and FLI1, were not differentially expressed in cells with integration at the GS94 integration site compared to cells with integration at any of the other two loci. At an FDR-adjusted p-value cutoff of 0.01, the number of differentially expressed genes was minimal (<100 genes genome-wide).

Cytokine-independent growth assay: To evaluate the safety of the primary T cells with GS94 locus KI, cytokine-independent growth assay was performed to evaluate the potential for oncogenic transformation. Briefly, primary human T cells that had undergone CD19/MSLN circuit cassette integration at GS94 locus were thawed and recovered overnight. 1×10⁶ cells were then seeded in one well of a 24 well-GRex plate, culturing for 5 days in the medium with or without cytokines. Cell number and viability were recorded at days 0, 3 and 5. As a positive control, 1×10⁶ Jurkat cells were cultured in the medium without cytokines in parallel. As shown in FIG. 43 , while GS94 KI T cells maintained good viability and total cell count when cultured with cytokine, the viability of GS94 KI T cells drastically decreased over the course of 5 days when cultured without cytokine and there was no viable cell left on day 5. The positive control Jurkat cells maintained good viability and expansion without cytokine throughout the assay. Taken together, this data shows that GS94 edited primary human T cells still depend on exogenous cytokine for growth, survival and expansion, therefore, there is no concern for cellular transformation.

Results

The specificity of CRISPR reagents (e.g. SpCas9 complexed with sgRNA) targeting candidate loci including GS94 was evaluated by iGUIDE-seq (FIG. 40 ). GS94-targeting CRISPR RNP showed the highest percentage of iGUIDE-seq oligo cassette trapping events of all candidates evaluated, and the control sgRNA sequences from the iGUIDE-seq paper showed similar specificities to what was reported in the original publication, suggesting that the assay performed as expected.

Putative off-target sites were taken from the iGUIDE-seq output, which already suggested that the putative sites were spurious. Additional target sites were predicted by a computational approach (Elevation software package). rhAmp-seg™ was used to prepare high-throughput sequencing libraries for each of the putative off-target sites, and the method was applied to DNA samples from T cells electroporated with CRISPR RNPs targeting the candidate target sites. The resulting NGS data were processed with CRISPResso2 software, and the frequency of insertions and deletions (indels) was taken as indication of CRISPR cleavage activity, as is common in the field. T cells electroporated with GS94-targeting CRISPR RNP showed no greater frequency of indels at the set of putative off-target sites than T cells treated with CRISPR RNP targeting other sites, consistent with the GS94-targeting CRISPR RNP having no consequential or detectable off-target activity, and therefore being the most specific out of the set evaluated (FIG. 41 ).

Potential effects of transgene integration at the GS94 site on the regulation of the T cell transcriptome were evaluated by knocking in a large cassette to the site, growing T cells for several days, sorting cells expressing the transgene within the cassette, and then collecting RNA from the cells. RNA-seq libraries were prepared and sequenced, and analysis of the resulting Illumina sequencing data revealed no biologically or statistically significant differences in expression of any genes within 300 kb of the GS94 site in cells with integrations at GS94 compared to cells with integration at TRAC or the GS102 sites (FIG. 42 ). Furthermore, other gene expression differences that reached statistical significance were minimal in number and in effect size, consistent with them being noise in the comparison.

To assess whether transgene integration at GS94 could confer a transformed phenotype, cells with integrations at the GS94 site were cultured with and without cytokines in vitro. Cells remained alive and viable with cytokine addition, but died without cytokine supplementation and lost their viability (FIG. 43 ). The positive control Jurkat cells remained viable and proliferated. Overall, this indicates that integration of a transgene at GS94 does not confer capacity for cytokine-independent growth, which is a hallmark of T cell transformation.

Example 10: In Vivo Insertion of a CAR Expressing Cassette

In vivo efficacy of T cells with a transgene cassette expressing a CAR recognizing a tumor antigen, or a CAR recognizing a tumor antigen under control of a priming receptor recognizing an antigen in the anatomical vicinity of the tumor, is assessed against human tumor cells such as K562 engineered to express the CAR antigen or to express antigens recognized by both the priming receptor and the CAR. Tumor cells (e.g. 1e6) are subcutaneously injected into the flank of NSG mice (Jackson Laboratories). Tumor growth is assessed by dimensional measurement by calipers every 2-4 days. When the tumor volume reaches ˜100 cubic mm, mice are intravenously injected with 5e6 T cells with a CAR or prime-CAR circuit cassette integrated at a specific site by CRISPR-mediated insertion, or with T cells engineered with CRISPR RNP alone, or with PBS alone as a sham injection. Tumor growth is monitored and mice are euthanized when tumor volume reaches 2000 cubic mm. Peripheral blood is bled from mice through a retro-orbital procedure, and flow cytometry and/or ddPCR is used to observe engineered T cell expansion over time. At time of sacrifice, spleen, blood, tumor and/or other tissue is analyzed via flow cytometry, ddPCR, and/or immunohistochemistry for the presence of engineered T cells. The results demonstrate that T cells engineered with cassette integration at one of the defined genomic loci lead to tumor regression and clearance in injected mice as compared to T cells without cassette integration, and that engineered T cells are detectable in the peripheral blood and tissues of injected mice.

REFERENCES

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TABLE 4 SGRNA SEQUENCES USED FOR EVALUATION OF PREDICTED LOCI Median (% Modified), sgRNA_ summarized start_ sgRNA Integra- from 2 sgRNA coor Target tion donors, 2 ID sgRNA Sequence GRCH38 Loci Site primersets sgRNA_ GCACCTGAATACCACGCCTG chr16: APRT APRT 79.28 1 (SEQ ID NO: 1)  88811818 sgRNA_ CGCCTGCGATGTAGTCGATG chr16: APRT APRT 78.60 2 (SEQ ID NO: 2)  88811551 sgRNA_ CAGGACGGGCGAGATGTCCC chr16: APRT APRT 85.25 3 (SEQ ID NO: 3)  88811640 sgRNA_ CTGAATCTTTGGAGTACCTG chr15: B2M B2M 78.51 4 (SEQ ID NO: 4)  44715425 sgRNA_ GGCCACGGAGCGAGACATCT chr15: B2M B2M 94.75 5 (SEQ ID NO: 5)  44711550 sgRNA_ AAGTCAACTTCAATGTCGGA chr15: B2M B2M 70.97 6 (SEQ ID NO: 6)  44715515 sgRNA_ GCTTGGAGGCCTGATCAGCG chr19: CAPNS1 CAPNS1 89.34 7 (SEQ ID NO: 7)  36141111 sgRNA_ CTTATCTCTTCGCAGCGAGG chr19: CAPNS1 CAPNS1 91.09 8 (SEQ ID NO: 8)  36142301 sgRNA_ CACACATTACTCCAACATTG chr19: CAPNS1 CAPNS1 71.98 9 (SEQ ID NO: 9)  36142676 sgRNA_ TTCCGCAAAATAGAGCCCCA chr3: CBLB CBLB 91.55 10 (SEQ ID NO: 10) 105746019 sgRNA_ TGCACAGAACTATCGTACCA chr3: CBLB CBLB 91.43 11 (SEQ ID NO: 11) 105751622 sgRNA_ GCAATAAGACTCTTTAAAGA chr3: CBLB CBLB 76.18 12 (SEQ ID NO: 12) 105853470 sgRNA_ CAAAGAGATTACGAATGCCT chr1: CD2 CD2 89.80 13 (SEQ ID NO: 13) 116754658 sgRNA_ CAAGGCACCCCAGGTTTCCA chr1: CD2 CD2 92.70 14 (SEQ ID NO: 14) 116754663 sgRNA_ TTACGAATGCCTTGGAAACC chr1: CD2 CD2 92.82 15 (SEQ ID NO: 15) 116754666 sgRNA_ CAGAGACGCATCTGACCCTC chr11: CD3E CD3E 90.96 16 (SEQ ID NO: 16) 118315540 sgRNA_ CATGCAGTTCTCACACACTG chr11: CD3E CD3E 87.47 17 (SEQ ID NO: 17) 118313715 sgRNA_ GTGTGAGAACTGCATGGAGA chr11: CD3E CD3E 86.65 18 (SEQ ID NO: 18) 118313715 sgRNA_ TCTCATTTCAGGAAACCACT chr11: CD3G CD3G 87.24 19 (SEQ ID NO: 19) 118349748 sgRNA_ AGTCATACACCTTAACCAAG chr11: CD3G CD3G 87.99 20 (SEQ ID NO: 20) 118349754 sgRNA_ TTCAAGGAAACCAGTTGAGG chr11: CD3G CD3G 86.55 21 (SEQ ID NO: 21) 118352458 sgRNA_ GAGCCTTGCCTGGAAATCTG chr11: CD5 CD5 84.03 22 (SEQ ID NO: 22)  61118177 sgRNA_ AAGCGTCAAAAGTCTGCCAG chr11: CD5 CD5 89.19 23 (SEQ ID NO: 23)  61118324 sgRNA_ CGTTCCAACTCGAAGTGCCA chr11: CD5 CD5 83.11 24 (SEQ ID NO: 24)  61118121 sgRNA_ GAGCGACTGGGACACGGTGA chr9: EDF1 EDF1 88.84 25 (SEQ ID NO: 25) 136866246 sgRNA_ GCTGCGCAAGAAGGGCCCTA chr9: EDF1 EDF1 91.04 26 (SEQ ID NO: 26) 136866211 sgRNA_ TTGTTCTGGCCAGCAGCCCC chr9: EDF1 EDF1 85.98 27 (SEQ ID NO: 27) 136863433 sgRNA_ CTTCCAGAGCCACATCATCG chr19: FTL FTL 93.10 28 (SEQ ID NO: 28)  48965791 sgRNA_ GGGACTCACCAGAGAGAGGT chr19: FTL FTL 88.86 29 (SEQ ID NO: 29)  48965601 sgRNA_ CGGTCGAAATAGAAGCCCTA chr19: FTL FTL 93.14 30 (SEQ ID NO: 30)  48965770 sgRNA_ AAAAGGATATTGTGCAACTG chr10: PTEN PTEN 92.37 31 (SEQ ID NO: 31)  87933015 sgRNA_ TGTGCATATTTATTACATCG chr10: PTEN PTEN 90.64 32 (SEQ ID NO: 32)  87933183 sgRNA_ TTTGTGAAGATCTTGACCAA chr10: PTEN PTEN 85.36 33 (SEQ ID NO: 33)  87933087 sgRNA_ TGTCATGCTGAACCGCATTG chr18: PTPN2 PTPN2 87.94 34 (SEQ ID NO: 34)  12830972 sgRNA_ CCACTCTATGAGGATAGTCA chr18: PTPN2 PTPN2 92.45 35 (SEQ ID NO: 35)  12859219 sgRNA_ TTGACATAGAAGAGGCACAA chr18: PTPN2 PTPN2 93.96 36 (SEQ ID NO: 36)  12836828 sgRNA_ GAGTACTACACTCAGCAGCA chr12: PTPN6 PTPN6 89.61 37 (SEQ ID NO: 37)   6952098 sgRNA_ TCACGCACAAGAAACGTCCA chr12: PTPN6 PTPN6 82.74 38 (SEQ ID NO: 38)   6954872 sgRNA_ AGGTCTCGGTGAAACCACCT chr12: PTPN6 PTPN6 91.27 39 (SEQ ID NO: 39)   6951610 sgRNA_ AGCATTATCCAAAGAGTCCG chr1: PTPRC PTPRC 88.88 40 (SEQ ID NO: 40) 198696873 sgRNA_ ATATTAATTCTTACCAGTGG chr1: PTPRC PTPRC 88.95 41 (SEQ ID NO: 41) 198692370 sgRNA_ AGCTTTAAATCAAGGTTCAT chr1: PTPRC PTPRC 96.89 42 (SEQ ID NO: 42) 198756176 sgRNA_ ATCCCGAGCCCTAAGGTGCA chr11: PTPRCAP PTPRCA 84.08 43 (SEQ ID NO: 43)  67436325 P sgRNA_ GGCAGCGCGGAGGACAGCGT chr11: PTPRCAP PTPRCA 97.74 44 (SEQ ID NO: 44)  67436285 P sgRNA_ CTCAGGGGGCTACTACCACC chr11: PTPRCAP PTPRCA 91.50 45 (SEQ ID NO: 45)  67436170 P sgRNA_ GTCACCGACGAGACCAGAAG chr5: RPS23 RPS23 79.40 46 (SEQ ID NO: 46)  82277810 sgRNA_ GTCGTGGACTTCGTACTGCT chr5: RPS23 RPS23 83.07 47 (SEQ ID NO: 47)  82277843 sgRNA_ TAATTTTTAGGCAAGTGTCG chr5: RPS23 RPS23 61.94 48 (SEQ ID NO: 48)  82277860 sgRNA_ TTAGCTGTTAGACTTGAATA chr14: RTRAF RTRAF 85.50 49 (SEQ ID NO: 49)  51993810 sgRNA_ CGAGAGCCGTCAACTTGCGT chr14: RTRAF RTRAF 85.64 50 (SEQ ID NO: 50)  51989652 sgRNA_ CGGCTTCAACTGCAAAGGTG chr14: RTRAF RTRAF 88.77 51 (SEQ ID NO: 51)  51989700 sgRNA_ TATGAAAAAGCAGAGCGACT chr15: SERF2 SERF2 89.61 52 (SEQ ID NO: 52)  43793025 sgRNA_ TCTGGCGGGCGAGCTCACGC chr15: SERF2 SERF2 86.73 53 (SEQ ID NO: 53)  43792989 sgRNA_ CTCACGCTGGTTACCGCCTA chr15: SERF2 SERF2 80.57 54 (SEQ ID NO: 54)  43792977 sgRNA_ AAAGATTACGAACTTCCCTG chr12: SLC38A1 SLC38A1 92.24 55 (SEQ ID NO: 55)  46207559 sgRNA_ GTTAAAAACAGACATGCCTA chr12: SLC38A1 SLC38A1 91.51 56 (SEQ ID NO: 56)  46229232 sgRNA_ ATGCCTAAGGAGGTTGTACC chr12: SLC38A1 SLC38A1 79.48 57 (SEQ ID NO: 57)  46229246 sgRNA_ CTCCAGGTATCCCATCGAAA chr18: SMAD2 SMAD2 79.53 58 (SEQ ID NO: 58)  47869418 sgRNA_ CACCAAATACGATAGATCAG chr18: SMAD2 SMAD2 86.61 59 (SEQ ID NO: 59)  47870532 sgRNA_ TGGCGGCGTGAATGGCAAGA chr18: SMAD2 SMAD2 82.91 60 (SEQ ID NO: 60)  47896729 sgRNA_ TAGGATGGTAGCACACAACC chr16: SOCS1 SOCS1 92.25 61 (SEQ ID NO: 61)  11255478 sgRNA_ CAGCAGCAGAGCCCCGACGG chr16: SOCS1 SOCS1 83.79 62 (SEQ ID NO: 62)  11255432 sgRNA_ CGGCGTGCGAACGGAATGTG chr16: SOCS1 SOCS1 84.24 63 (SEQ ID NO: 63)  11255296 sgRNA_ TATAGACGCTGCCCGACGTC chr15: SRP14 SRP14 95.12 64 (SEQ ID NO: 64)  40038895 sgRNA_ TCCAAAGAAGGGTACTGTGG chr15: SRP14 SRP14 92.14 65 (SEQ ID NO: 65)  40038368 sgRNA_ ACAGTACCCTTCTTTGGAAT chr15: SRP14 SRP14 65.82 66 (SEQ ID NO: 66)  40038358 sgRNA_ GCGACGGGCGCATCTACGTG chr12: SRSF9 SRSF9 83.68 67 (SEQ ID NO: 67) 120469572 sgRNA_ CCCGACCTCCATAAGTCCTG chr12: SRSF9 SRSF9 92.56 68 (SEQ ID NO: 68) 120465700 sgRNA_ GGGGTCCTCGAAGCGCACGA chr12: SRSF9 SRSF9 89.94 69 (SEQ ID NO: 69) 120469426 sgRNA_ TGCTCTGTTTAGAAGATGAC chr5: SUB1 SUB1 79.36 70 (SEQ ID NO: 70)  32591641 sgRNA_ ATATTCTTTTCTAGTTAAAG chr5: SUB1 SUB1 70.93 71 (SEQ ID NO: 71)  32591566 sgRNA_ CCTGTAAAGAAACAAAAGAC chr5: SUB1 SUB1 93.66 72 (SEQ ID NO: 72)  32591614 sgRNA_ TGGAGAAAGACGTAACTTCG chr4: TET2 TET2 83.53 73 (SEQ ID NO: 73) 105234315 sgRNA_ TCTGCCCTGAGGTATGCGAT chr4: TET2 TET2 90.97 74 (SEQ ID NO: 74) 105234747 sgRNA_ ATTCCGCTTGGTGAAAACGA chr4: TET2 TET2 89.62 75 (SEQ ID NO: 75) 105235656 sgRNA_ CAGGCACAATAGAAACAACG chr3: TIGIT TIGIT 92.65 76 (SEQ ID NO: 76) 114295571 sgRNA_ CCATTTGTAATGCTGACTTG chr3: TIGIT TIGIT 60.75 77 (SEQ ID NO: 77) 114295700 sgRNA_ CTGGGTCACTTGTGCCGTGG chr3: TIGIT TIGIT 87.99 78 (SEQ ID NO: 78) 114295634 sgRNA_ GTCAGGGTTCTGGATATCTG chr14: TRAC TRAC 98.20 79 (SEQ ID NO: 79)  22547508 sgRNA_ TGGATTTAGAGTCTCTCAGC chr14: TRAC TRAC 88.15 80 (SEQ ID NO: 80)  22547541 sgRNA_ CTGCGGCTGTGGTCCAGCTG chr14: TRAC TRAC 94.77 81 (SEQ ID NO: 81)  22550661 sgRNA_ ACAAAACTGTGCTAGACATG chr14: TRAC TRAC 87.86 82 (SEQ ID NO: 82)  22547658 sgRNA_ TTCTTCCCCAGCCCAGGTAA chr14: TRAC TRAC 89.85 83 (SEQ ID NO: 83)  22547778 sgRNA_ CGTCATGAGCAGATTAAACC chr14: TRAC TRAC 95.81 84 (SEQ ID NO: 84)  22550625 sgRNA_ GAGAGCGCCTGCGACCCGAG chr19: TRIM28 TRIM28 89.44 85 (SEQ ID NO: 85)  58544980 sgRNA_ CCAGCGGGTGAAGTACACCA chr19: TRIM28 TRIM28 94.79 86 (SEQ ID NO: 86)  58544869 sgRNA_ GGAGCGCTTTTCGCCGCCAG chr19: TRIM28 TRIM28 91.81 87 (SEQ ID NO: 87)  58544839 sgRNA_ TGAGGCCTGGACCTTATGCA chr10: chr10: desert_ 69.44 88 (SEQ ID NO: 88)  33134193  33130000- 1  33140000 (GS88) sgRNA_ CCTGGTGGAGTGAACCATGA chr10: chr10: desert_ 95.25 89 (SEQ ID NO: 89)  33132917  33130000- 1  33140000 (GS89) sgRNA_ CAAGCACTTAGGTTCCCCTG chr10: chr10: desert_ 91.13 90 (SEQ ID NO: 90)  33134633  33130000- 1  33140000 (GS90) sgRNA_ GGTCTCCCTACAATTCAGCG chr10: chr10: desert_ 92.02 91 (SEQ ID NO: 91)  72294568  72290000- 2  72300000 (GS91) sgRNA_ CACAGCGCGTGACTGCAATG chr10: chr10: desert_ 90.22 92 (SEQ ID NO: 92)  72298268  72290000- 2  72300000 (GS92) sgRNA_ TCTGGGGCACCAATTCTAGG chr10: chr10: desert_ 86.35 93 (SEQ ID NO: 93)  72292786  72290000- 2  72300000 (GS93) sgRNA_ GAGCCATGCTTGGCTTACGA chr11: chr11: desert_ 91.24 94 (SEQ ID NO: 94) 128342576 128340000- 3 128350000 (GS94) sgRNA_ GTACAAGTACTTATCTCATG chr11: chr11: desert_ 89.02 95 (SEQ ID NO: 95) 128343592 128340000- 3 128350000 (GS95) sgRNA_ GAGATAACAACATAACAACA chr11: chr11: desert_ 96.47 96 (SEQ ID NO: 96) 128347170 128340000- 3 128350000 (GS96) sgRNA_ CATATTCCATAGTCTTTGGG chr11: chr11: desert_ 88.54 97 (SEQ ID NO: 97)  65425000  65425000- 4  65427000 (GS97) (NEAT1) sgRNA_ CTGCCCCTTAGCAACTTAGG chr11: chr11: desert_ 92.76 98 (SEQ ID NO: 98)  65425507  65425000- 4  65427000 (GS98) (NEAT1) sgRNA_ TGTTTAAAAATATGTTGACA chr11: chr11: desert_ 90.76 99 (SEQ ID NO: 99)  65426264  65425000- 4  65427000 (GS99) (NEAT1) sgRNA_ CCAGGAATGGAAACTCACGC chr15: chr15: desert_ 87.84 100 (SEQ ID NO: 100)  92830315  92830000- 5  92840000 (GS100) sgRNA_ GAGGCCGCTGAATTAACCCG chr15: chr15: desert_ 85.32 101 (SEQ ID NO: 101)  92831850  92830000- 5  92840000 (GS101) sgRNA_ ATACACGCACACTTGCAGAA chr15: chr15: desert_ 99.92 102 (SEQ ID NO: 102)  92831131  92830000- 5  92840000 (GS102) sgRNA_ GAGCAGACAGAAACCCAGGG chr16: chr16: desert_ 87.92 103 (SEQ ID NO: 103)  11225670  11220000- 6  11230000 (GS103) sgRNA_ TGAGTCTCCAAACAGAACAG chr16: chr16: desert_ 88.53 104 (SEQ ID NO: 104)  11226284  11220000- 6  11230000 (GS104) sgRNA_ TAATATCACTGACTTCACGG chr16: chr16: desert_ 87.65 105 (SEQ ID NO: 105)  11225029  11220000- 6  11230000 (GS105) sgRNA_ TACACACAATGTAAGCAGCA chr2: chr2: desert_ 71.79 106 (SEQ ID NO: 106)  87467461  87460000- 7  87470000 (GS106) sgRNA_ GGGAGCTCAATTCGAAACCA chr2: chr2: desert_ 65.89 107 (SEQ ID NO: 107)  87468809  87460000- 7  87470000 (GS107) sgRNA_ TTGGACAGGTGAGACAGTCG chr2: chr2: desert_ 72.64 108 (SEQ ID NO: 108)  87467001  87460000- 7  87470000 (GS108) sgRNA_ AAGCTCACTCAGATAGTGTG chr3: chr3: desert_ 76.89 109 (SEQ ID NO: 109) 186511316 186510000- 8 186520000 (GS109) sgRNA_ CAGGAGAACCACCTTACACG chr3: chr3: desert_ 86.31 110 (SEQ ID NO: 110) 186515260 186510000- 8 186520000 (GS110) sgRNA_ GGACAGACCCTGATTCACAA chr3: chr3: desert_ 85.47 111 (SEQ ID NO: 111) 186519655 186510000- 8 186520000 (GS111) sgRNA_ ACATGGCAGTCTATGAACAG chr3: chr3: desert_ 87.77 112 (SEQ ID NO: 112)  59451154  59450000- 9  59460000 (GS112) sgRNA_ CCTATAGAGAGTACTACTTG chr3: chr3: desert_ 79.33 113 (SEQ ID NO: 113)  59456416  59450000- 9  59460000 (GS113) sgRNA_ CCAACCGGGTCTTCATTACG chr3: chr3: desert_ 92.21 114 (SEQ ID NO: 114)  59457029  59450000- 9  59460000 (GS114) sgRNA_ TCAAGCGTAGAGTTCCGAGT chr8: chr8: desert_ 93.07 115 (SEQ ID NO: 115) 127993006 127980000- 10 128000000 (GS115) sgRNA_ TCATGCAATTATGGACCCAG chr8: chr8: desert_ 89.40 116 (SEQ ID NO: 116) 127994663 127980000- 10 128000000 (GS116) sgRNA_ CGGGAAAGTGACTGGCCATG chr8: chr8: desert_ 87.45 117 (SEQ ID NO: 117) 127996766 127980000- 10 128000000 (GS117) sgRNA_ TGAGATTGAAATCAAATCGG chr9: chr9: desert_ 84.84 118 (SEQ ID NO: 118)   7974159   7970000- 11   7980000 (GS118) sgRNA_ TATGCAATATTCATCACGCG chr9: chr9: desert_ 85.44 119 (SEQ ID NO: 119)   7977914   7970000- 11   7980000 (GS119) sgRNA_ AATGTGTTAAATCAAATGCA chr9: chr9: desert_ 83.48 120 (SEQ ID NO: 120)   7976895   7970000- 11   7980000 (GS120)

TABLE 5 CONSTRUCTS USED FOR EVALUATION OF PREDICTED LOCI Construct name Sequence Length pARBI-903: ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC 1806 APRT_1_ GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC Endogenous_1 ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGCGTGGTATTCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCC CGACCTGCGGGCCTACGGATGGGAGCGCGTGGCCCGCGACCTCCGGGCGG GCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGG CCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGGGACATCTCGCCCGTCC TGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCGCGACAC CTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGAGTGCCC AGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCAC GTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGG GCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATT GAGCCC (SEQ ID NO: 123) pARBI-904: TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG 1806 APRT_2_ TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC Endogenous_2 TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCT TCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTT GGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGC TTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGC TGTGCAGGCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCG TGACCGAGTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATC CACAGGGCCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGA GCGCCTGCCACGAGCCAGGCCTTCCCTGGTGAAGATCACGGAATGCCCAC CCAGGGAAGGGAGGCCTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCA GGGAGA (SEQ ID NO: 124) pARBI-905: CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc 1806 APRT_3_ gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG Endogenous_3 CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGC CATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCG ACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCT CTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAG GGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTC GCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAG GCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGA GTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGG CCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTG CCACGA (SEQ ID NO: 125) pARBI-906: AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA 1806 B2M_1_ TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA Endogenous_4 TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGG AAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACA TTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCAT TCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACAC TGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATG TGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTT TTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTT TGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCA TCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAG ATCAGA (SEQ ID NO: 126) pARBI-907: AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC 1806 B2M_2_ CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG Endogenous_5 GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTC TGGCCTGGAGGCTATCCAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTC CTTCCTCTCCCGCTCTGCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCT CCGTGACTTCCCTTCTCCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAG TCCAGGGCTGGATCTCGGGGAAGCGGGGGGTGGCCTGGGAGTGGGGAAGG GGGTGCGCACCCGGGACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGG GGAGACCTTTGGCCTACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCG TCGATAAGCGTCAGAGCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCT TTCGCGGGGCCTCTGGCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAG GCTCG (SEQ ID NO: 127) pARBI-908: AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA 1806 B2M_3_ GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG Endogenous_6 CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAA AGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCT TGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGT GTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTC TTACATTCTTTTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCAT AAAGCTGCTTTGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAG TCCCATCCCATCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAAT GTTCTTAAAGATCAGATTAGTGGCACCTGCTGAGATACTGATGCACAGCA TGGTTTCTGAACCAGTAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAG CACTTG (SEQ ID NO: 128) pARBI-909: GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT 1806 CAPNS1_1_ GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG Endogenous_7 CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAGCGGGGCCGGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGG TGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAG TCATCAGCGCCATCAGGTAAGGCGGAGACTATCAGAGGGGGGGGCCTGGG AATGGGAGGAGCCTCAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAA ATAGAATAGGATTAACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGG GGAGGCCTGGTTTGAGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGC GGATATCAGTCATTGGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTG TGGGACCAGGACAATGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGG GTGGGGCTTATGGGTCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGA ACGTT (SEQ ID NO: 129) pARBI-910: CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC 1806 CAPNS1_2_ TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG Endogenous_8 CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGTAAGCCCCCT CTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGGTCCCATCCC TGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGAAATTCCTCT GCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGTCTTAGCCAT GCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTCTTTTCCTCA TCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTACCTGGGTTTG GGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGCTCTCCTCCC TTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTG AGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTA AGTAAC (SEQ ID NO: 130) pARBI-911: GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA 1806 CAPNS1_3_ CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG Endogenous_9 AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACT CTTTGCCCAGCTGGCTGGAGATGTAAGTAACCTGGGGTCCCTGGCCCCGT CCTAACCGTTCCATCCCTTCCCTTGTGGCTGCCCTTGCACACACACCCTT GACCATGACAATCCCAGTGTTCCCATTCTCCATGACATTCTCAGACCCCT TTCAGTCACCCCTGACCTGCCCCTAACTTCCGCCCGCAGGACATGGAGGT CAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACGTA AGTGACCGGGGTTAAGGAATAGGGTAGATTCAGAGGCAGAGGGGTCAGAG AGGATTTGACCTCTGGCCTCTGACTTTCAACCTGTTACCCACAGACCCTG ATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCC GTGATG (SEQ ID NO: 131) pARBI-912: ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac 1806 CBLB_1_ cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa Endogenous_10 gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGCTCTATTTTGCGGAATTGGAATTTCTTAGCTGTGACACATCC AGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGA AATATAGCACCAAACCCGGAAGGTAAGACTTTTTAGCAGTAATATTATGT GATATATCCAAAGATGAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCA GCAATACCCGCTGATGGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGA CCAAAATGGTGCTTCTTAACATAATGTTTTAAATTGATACATTGTGCTTA CTCTGAAACTTGGTATTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTG TTTTCATGATATCCGTGTTTATGTGCAAAATTGAATGTATATATTTGAAT ACTTGAATACTGTGCTAAAGAACAAATAAATAGAACAGTCTTATGTTCAT TACTTT (SEQ ID NO: 132) pARBI-913: CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC 1806 CBLB_2_ CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT Endogenous_11 TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC TTACTT (SEQ ID NO: 133) pARBI-914: TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG 1806 CBLB_3_ GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA Endogenous_12 GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGGTA AGAAGAATATTTCAGATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTT ACTTAATAGTTAACCTAAACGTCACCATGTAATTGTTTTGGGGTAAATGT GAGTCGCTTTGTATATagtcatgtggtacttaacgatggggatactttac aagaaatgcatttttagacaatttcattgttgtgtggacatgatagagtg tacttacacagagctagatggtattacctaccgcacacctaggctgtatg atgtagcctattgctcctaggctgcaaatctatacagtatgttactgtac tgaatactgtgggcagttgtaacacaatggtaagtatgtgtgtatctaaa tatacctaaacatagaaaaggtatggtaaaaatactgtataaaaggccgg gcgtgg (SEQ ID NO: 134) pARBI-915: AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC 1806 CD2_1_ AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA Endogenous_13_ TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT 14_15 GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGAAACCTGGGGTGCCTTGGGTCAGGACATCAACTTGGACATTCC TAGTTTTCAAATGAGTGATGATATTGACGATATAAAATGGGAAAAAACTT CAGACAAGAAAAAGATTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAG GAAAAAGATACATATAAGCTATTTAAAAATGGAACTCTGAAAATTAAGCA TCTGAAGACCGATGATCAGGATATCTACAAGGTATCAATATATGATACAA AAGGAAAAAATGTGTTGGAAAAAATATTTGATTTGAAGATTCAAGGTAAG TGTTCATTCCCTTAATTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGT TGGAAAATAGCATTTCTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGG GGGCTATACAGGAAACCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTG GTCCAA (SEQ ID NO: 135) pARBI-916: AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT 1806 CD3E_1_ TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC Endogenous_16 TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTGACCCTCTGGAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTC TCCAGTCCCCCTGCGACTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACG AGAGAGAATCGTTCCTCAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGA TCCCCCGCTCCCTCCTCCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAAT ATTGCTGCTTCCTCTTCCTTTGAAGCATCATCAGTAGTCACACCCTCACA GCTGGCCTGCCCTCTTGCCAGGATATTTATTTGTGCTATTCACTCCCTTC CCTTTGGATGTAACTTCTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAG TTGTCCCCCATCCCAAAGTATTCCATCTACTTTTCTATCGCCGTCCCCTT TTGCAGCCCTCTCTGGGGATGGACTGGGTAAATGTTGACAGAGGCCCTGC CCCGTT (SEQ ID NO: 136) pARBI-917: AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC 1806 CD3E_2_ TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT Endogenous_17_18 CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAACTGCATGGAGATGGATGTGATGTCGGTGGCCACAATTGTCAT AGTGGACATCTGCATCACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGA GCAAGAATAGAAAGGCCAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCT GGCGGCAGGCAAAGGGGTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCT GCCAAGGGGGACGACCAGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCT AGGTCAGAACAGCTTCTCTAGAGCTTCTATGCACAGCTTCTATTACTGTG ATGACAAGATCTCAACAGACGGTTTCAAATCTCACATCACTCCCCTCCTT CCCATCCTAGAAAAGTGCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCA CATACCTGTCAATGCCTGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGA AGAGAG (SEQ ID NO: 137) pARBI-918: ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT 1806 CD3G_1_ TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT Endogenous_19_20 CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTGGTTAAGGTGTATGACTATCAAGAAGATGGTTCGGTACTTCT GACTTGTGATGCAGAAGCCAAAAATATCACATGGTTTAAAGATGGGAAGA TGATCGGCTTCCTAACTGAAGATaaaaaaaaaTGGAATCTGGGAAGTAAT GCCAAGGACCCTCGAGGGATGTATCAGTGTAAAGGATCACAGAACAAGTC AAAACCACTCCAAGTGTATTACAGAAGTATGTAATCCCCTTTGGTCTGTT TGTTGTGAAATTAATCAGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGG GTGAAAGTGGAAATAGATCCTCAACAGTAATATTATCGCCTGTTCTCTTA ATTTCAGCTTGCCTCTTTTAAAATACTGTAAGATACTTCCCTCACCCTAT TGAAAAACTACAGCCAGTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCT CCATGG (SEQ ID NO: 138) pARBI-919: TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA 1806 CD3G_3_ CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT Endogenous_21 CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAGGAGGAATTGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAAT GCCAATTCTAATAAAGGACCCTTGCATCAACTGCCCTCGCAATTGCTTCT AAGTCTAGCTCCCTTCCCTAAGCGGCTATAAGCATCAGACTCTGGGGATC AGGGATTGGGACGTGGTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCA TACTGATTGTCTTGGCCTAGGTAAATATGAATTTTATGTATCTGTAAATC CTGTCAGAGCAGGGCCTCAAGCCATAGAGATGCTGAATATTAATCTTAAC CTACATTTGAATTTCTCATTATCTACACTATTAACATTTTGGGCTAATTA ATTATTTGTGATGAGGGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCA TCCCTGGCCTCTCTCCACCAGATGCTGGTAGATTGTCCAGTGTGACAATC AAAAAT (SEQ ID NO: 139) pARBI-920: GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG 1806 CD5_1_ GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA Endogenous_22 AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCA GCTGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCT GGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTC TGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGT CACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCT TCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTG ACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGG CGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAG GCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACA CATACC (SEQ ID NO: 140) pARBI-921: GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT 1806 CD5_2_ TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG Endogenous_23 TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCT TGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCT CCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGC CTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCT GGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAG CAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAG ACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGTAGGAT GGCAATGGAGGACCTAGTTCTGCCAATCACTGACTTCATCGTCGCCTCTG AACCTCCATTCTCCCATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAG GAGGCT (SEQ ID NO: 141) pARBI-922: tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt 1806 CD5_3_ aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA Endogenous_24 CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAGGGCCAGCTGGAGGTCTACCTCAAGGACGGATGGCACATGGT TTGCAGCCAGAGCTGGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTC AAGCGTCAAAAGTCTGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTT GGCCCCTTCCTTGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGG ACAACTGGGCTCCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTC ACTCTCTGGGCCTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGC ACCCTGGGCCTGGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATC TAGGGTCTGAGCAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAAC CACTCCCCAAGACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCC ATCTGT (SEQ ID NO: 142) pARBI-923: GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG 1806 EDF1_1_ TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG Endogenous_25 GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAA ATCCAAGCAGGTGCTTTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCG GACGCTgggccggggccacggaccgtggggcagggggctcggggaagggc aggcggggcctgggacagggcgcaggggacggggacaaggctggGGTGCC GGGGGCAGGACGGGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGA CCGGGCCAGGACaggggtgggaaggtggggggcggacccaggaggggatg gacggacccaggaggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGG GAACCGGACGGGGCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGG TGGGGCGGGGAGGGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGA GGACAG (SEQ ID NO: 143) pARBI-924: ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG 1806 EDF1_2_ GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC Endogenous_26 GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGT GCTTTGCTGACTGAGGAGCGGCCGGGCCGGGGGGGGCGGACGCTgggccg gggccacggaccgtggggcagggggctcggggaagggcaggcggggcctg ggacagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACG GGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGAC aggggtgggaaggtggggggcggacccaggaggggatggacggacccagg aggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGG GCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAG GGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAG GAGGTG (SEQ ID NO: 144) pARBI-925: CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC 1806 EDF1_3_ TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA Endogenous_27 CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTTCTAAAGAGAAGATGTGCTTTATACACATCAGCTCCACTAGG ACTGCTGCAAAACCAGGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAG GGCCCCTGGGGTACGCACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAG TGAGAGCCGGGCTGACCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCA GGGGGGTGGAGCCCACCCTCCCCGTGCTATCTGAACACCGGCCATCCCCC TCCCCAAACCCACAACCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGT GGCCAGGTCCTTCTGCGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCA CCTTGCCCACCTCCAGGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCC CGGTCCAGCTTGGCCGTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCC AGCAGC (SEQ ID NO: 145) pARBI-926: CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA 1806 FTL_1_ GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT Endogenous_2830 CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCGCGATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGA ATTGGCCGAGGAGAAGCGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAA ACCAGCGTGGCGGCCGCGCTCTCTTCCAGGACATCAAGGTAACTAGTGTG TGGGTAATGGACTACATCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGA TTTGAGGGCGTAGGTGTCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTT GTGAGCCCTCTTAACCGCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCA CAACACGCGGCAGTCCACACCGCTGCGTGGTCTTAGGGACGTATAGCTGT AAGAGCTAGGACAGGGTGCGGAGAGTGATAAATACAAGCTGTCACATGTC TTTGTGGCCTGGGCCTCTGACCCCCAACGACTCTTGGGAAATGTAGGTTT AGTTCT (SEQ ID NO: 146) pARBI-927: TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC 1806 FTL_2_ CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG Endogenous_29 CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCT CCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCG GTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCA TTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGACCGCGATGATG TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC GCTGGA (SEQ ID NO: 147) pARBI-928: CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT 1806 PTEN_1_ TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA Endogenous_31 GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACT TATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACA ATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTA ATGATATGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGA GGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTT ATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGA AAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATT GACAAGTAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATG TATGTGTATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACAT ATTCAT (SEQ ID NO: 148) pARBI-929: GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA 1806 PTEN_2_ ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT Endogenous_32 CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGG GGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCC TTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTC TTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATAT ATAAATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGT GAAATGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAA TTATTATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAAT TTTCAATTATACAATGTTATTATTAACTATAGTCACTATGCTGTCCAGTA GAGCTTCAGATCTTGTTCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCC CTGGAA (SEQ ID NO: 149) pARBI-930: ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG 1806 PTEN_3_ TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA Endogenous_33 CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTG TAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTAC ATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAA GTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTC CTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTT TTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATATATAA ATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGTGAAA TGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAATTAT TATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTC AATTAT (SEQ ID NO: 150) pARBI-931: TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG 1806 PTPN2_1_ ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag Endogenous_34 tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct gagaaaataaaagtcagttttgatcatttacaaccaaaaatcctaactaa cacaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCT TATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAAC AAGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctct ctctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCT GGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatATTGTGGAGAAAGAATCGGTGAGTAATATTTAATATTTACAACT TAGTATACTGTATGTGATCATTAGCATATAAAGATTTTCATTTTGGGGCC AATATTCATTCCTTAGTTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAA AGTGTTTCTGTCCGGAAAAACTCATGTATCCTTTTCCTTTCTTAAGTATT TTTATAACAATTGCAGACCTTTCATCTCCAAGATAGAAATACAATGGAAT AAATATGGACTAGCAGTGACATATAGATCTTTGGAATCCCTAGGAATCCT TATTGACCTATTGTCAATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTG TTCTACTTCAGATTTCTTACTTTATTCTACATTTCATAATTGCTGGTTTT TAATGATGATGAAAATTTCCTAATCCACTTCTAATTAGATGTGGCAATGA CATGCC (SEQ ID NO: 151) pARBI-932: CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT 1806 PTPN2_2_ TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT Endogenous_35 AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg accttggttcaatgctgggactgccacttactagctatgggatctttggt ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTATCCTCATAGAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAA CAGATACAGAGATGTAAGCCCATGTAAGTACTTGTGGGTTTGTGTGCATG TGTATTTTTTGGTTTGTTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCT TGGGGTCAGTGTTGATAAATACAGTAATTTTTTTCCTATTTACGTAAGAC ACGTTCTTTAAGAATTTAAAGGTGTAGAATAGTGGAAGGAAAAATAATTA CCCATAATTATTTCATCCTTCAAACATAGGCACCATTATTTTGGTGTATT TCCCACAACCTGTTTTTCTTATGCACAGTTTTCCTTTCTTTAAAATAATT GTAATTATAGATGTCTATATAATATCCATATGTATTTCCTTTTCATATCA TTCCATCCCCTTTGTAAGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGG TTTTTT (SEQ ID NO: 152) pARBI-933: ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT 1806 PTPN_3_ CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT Endogenous_36 ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAAAGGAGTTACATCTTAACACAGGCAAGTAATACGATACCACG CAAATGTCTGAAAATGATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGG TAAAAGTATATCTTGACTTCTTTTGGAAATGAAATGGTATTTCAGTTTTT TTCTGACGATGTAATGAATTATGGACATTATAAGGTTTTGAAGCTTTGAG TATTTAAGATAAAAGGCAAGTTATTTTTGATATTACACGTTCTGTGAAGG AAAATTCTTAGGAAATGGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCT TACATTATATCTGACACAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTT TCTCTTCCCATACCCTGTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTG TAGCTCCCCCTGCCTCGCATATATCTTCAGAGAGTACACCAAGCCCTGGA TGGTGT (SEQ ID NO: 153) pARBI-934: CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC 1806 PTPN6_1_ GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG Endogenous_37 CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAA GTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCA CCCCCGCCATTCCCAAGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCA GGGAGGCAGGGAGACTGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCC CTCCCTGCACCAGCTGGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGG GACCTGGTGTCTCAGAGCCTAACCTACCACCCTTTCCACCTAACCCCGAG GAAGCCACAGAAAGCTGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCA ACCCAGGTCCCACTGGAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTC GTGCAGGCCAGCTCTGTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGC CTGCCT (SEQ ID NO: 154) pARBI-935: CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT 1806 PTPN6_2_ GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT Endogenous_38 GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGT GCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCA GGGTCACCCACATCAAGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGG GGAGCCTCTGCTGAGGCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGA GGGTCTGCCTGGGCTTGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTC AAGTCCTGTGAATGGCCTAATTTGGCTCCCCCCAGGGTGGACGCTACACA GTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTT CAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC AGGTCAGGGGTGGGCCCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCC AGATGT (SEQ ID NO: 155) pARBI-936: TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT 1806 PTPN6_3_ GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT Endogenous_39 TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCT CAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGA ACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCC CGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCACTCATT CCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAA CCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCC CCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACC GACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCA TATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGA AGTTTG (SEQ ID NO: 156) pARBI-937: TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT 1806 PTPRC_1_ ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT Endogenous_40 ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACTCTTTGGATAATGCTAGTGCTTTTAATACCACAGGTTGGCA CACAAAAGTTGTTAACTTAAATATCAGGGAATGTCATTTAGAAAATTCTA CAGTTATCAGTACAACTTGTCTTTAAATTATTTGCACAGTTTCTAAGTAT GTGATTTTATTCAAGTGCAGAAATTGCAGGAAATTAGTATCTGTGAAATA TAGATCGACTGAAGTAATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAA AGAAGGGAAGCAAGATCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTA GTATCCTCTGATCTATACACACTCGCCATGATTCTCCCGCTTGGCTTCCC GCCACCTGGACAGATGAGAATTTCCCTAGTTCAGAGATTATCAGTTCTAC TCTCCTTGGAAGGTGTCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCAC TCTAGA (SEQ ID NO: 157) pARBI-938: AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT 1806 PTPRC_2_ GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA Endogenous_41 TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACTGGTAAGAATTAATATTTATATTTTTACTAATTTTATTTTCT TGTTGCAAAGTTTATATATTTAACTACAATTTTCTATTATTAACACTGAA ATTATTTTTAAGGATAAATTTTATAATCATGAGTGATTCTTGACATTCAC TTGTTCTTAAACTTTCTGCTTATACGTTATAGAGTTTAATAACTACCTAA ACATGTTATTAAATTTGTATATATATTTTGTGTATAAATAGTAACTTTTC CCAAACTTGACAGTAAATCACACAACAGGTTTCTACTCTCTTTTAATATT TTAAGACTATAAAAAAATGCATTTAAATTAGATAACAAAATTTTATAGTC TGAAAGCAGGTTAACAGCTGTCTATGTATGTTATAGATATGTAGATAACA GATTTGCATATGTCTATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGG TATGCA (SEQ ID NO: 158) pARBI-939: CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA 1806 PTPRC_3_ TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA Endogenous_42 GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTCATAGGAAAAGACATAAATGAGGAAACTCCAAACCTCCTGTTA GCTGTTATTTCTATTTTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGT GGATTAATTAAATGCAGCGAACCAATATTTGTAGAAGGGTTATATTTTAC TACTGTGGAAAAATATTTAAGATAGTTTTGCCAGAACAGTTTGTACAGAC GTATGCTTATTTTAAAATTTTATCTCTTATTCAGTAAAAAACAACTTCTT TGTAATCGTTATGTGTGTATATGTATGTGTGTATGGGTGTGTGTTTGTGT GAGAGACAGAGAAAGAGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTT GCTTTTCCTTTGTTTTTATGAAGAAAAAATACATTTTATATTAGAAGTGT TAACTTAGCTTGAAGGATCTGTTTTTAAAAATCATAAACTGTGTGCAGAC TCAATA (SEQ ID NO: 159) pARBI-940: aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat 1806 PTPRCAP_1_ agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt Endogenous_43 ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg agggatgggggctgatctcacagggccagagcctggttgaccaaataagg ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACCTTAGGGCTCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGG CTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTG TCctgctgctgctgctgctcctactgctgGCCACTGGCCTAGCACTGGCC TGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTACCACCCGGCCCGCCT AGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCC CAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACAATGAC CTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTCGCGGA TGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGG CGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGT GACACG (SEQ ID NO: 160) pARBI-941: aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc 1806 PTPRCAP_2_ catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca Endogenous_44 gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgctgct cctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTG ACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGC CGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGC CCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATG AGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGAC CCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGT CCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGG TCCTCGGCTCCCCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTG CTGAGT (SEQ ID NO: 161) pARBI-942: cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg 1806 PTPRCAP_3_ agtggtagggaggaggctggagggatgggggctgatctcacagggccaga Endogenous 45 gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCG CCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGC TGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACA GACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGG CGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGG CTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCC CCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCT GCACGCCTTTGCTGGCAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTG GGGGCCAGGGCCTCCATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCC CATCCC (SEQ ID NO: 162) pARBI-943: ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG 1806 RPS23_1_ GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA Endogenous_46 GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGC CCTAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGC TGGAAAAAGTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGG AATTCGAGACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTT TTTGTGTAGTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGT TTGTTCTATTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTA AGGTTTTAATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAA TGATGAAGTAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTA AATGGCACGTGTCAGCTATTGAACTTTATCGACTTGATAAAACTAAGGTG AAGAGA (SEQ ID NO: 163) pARBI-944: CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA 1806 RPS23_2_ GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC Endogenous_47_48 CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAA GTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGG CCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAA GTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAG ACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTA GTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTA TTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTA ATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAG TAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCAC GTGTCA (SEQ ID NO: 164) pARBI-945: TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA 1806RTRAF_1_ TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT Endogenous_49 GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTATGGAGATAATGGTACGTTTTGTGGGGAATGTGTATTTTAAAG AGAGAGGAAAGATGGGAAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGT TTGTTTTGTCTAGTACTATTTTACCTTTGGTTTATTCTTATCACAAGTTA AAAGCACTTTTATTGTCTTTCATTGGTGTTTATATATTTCTGTTAGAATT TGGAAATGGTGCCCTCTGGAGAAGGCTAATTGACTGTCTTCTCACAGAGT AACACTACTTTGATAATATGGTCTGCACCTTAGCCTTTCAAATTAAATTG TTTTTAGTGTCCCAGAATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGT AATTTCTCAAAAGACTGAAACATGTCTAATGCCAATATACATTAATACTC TATAGGCCAGAATATATTACTTATGTTTACTGTCTTAGCACAGATACTTC TATGGT (SEQ ID NO: 165) pARBI-946: GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA 1806 RTRAF_2_ CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC Endogenous_50 CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTG CAAAGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCG GAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGG CGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCA CGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCT ACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCA CGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACT CACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCAC CTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGT AACTTG (SEQ ID NO: 166) pARBI-947: CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA 1806 RTRAF_3_ GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG Endogenous_51 GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGG CGGAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTC GGCGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGC CACGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCAC CTACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCAT CACGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCA CTCACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGC ACCTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGA GTAACTTGAAGACTAGTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGG TGGAAG (SEQ ID NO: 167) pARBI-948: CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC 1806 SERF2_1_ CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC Endogenous_52 CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGC CGCCCGCAAGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGA GACCTGGGTTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGC TTGAATGTGGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGT TTTATTTCCTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAA GGACGGGGGCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGT CTGACCTTAAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTG GTTACGGCAGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCC CTTCTCCCAACCTCCTCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGA ATAGAG (SEQ ID NO: 168) pARBI-949: AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA 1806 SERF2_2_ GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC Endogenous_ CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG 53_54 AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAGCGCGAGCTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGA CTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCA AGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGG TTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGT GGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTC CTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGG GCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTT AAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGC AGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCC AACCTC (SEQ ID NO: 169) pARBI-950: TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT 1806 SLC38A1_1_ ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA Endogenous_55 ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGGAAGTTCGTAATCTTTGGAGCCACCTCTCTACAGAACACTGG AGGTAAAAAGAACATGCTTTTCTTTACATAACTTGAAACTAATTCTGGTG GATGAGCGGCCACATGAATTTTAACATAATTCAAGCAGTTATCATCCTCA TTGCTAAAATGGCACAGGGAAAGTAAAGCAGAGACAGCAGTCACTTATTT AAAGCCACAAATCCTGCTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTG ACAGTTGGTCTAAGAACGGGCTGATAACTTTTTATGTAGCTTGCAACATA AGCCTTCGTATCTTCTTTCTAAAAATGTTCTCATTTTCCTTCAGCAATGC TGAGCTACCTCTTCATCGTAAAAAATGAACTACCCTCTGCCATAAAGTTT CTAATGGGAAAGGAAGAGACATTTTCGTAAGTTATAGACCATTTTTTTAT GATATA (SEQ ID NO: 170) pARBI-951: TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA 1806 SLC38A1_2_ TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC Endogenous_56_57 AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTAGGCATGTCAGTTTTTAACCTAAGCAACGCCATTATGGGCAG TGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCTACTTT TTCTGTGAGTATTGACGTGCCGGTACTTTCCATTTTAAAACTGAACTTTT TGTATGTTTCTGTTATTACATAGAAGAAATGTGAAATATTTATAAATAGT TTTTTTATTAACTTGGCTAAGTTACAAGTACATACTTTGATATTTATTGC TTGAGTGATTTTCCAAACTGTACCTAATGCTTACAACAAAGAGGAAGGAG AAAATCTTTTTATTAATCAAAAATACTGAAATAAGCATTTGTGAAAAGGA TTAAAACATTTGAAAATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTG ACTTTAAATCTCAGTTAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCA CCACTT (SEQ ID NO: 171) pARBI-952: ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT 1806 SMAD2_1_ TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA Endogenous_58 AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAAAGGATTGCCACATGTTATATATTGCCGATTATGGCGCTGGCC TGATCTTCACAGTCATCATGAACTCAAGGCAATTGAAAACTGCGAATATG CTTTTAATCTTAAAAAGGATGAAGTATGTGTAAACCCTTACCACTATCAG AGAGTTGAGACACCAGGTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGA ATTAAATGCCTGAACTTCAGTATATTTAAGTACTCTTGTGACCCAGGAAA ATTTTAGTGTAAATTCTAATAAATTACCTTAAATTGTGCATATTATTTGG TGGTAATTAAAAtttttttatttttaaaaatttttAATGAGAAAACATAT CTGTTTCTTGGAATAGCATATGATTTGGCATGAAAGTGCATATCCAGGAA ATCCTGTAGATTGGCAGTCTGCTCAGCGCTATGCTGATGTGCTTCTACAT GTCCCT (SEQ ID NO: 172) pARBI-953: TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA 1806 SMAD2_2_ ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG Endogenous_59 ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCAGTGGGATACAACAGGCCTTTACAGCTTCTCTGAACAAACCAG GTGAATATTCTGCCCTCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGT ATATTTTGAAAGACCTATATGGGGTTGCTTAGTATAATTTTGCCTAGGAT GTTTCCTTAATGTAAAATAAGGCATAGCATTTAAAATATCTGCTTGCCAG TATAAAAAATATATTAAATGTTTCAGCTGATGTTTTAATCAATGCAATTC TAGTTTGAATCTTCTTTAAATTACTGTATCCCCTAAAGAATAATAATTTT GATAACTATATATTTATTTTAGCTTGAGATCAGATTATAATCTGTTGTTG GCCTAATTTTTAAGTAGATACATGATGAGTTTTGCTAAATTTCTTGTTAT CAGAATCTCATCTTTATACTAATAAATACATACTTAATGAACCCCTTATA TCACAA (SEQ ID NO: 173) pARBI-954: TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG 1806 SMAD2_3_ TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA Endogenous_60 AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTGCCATTCACGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAA GAAGTCAGCTGGTGGGTCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGC AGGAAGAAAAGTGGTGTGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTA AAGAAAACAGGACGATTAGATGAGCTTGAGAAAGCCATCACCACTCAAAA CTGTAATACTAAATGTGTTACCATACCAAGGTAAGTTTTGTTAGATCCCA GGTTTGATCAAATTATGTCAAGGAATCTGAAGGAAAGTTACTGAATTTGT GTTCCTTTCAAGTTGCCTGTAAAAAGTGATGATTGAAATATGACTGTTTT TAACCTTGTATAAATTGTTTTTGCTAGCTGACTTGTTTTATAAATTATTT TCTTGAATAGTGAGGTTTAATCAAGCTAAATAAGATACTTAGATTTATTA TCTTCA (SEQ ID NO: 174) pARBI-955: GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC 1806 SOCS1_1_ CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGGGCGAGC Endogenous_61 CGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCT CGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCG GGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAG GCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCC GGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCT GCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCA CCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGt ccggatccggagagggcaggggatctctccttacttgtggcgacgtggag gagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGT GGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCA GCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTG AAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGT GACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACA TGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAG GAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGA GGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCA TCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAAC TACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCAT CAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGC TCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTG CTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCC CAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCG GGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagct tataatggttacaaataaagcaatagcatcacaaatttcacaaataaagc atttttttcactgcattctagttgtggtttgtccaaactcatcaatgtat cttatGTAGCACACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCA GCAGAGCCCCGACGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcc cgcggcccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCC CCGGCGACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGC ATCACGCGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCC CCTGAGCGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCA CCTTCCTGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGC GTGAAGATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGG CCGCTTTCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGC TGCTG (SEQ ID NO: 175) pARBI-956: GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC 1806 SOCS1_2_ CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC Endogenous_62 TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggc ccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCCCCGGCG ACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACG CGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAG CGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCC TGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAG ATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTT TCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGG AGCACTACGTGGCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAG CGCCGC (SEQ ID NO: 176) pARBI-957: CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG 1806 SOCS1_3_ TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC Endogenous_63 GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGC GCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGG CGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGAC AGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGG ACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATG GCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTG GCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCG GCCGCTGCAGGAGCTGTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCG AGAACCTGGCTCGCATCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGC TCCTTC (SEQ ID NO: 177) pARBI-958: GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC 1806 SRP14_1_ AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG Endogenous_64 GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGACGCTGCCCGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCT CCGTCAGGAACTGGAAAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAA TCCTCGTCCTGCCGCGTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGT CTCGAGTAACGCCTGAGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCC ATACCTGCTCGCTCTCCAACAACACCATCGCGGCGACGCTGGCTCGACTC CCTCCGCTTAAGCCCCTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGG GGGGACTTCCGCTACTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTT CCACCAATCCCGGCCTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCG CGCCCTGGGACGTCCGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCT GGGTC (SEQ ID NO: 178) pARBI-959: GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC 1806 SRP14_2_ TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG Endogenous_ CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC 65_66 CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTT AAGAGCTACCGATGGGAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTT CTAAGGCTGTCTTTTGAAATGTAAAGACTTGAACTTAACAGAGGATGGGG CGTTTCTGAACCAGGCTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCT ATTTTTGAGACCAGGACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAA TAAAATAAGAAGGTAGAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTT GTGGAAATGAAAGTAGCATATTGGTCCTTATTCGTAGTACTGTAAGGAGC AGCTGGCATAAATATTTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCA ATAAGCAGTTTCTTGGTACCAGGTGATGCTATTATTTCCTTATCTTTGTG GTTCAC (SEQ ID NO: 179) pARBI-960: CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG 1806 SRSF9_1_ AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG Endogenous_67 CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGTGGGGAACCTTCCGACCGACGTGCGCGAGAAGGACTTGGAGGA CCTGTTCTACAAGTACGGCCGCATCCGCGAGATCGAGCTCAAGAACCGGC ACGGCCTCGTGCCCTTCGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGc ccccgcgcccctgccctctcctcctcggtgcctgaggcccccgccttccc tgctgtcccctcccccagggctcccctccccccggcctcccctccccccg cctccgcgcagacccctcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCA GCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTT ATTTTTATTATTCCAATATTTTACTTAGAAACCCAAAAGCTGAGCCTTTG GAGGGCCCAAGCCCGCCTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTG TCCGCC (SEQ ID NO: 180) pARBI-961: TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT 1806 SRSF9_2_ GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT Endogenous_68 CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACTTATGGAGGTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGG GCCTCCTACAAGAAGATCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCC TTTCAAACAGaatgagatgatacatgtaaaatacttaacacagagtctgt cttccaagaaatgatagctgttattcttCAGTGCATGGGACACGGGGGCT TTCTTTTCAATAGCCTGTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAA AGTATCCTGCAAATGAAATTGCGCTGGGAGTGCAGCCTTGGAAGAACATA ACCATATTTCTTGTAAAGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATG GGAAAACTTGAGCTACAATTCTAAAGATGCTTCTTTTGGAATATACTTGG CATCAGACATGGTAGAAAGGCATTCAAGGAGCCAGATTTGAACAACTTAC CCAGCC (SEQ ID NO: 181) pARBI-962: GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG 1806 SRSF9_3_ GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG Endogenous_69 CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccct ctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccca gggctcccctccccccggcctcccctccccccgcctcegcgcagacccct caCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCC CGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAAT ATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCC TGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGG GCAGCACCGTAGGGGGAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTC GCCCTTCCCGCTCGCCTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAG CAAGCT (SEQ ID NO: 182) pARBI-963: GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA 1806 SUB1_1_ GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC Endogenous_70 CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTCTTCTAAACAGAGCAGCAGCAGCAGAGATGATAACATGTTTCA GGTAAAGTTGGCTAttttttttttttttttttttgacatggagtcatgct ctgtcacccaggctggagtgcagtggcgccatctcggctcactgcaacct cagcctcctgagttcaagcagttctctgcctcagcctcccgagtagctag gattacaggcatccgccaccagacctggctaatttttgtatttttagtag agatggggtttcaccatcttggccaggctggtcttgaactcctgaccttg tgatccaactgcctcagcctccaaaagtgctgggtttacaggtgtgagcc accatgccttgccAAAGTTGGCTGTTTCTTTAGATTCAGAGGAATTATTA TCTGGCTTGATCTGAAGAATGTTAAAAGTACTATGATCTGATAATTGCCT AATATG (SEQ ID NO: 183) pARBI-964: ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA 1806 SUB1_2_ TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG Endogenous_71 TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACA AAAGACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCA GCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTT TTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTG GCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCT CTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACC TGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCA GGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAA AGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGT TTCTTT (SEQ ID NO: 184) pARBI-965: AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC 1806 SUB1_3_ TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT Endogenous_72 CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAG CAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTT TTTTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAG TGGCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTT CTCTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGA CCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGC CAGGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCA AAAGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCT GTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAAGAATGTT AAAAGT (SEQ ID NO: 185) pARBI-966: CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG 1806 TET2_1_ CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC Endogenous_73 ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACC AAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCC AAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACACATAACTGCAGT GGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAG TGCTAATTACCATGACAAGAACATTGTATTACTTAAAAACAAGGCAGTGC TAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTGGAACACACACAT GGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCCAGATTGTGTTTC CATTGCGGTGCAGAAAACCACATCTCACATAAATGCCATTAACAGTCAGG CTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCGCATACCTCAGGG CAGATC (SEQ ID NO: 186) pARBI-967: AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA 1806 TET2_2_ AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA Endogenous_74 GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCATACCTCAGGGCAGATCAATTCCGCACAGACCTCTAACTCTGA GCTGCCTCCAAAGCCAGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATG ATGCTGATAATGCCAGTAAACTAGCTGCAATGCTAAATACCTGTTCCTTT CAGAAACCAGAACAACTACAACAACAAAAATCAGTTTTTGAGATATGCCC ATCTCCTGCAGAAAATAACATCCAGGGAACCACAAAGCTAGCGTCTGGTG AAGAATTCTGTTCAGGTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGC TCTGAACGGTATTTAAAACAAAATGAAATGAATGGTGCTTACTTCAAGCA AAGCTCAGTGTTCACTAAGGATTCCTTTTCTGCCACTACCACACCACCAC CACCATCACAATTGCTTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCT CAGCTT (SEQ ID NO: 187) pARBI-968: GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC 1806 TET2_3_ CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC Endogenous_75 CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTTCACCAAGCGGAATCCCATCTAAAACGTAATGAGGCATCACT GCCATCAATTCTTCAGTATCAACCCAATCTCTCCAATCAAATGACCTCCA AACAATACACTGGAAATTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCT TACACCCAGAAAACAACACAGCTGGAGCACAAGTCACAAATGTACCAAGT TGAAATGAATCAAGGGCAGTCCCAAGGTACAGTGGACCAACATCTCCAGT TCCAAAAACCCTCACACCAGGTGCACTTCTCCAAAACAGACCATTTACCA AAAGCTCATGTGCAGTCACTGTGTGGCACTAGATTTCATTTTCAACAAAG AGCAGATTCCCAAACTGAAAAACTTATGTCCCCAGTGTTGAAACAGCACT TGAATCAACAGGCTTCAGAGACTGAGCCATTTTCAAACTCACACCTTTTG CAACAT (SEQ ID NO: 188) pARBI-969: AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG 1806 TIGIT_1_ CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC Endogenous_76 AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACGGGGAACATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACA ATGTCACCTCTCCTCCACCACGGCACAAGTGACCCAGGTCAACTGGGAGC AGCAGGACCAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATC TCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCAC CCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCATCTATC ACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTA GAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCT CTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAAT TCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACTGATGCC GAGGCC (SEQ ID NO: 189) pARBI-970: GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA 1806 TIGIT_2_ GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG Endogenous_77 GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGG TGATTCTAATGGGCAGCCAATACTGAGAACCACTGTTCTTATGTAAGAAG CACATC (SEQ ID NO: 190) pARBI-971: CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA 1806 TIGIT_3_ TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT Endogenous_78 GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCT TCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCA AGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTG ACCGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGA TGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTA TTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAA TGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATT TGAATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCCTCACCCA GACCAATTCAATCAGAATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTC TAAAAG (SEQ ID NO: 191) pARBI-972: TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG 1806 TRAC_1_ TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT Endogenous_79 ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAA ATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAA ATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTG CTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG TCCAGA (SEQ ID NO: 192) pARBI-973: GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC 1806 TRAC_2_ TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA Endogenous_80 ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGA TTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATA TCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAAGAGCAAC AGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTT CAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGG GCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGG TTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGG TCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGT GAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAA GAGAAG (SEQ ID NO: 193) pARBI-974: TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT 1806 TRAC_3_ GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT Endogenous_81 AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTGAGGTGAGGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCG GGTCTCTGGGTGCATCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCT TGCTTTTAAGTCCAAAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTG TTACAAATTCCTCTTGTGCAATAATAATGGCCTGAAACGCTGTAAAATAT CCTCATTTCAGCCGCCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAA CAGTTGTTTAGAAACGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGG AAGAGAGACACTTGTGTACACCACATGCCTTGTGTTGTACTTCTCTCACC GTGTAACCTCCTCATGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGT AGAAAGAAGACATTACACTCATATTACACCCCAATCCTGGCTAGAGTCTC CGCACC (SEQ ID NO: 194) pARBI-975: ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC 1806 TRAC_4_ TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC Endogenous_82 TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG TCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGA GGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGC CTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAG CCCCTT (SEQ ID NO: 195) pARBI-976: TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG 1806 TRAC_6_ GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC Endogenous_84 TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGA GGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCA TCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCA AAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCT TGTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCG CCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAA CGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTG TGTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCA TGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATT ACACTC (SEQ ID NO: 196) pARBI-977: CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC 1806 TRAC_ ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT Endogenous_83 GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTC AGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTC CTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTT ACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAA AAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCA GTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCC CCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTC TCCTTATTTCTCCCTGTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCA GTCTCACGCAGTCACTCATTAACCCACCAATCACTGATTGTGCCGGCACA TGAATG (SEQ ID NO: 197) pARBI-978: TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG 1806 TRIM28_1_ GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG Endogenous_85 CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGAGAGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAG TGCCTGCTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACG GCGGGGCGGCGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACC CCTCCCCCTACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGAT GCCACCTGGGCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTT CTGGGTCCTGCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACA TCTGACTAAAGTTGGAGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTC GCTGCGGGATAATGGTCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCC ATAACCTGGGTGGGAACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAA GTGGTG (SEQ ID NO: 198) pARBI-979: TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC 1806 TRIM28_2_ ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA Endogenous_86 CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatACCAAGGACCATACTGTGCGCTCTACTGGTACATGAGGCTGAGG GGGGCTGTTGGAGTTGTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGAT GTTGGTTGCATCTGGTGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCC CGAAGGGCCCGAGGGCAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGT GTGTAGTCTCTAGGGCCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGG AGACCTTAATGTGCTGCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCA GGGAGTTGTCAGACCTGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAA AGGCATGGTGTGAAGGGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCT GGTATAAGATGCTGCTAGGGAAAGTAGACTGTGGGTCCATGGATTATAAG TGATGA (SEQ ID NO: 199) pARBI-980: GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC 1806 TRIM28_3_ GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG EndogenouS_87 TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGC CTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGC TGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAG AGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTT AGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGG CGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCT ACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGG GCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCT GCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAA AGTTGG (SEQ ID NO: 200) pARBI-596: ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC 2541 APRT_1_ GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC Exogenous_1 ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGGCGTGGTAT TCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTAC GGATGGGAGCGCGTGGCCCGCGACCTCCGGGGGGCGGGGCGGGAACCCTC GTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGC CTGTCCTTGGGTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCC TTCCGCGCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGG GGGCCGCATCGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGG CGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCT GCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCC GTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCC (SEQ ID NO: 201) pARBI-597: TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG 2541 APRT_2_ TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC Exogenous_2 TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGACTACATC GCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGC GCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTG GGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGA AGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTT CCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGG GTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTG CCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGAGC CAGGCCTTCCCTGGTGAAGATCACGGAATGCCCACCCAGGGAAGGGAGGC CTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCAGGGAGA (SEQ ID NO: 202) pARBI-598: CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc 2541 APRT_3_ gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG Exogenous_3 CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGACATCTCGC CCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCG CGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGA GTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGG CAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTT CAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGT GAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTTCCCGCAGG TTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGGGTCAGTTG GTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTGCCTTGCTT CTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGA (SEQ ID NO: 203) pARBI-599: AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA 2541 B2M_1_ TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA Exogenous_4 TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACTCCAAAG ATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCT GAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTAC TGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTC AGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCAC TGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGC CCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTAAGCTGCTGAA AGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATATAAAAAAGGT CTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGATATAAACAAT CTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAGA (SEQ ID NO: 204) pARBI-600: AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC 2541 B2M_2_ CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG Exogenous_5 GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTCGCTCCG TGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCTATC CAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTCCTTCCTCTCCCGCTCT GCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCTCCGTGACTTCCCTTCT CCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAGTCCAGGGCTGGATCTC GGGGAAGCGGCGGGGTGGCCTGGGAGTGGGGAAGGGGGTGCGCACCCGGG ACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGGGGAGACCTTTGGCCT ACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCGTCGATAAGCGTCAGA GCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCTTTCGCGGGGCCTCTG GCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAGGCTCG (SEQ ID NO: 205) pARBI-601: AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA 2541 B2M_3_ GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG Exogenous_6 CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGACATTGAA GTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGA CTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAAT TCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACT TTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTA AGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATA TAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGA TATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAG ATTAGTGGCACCTGCTGAGATACTGATGCACAGCATGGTTTCTGAACCAG TAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAGCACTTG (SEQ ID NO: 206) pARBI-602: GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT 2541 CAPNS1_1_ GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG Exogenous_7 CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAGCGGGGCC GGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGG TGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCA GGTAAGGCGGAGACTATCAGAGGGGCGGGGCCTGGGAATGGGAGGAGCCT CAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAAATAGAATAGGATTA ACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGGGGAGGCCTGGTTTG AGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGCGGATATCAGTCATT GGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTGTGGGACCAGGACAA TGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGGGTGGGGCTTATGGG TCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGAACGTT (SEQ ID NO: 207) pARBI-603: CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC 2541 CAPNS1_2_ TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG Exogenous_8 CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACAT CGCCCACAGTCCCCGAGAAGTTGGGGGGAGGGGTCGGCAATTGAACGGGT GCCTAGAGAAGGTGGCGCGGGGTAAACTGGGAAAGTGATGTCGTGTACTG GCTCCGCCTTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAG TCGCCGTGAACGTTCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGCTG AAGCTTCGAGGGGCTCGCATCTCTCCTTCACGCGCCCGCCGCCCTACCTG AGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCTCCCGCCTGTG GTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAAGCTCAGGTCG AGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTAGACTCAGCCG GCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTACGTCTTTGTTT CGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACCGGCGCCTACT CTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGCGAGGAGCTGT TCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGC CACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAA GCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGC CCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTAC CCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGG CTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGA CCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAG CTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCT GGAGTACAACTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGA AGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGC AGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGG CCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGA GCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTG ACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtt tattgcagcttataatggttacaaataaagcaatagcatcacaaatttca caaataaagcatttttttcactgcattctagttgtggtttgtccaaactc atcaatgtatcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGT AAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGG TCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGA AATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGT CTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTC TTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTAC CTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGC TCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCA ACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCT GGAGATGTAAGTAAC (SEQ ID NO: 208) pARBI-604: GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA 2541 CAPNS1_3_ CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG Exogenous_9 AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCC GCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCT CCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAA GCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTA GACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTAC GTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACC GGCGCCTACTCTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGC GAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGA CGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCA CCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCC GTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTT CAGCCGCTACCCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCA TGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGC AACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAA CCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGG GGCACAAGCTGGAGTACAACTACAACAGCCACAACGTCTATATCATGGCC GACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACAT CGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCA TCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAG TCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCT GGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACA Aatgattgtttattgcagcttataatggttacaaataaagcaatagcatc acaaatttcacaaataaagcatttttttcactgcattctagttgtggttt gtccaaactcatcaatgtatcttatATTGAGGCCAACGAGAGTGAGGAGG TCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTAAGTAAC CTGGGGTCCCTGGCCCCGTCCTAACCGTTCCATCCCTTCCCTTGTGGCTG CCCTTGCACACACACCCTTGACCATGACAATCCCAGTGTTCCCATTCTCC ATGACATTCTCAGACCCCTTTCAGTCACCCCTGACCTGCCCCTAACTTCC GCCCGCAGGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAAT AAGGTTGTGACACGACGTAAGTGACCGGGGTTAAGGAATAGGGTAGATTC AGAGGCAGAGGGGTCAGAGAGGATTTGACCTCTGGCCTCTGACTTTCAAC CTGTTACCCACAGACCCTGATCTGAAGACTGATGGTTTTGGCATTGACAC ATGTCGCAGCATGGTGGCCGTGATG (SEQ ID NO: 209) pARBI-605: ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac 2541 CBLB_1_ cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa Exogenous_10 gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGCTCTATT TTGCGGAATTGGAATTTCTTAGCTGTGACACATCCAGGTTACATGGCATT TCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAAC CCGGAAGGTAAGACTTTTTAGCAGTAATATTATGTGATATATCCAAAGAT GAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCAGCAATACCCGCTGAT GGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGACCAAAATGGTGCTTC TTAACATAATGTTTTAAATTGATACATTGTGCTTACTCTGAAACTTGGTA TTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTGTTTTCATGATATCCG TGTTTATGTGCAAAATTGAATGTATATATTTGAATACTTGAATACTGTGC TAAAGAACAAATAAATAGAACAGTCTTATGTTCATTACTTT (SEQ ID NO: 210) pARBI-606: CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC 2541 CBLB_2_ CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT Exogenous_11 TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC TTACTT (SEQ ID NO: 211) pARBI-607: TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG 2541 CBLB_3_ GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA Exogenous_12 GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGAAGGCAAG GAGAGAATGTATGAAGAACAGTCACAGGACAGGTAAGAAGAATATTTCAG ATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTTACTTAATAGTTAACC TAAACGTCACCATGTAATTGTTTTGGGGTAAATGTGAGTCGCTTTGTATA Tagtcatgtggtacttaacgatggggatactttacaagaaatgcattttt agacaatttcattgttgtgtggacatgatagagtgtacttacacagagct agatggtattacctaccgcacacctaggctgtatgatgtagcctattgct cctaggctgcaaatctatacagtatgttactgtactgaatactgtgggca gttgtaacacaatggtaagtatgtgtgtatctaaatatacctaaacatag aaaaggtatggtaaaaatactgtataaaaggccgggcgtgg (SEQ ID NO: 212) pARBI-608: AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC 2541 CD2_1_ AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA Exogenous_13_ TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT 14_15 GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGAAACCTGG GGTGCCTTGGGTCAGGACATCAACTTGGACATTCCTAGTTTTCAAATGAG TGATGATATTGACGATATAAAATGGGAAAAAACTTCAGACAAGAAAAAGA TTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAGGAAAAAGATACATAT AAGCTATTTAAAAATGGAACTCTGAAAATTAAGCATCTGAAGACCGATGA TCAGGATATCTACAAGGTATCAATATATGATACAAAAGGAAAAAATGTGT TGGAAAAAATATTTGATTTGAAGATTCAAGGTAAGTGTTCATTCCCTTAA TTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGTTGGAAAATAGCATTT CTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGGGGGCTATACAGGAAA CCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTGGTCCAA (SEQ ID NO: 213) pARBI-609: AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT 2541 CD3_ TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC E_1_ TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT Exogenous_16 AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTGACCCTCTG GAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTCTCCAGTCCCCCTGCGA CTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACGAGAGAGAATCGTTCCT CAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGATCCCCCGCTCCCTCCT CCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAATATTGCTGCTTCCTCTT CCTTTGAAGCATCATCAGTAGTCACACCCTCACAGCTGGCCTGCCCTCTT GCCAGGATATTTATTTGTGCTATTCACTCCCTTCCCTTTGGATGTAACTT CTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAGTIGTCCCCCATCCCAA AGTATTCCATCTACTTTTCTATCGCCGTCCCCTTTTGCAGCCCTCTCTGG GGATGGACTGGGTAAATGTTGACAGAGGCCCTGCCCCGTT (SEQ ID NO: 214) pARBI-610: AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC 2541 CD3_E_2_ TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT Exogenous_17_18 CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatAACTGCATGG AGATGGATGTGATGTCGGTGGCCACAATTGTCATAGTGGACATCTGCATC ACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGAGCAAGAATAGAAAGGC CAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCTGGCGGCAGGCAAAGGG GTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCTGCCAAGGGGGACGACC AGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCTAGGTCAGAACAGCTTC TCTAGAGCTTCTATGCACAGCTTCTATTACTGTGATGACAAGATCTCAAC AGACGGTTTCAAATCTCACATCACTCCCCTCCTTCCCATCCTAGAAAAGT GCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCACATACCTGTCAATGCC TGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGAAGAGAG (SEQ ID NO: 215) pARBI-611: ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT 2541 CD3G_1_ TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT Exogenous_19_20 CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGGTTAAGG TGTATGACTATCAAGAAGATGGTTCGGTACTTCTGACTTGTGATGCAGAA GCCAAAAATATCACATGGTTTAAAGATGGGAAGATGATCGGCTTCCTAAC TGAAGATaaaaaaaaaTGGAATCTGGGAAGTAATGCCAAGGACCCTCGAG GGATGTATCAGTGTAAAGGATCACAGAACAAGTCAAAACCACTCCAAGTG TATTACAGAAGTATGTAATCCCCTTTGGTCTGTTTGTTGTGAAATTAATC AGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGGGTGAAAGTGGAAATAG ATCCTCAACAGTAATATTATCGCCTGTTCTCTTAATTTCAGCTTGCCTCT TTTAAAATACTGTAAGATACTTCCCTCACCCTATTGAAAAACTACAGCCA GTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCTCCATGG (SEQ ID NO: 216) pARBI-612: TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA 2541 CD3G_3_ CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT Exogenous_21 CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAGGAGGAAT TGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAATGCCAATTCTAATAAA GGACCCTTGCATCAACTGCCCTCGCAATTGCTTCTAAGTCTAGCTCCCTT CCCTAAGCGGCTATAAGCATCAGACTCTGGGGATCAGGGATTGGGACGTG GTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCATACTGATTGTCTTGG CCTAGGTAAATATGAATTTTATGTATCTGTAAATCCTGTCAGAGCAGGGC CTCAAGCCATAGAGATGCTGAATATTAATCTTAACCTACATTTGAATTTC TCATTATCTACACTATTAACATTTTGGGCTAATTAATTATTTGTGATGAG GGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCATCCCTGGCCTCTCTC CACCAGATGCTGGTAGATTGTCCAGTGTGACAATCAAAAAT (SEQ ID NO: 217) pARBI-613: GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG 2541 CD5_1_ GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA Exogenous_22 AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCAGGCA AGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCTGGAGGTCTACCT CAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGGGCCGGAGCTCCA AGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGCCAGCGGCTGAAC TGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACCTCA GAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCAGCC ACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGTGGG TAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGAGGA GACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGGGGT GGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACC (SEQ ID NO: 218) pARBI-614: GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT 2541 CD5_2_ TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG Exogenous_23 TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGGCTG AACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACC TCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCA GCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGT GGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGA GGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGG GGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACCCAGGAG GGGGACTGGAAGGGGCCAGCACCCATCTGTAGGATGGCAATGGAGGACCT AGTTCTGCCAATCACTGACTTCATCGTCGCCTCTGAACCTCCATTCTCCC ATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAGGAGGCT (SEQ ID NO: 219) pARBI-615: tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt 2541 CD5_3_ aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA Exogenous_24 CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGCCAGC TGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGG GGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTG CCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCA CCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTC TCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGAC CTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCG CCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGC TGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACA TACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGT (SEQ ID NO: 220) pARBI-616: TGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCAG 2541 chr2_1_ AGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGCT Exogenous_106 GTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCAC ATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTCA ATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCAA TGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCCC AGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACAA TTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGTT TGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGATCAGCCATGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGCTTACAT TGTGTGTAGTGAATCAATGTTATTCTGAAGGGCCTCCTGGAAGCAGTAGG GATTGGAGAATGTATGTCTTTTAACATGATCATTCCCATCCTATGGGGGT TGGGCACTCTTAACTCATGTTGCAGATGAGTAAACTGAGGCTTTTGAGAG TTTGAGGGTGCACAGCTTGAGGCAGAGGTGGAATTCCCAGCTTCATCCAA GAAATCACGAATCTCCAATGGCTTGCACACATCCAGGTTTGCTGGATCCT ATTTGTCAAGACCACATGCAGATTAGGAGCCTTCAAACAAATTATTTCCA AGGGAGGGCATCTTTCTCTGTAACCCCTACCCTGGCAATTCTCCATGGCC TCAGGGAGTCCAGCCGGAAGCTCTGCAATGAGTCCTGGGGAACTCTCATC TGGAAAAAGGCGCTCATGACAGGTGGTGCCAACCTTCCACG (SEQ ID NO: 221) pARBI-617: CTACAAGCATGCATCACCAGGCCTGGCTAATTTTTCTATTTTTTGTAGGG 2541 chr2_2_ ACAGGGTTTTGCTGTGTTGCCCAGGCTGGTCTCAATTTCCTGGACACAAG Exogenous_107 CAATCTGCCTGCCTCAGCCTCATAATGTTTTTTTTTAATGTTAAACCCCT TCTTGTGTTGAGAGGCCTGGCTTGTGTGTTTGAGCGCAGCTGCCTACCTT TGCAGCTGTAAATGTCAGGGCTCCAGGAGGGCTGGCTGGGTCTCCCCTCC TCCCCTGTTGGGTGGGTGGGGCCCTGAGCTTATCCAGGCATCCCTAGGTG GATGGATGGGTGGATGGGTAGGCCCTGGCCTTCAGGGAATGCACTGTGTG TGGTCTTCCAGCCCCAGCAAAGTCTCAGGGGGCCCGAGCGGGAAGTCGCC ATCCTCAGGGGGTCCGAGTGGGGAGTCACCATCCTCACGGTCAGCCGTGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCGAATT GAGCTCCCAGGGGCGGAGACTCCATTCCCCCGGGGAACAATCTGATAGCC AGAAATGAGAGCAGTGAGTGACTTGGACGCTGTGTGATTCAGGAGGGTCC CAGTCCCTCAGAGTCGCCTGGACACCAGATTGTATTTACAAAACAGATGG ATGAGGAAATGGAGATTGGGTCTTCAAAAGAATTAACCTCAGATTTTATT TATTTATTTTAAAAATTTTAATTTTTCCCAAGGACCCTTTCCAAGTCAAG AATTGTTTTAAAAAGAAGCCTGGTGAAGGCAAATGCTGTCTGTGGCCGAA GGCACCGTGAGGAGCTGAGGCTGACTTATGTTTCTCCTCTGGGCTATGTG CGCCTCTAAGGAGTTCACACACTTTAACCCCCTTAGGAACCCTACATGAT CATCCTCGTTTCTTAAAGAGGAAGCAGAGCCAGCAAACAAG (SEQ ID NO: 222) pARBI-618: TCTTGATGGATACCCATCCTTCTCTGCTGTTCTCTCTTTCCTCCATCCTC 2541 chr2_3_ AAGCACAGGGAGCTTTTGGCGAGGTTAGCTAACTTCGGGGCAGCTGTGAA Exogenous_108 TTAGATACTGGCTGTAAGTTACCTCCAACATCCAGAGCATTTAAACGCTC GGCTGTCAATGATTGTCATTTTCATTGTTTACATATAGTCACATCCTCAG TTTGTGGGGTGGATGCATTTGATTCAATTCAGATATGCCTTTCAAGCTGG CCCTGCTGAGCTGGGCCTGAAAGGCACATGGCTCATCTCATCTGCATGTG ACAGTCTCTTTGAAGTCCCCAGAAGTGCCTGCTCAGAGTCATGCTCGGGA GGGAAGAGGTAAGGCACAGAATGAGTACAGACTGCCACCCAGCCGCAGGA AAGGTGACTGCACACCAGAGGTTCCTGGTAAGGAGGTGACTCACCCGCGA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCTGTCTCAC CTGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCA GAGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGC TGTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCA CATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTC AATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCA ATGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCC CAGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACA ATTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGT TTGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGA (SEQ ID NO: 223) pARBI-619: TGAGCAAATAGTTCTATCCTTTTTGACACATTTTCCACAGTTTGTATAAT 2541 chr3_1_ TTATTCATAGAATCCTTCTTAGACTACTAATAAATTCCTATGGGACATAG Exogenous_112 TCCTTTTATATGCGGAGGAATCCACCACCATGAAATGTTCACAAGAAATG ACTTTTAAAATTTTATTTGTGGCCATGCTGATTATGAATTTCTGAATTAT GTCTGGGCTGCTCTTTTTCTCGGAATATGCAAAGTGGGATACTGGCATCT CTGTATCTGGAGAGTTACAGCTTCTGAGTTAAAAGATGAATGGGAAGTAG CAGGAGAGGGAGAGATCAGAAATCTCCACTCCCTGAAACACAGACACTTC ACATACCCAGGAGGTAAATTCCTGGCATGAATTGTAACAAGTATACACAG GCATTTGTACATTGTTTGCTTATGTGCTAGATGACATGGCAGTCTATGAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGGCCC CACATCTGCAGGCAGGACATTCAGCCCTGTATCTTGCCACTACCATGAAA TCTGAGGTTCTTTCATTTTTGTTTTTCTATTCTGATGAGATTGAGGTACA CTGACTCACTGGTAAAGAAGACAATTTATTTGTGAACTTGTAGTCACTCC ATTTGACGGCCTCCCTCTACTCACTGAGGCACAGCACGTGTGGAACAGGA AAAAGGCCTCTGGAGAGCTTGTGTTCCACTGGTTTCTTTGACTTTTGCCA ACCAACTTTGCAAATGTTCTCAAAAGGCATTCATTACCTCTGCAGGTGTG AAATAACTCTGCAGTTCAAGGGTTTGTGAAATCACGTGAAACAGCTGAAA GCTGTTCTGGCAAAGCGACCAGAGTCAGAGTTAGCTGTCACCAAGCCACA TCCTGGCTTAAACGATGTTATTTATATCTAACTGCACTCGA (SEQ ID NO: 224) pARBI-620: AGATGCCCATTGTACCACCTACCATTGCTTGACCCCCGCCCATGAGCTGT 2541 chr3_2_ TCCTTCATACTCATAACTAAAATGCCAAATGTGTGACTTGAGTAATTAAC Exogenous_113 TAGAGACCTCCAGAAGGCTTTCCTTCTTATTCTGGGTACATTGATATTTA CTTTAGTATTTGTTTTGCCTTTAAAGTCATGTTCCCTTTTGATTCTTTAA TATCATATCCAAAACGAAGTCCTTTTAACCTATAACAATGCAAATCAAAA GTGCTGTCTTTCAGCTACCTCAAGGATTTAGCAAGCGTTCCTGGAAATCT AACCAACCTTTTAAAAAGTATTTCTATGGGAATGTATTTCTGAGCCCTAA ATTATGGATTTTGAAACTAAAATAGAAGAATACTGTAAGTGCAAAACTTC CAGTAGATAACAGAATTTGCAAAATCTCTAATCTCTTGTATGTGCCCCAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGTAGTACTCT CTATAGGCCATTGGAACAGAACATCTGGCTTAAAATAATCTCAGCACCAA AAACGGTCTAACTATGGTCTCCACAACATAACCCGATGGTTCTCATATTT TAGATGCTTGATGCACAAGTTGAACTGGCTAACAATTCAGACTTCAGGAC TTGACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTG ACTGTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCT TCAGAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATAC TTCGCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTA TTTTATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTC CTCTCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGG (SEQ ID NO: 225) pARBI-621: ACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTGACT 2541 chr3_3_ GTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCTTCA Exogenous_114 GAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATACTTC GCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTATTT TATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTCCTC TCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGGACCTAAACTTGTC TGATTTCCCACACTGCTGCTCCATCAGATTGTTTGCCAGGTTAAGGATTC ATGCCAGGACCTTAAATCCCTCTGAATCGACAGAGCTAACCTAAAGGGCA CCTTGATTTCAGGTTTTGTTCCCAAACCTATGACTGTGGCCTGGCCACGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAATGAAGAC CCGGTTGGTTCTAGCTTCACAATGAGCTCATTGGCATTGTCCCCACAACC ACCACCCCCTCTCCACCTCTGATCATCCACTATCATTTCTATATGGCCTT TGCCAGGCTTGTCCTCATATCAAAGCTTCTGCCCTCTATGTTTAAATGCA TAAGCTTGACAAATGTTTTCATTTGAGAAGGCAAGCTGCCTCCCCGTGCT TGGTCTAATGTGAGCTTGGTAGAGTGACACTGCTGGATTCAGTTTTAGTC ATCAACACTTCCAGCTGATGCTGATCTGAGTAATTGTCCTATTTAGACTC TGACAGGTGAAAGTCATAGATTCAGGAAACGGAGACTCCCCTCACCCTGC TATGAAGGGGAGTTTGAGAGGGTTGGGCAGCTCTTCCCGGCAGTGGCAGG CAGTGTGGGGACACACGTATGGATAAATTGTTAATGCTCTT (SEQ ID NO: 226) pARBI-622: CTGCAGGTGGCAGACTTACTCATTCTCATGCTTCAGCTCCAGGGGTTCCC 2541 chr3: CTGTATGAGTCTTCTCTGCCCGCTCCCACACCCCAGGTAGCATTGCCCCT 1865_ GCTTGCTTTGTGCCCTCACTGTCTCCACATATATACACATCTCTTACAAT Exogenous_109 AATATTAAATACCAGCCAACATTTATATAGTACTTCTTATGTACCAAGTA CTGTTGTCTATCTATCTATCATCTATCTATCTATCTATGTACACACACAC TCATATTATCTTCACAATGCTATGAAATAGGTATTATTGCTGTCCATTTT ACAGATGGGGAAACCAATCTATAATTGGTTTAGTGAGATTTACTGAGCAT ATCTACAGGTATTTGTCCTTGGTTATAGGAAACCAATCTGTCACTGGTTT CCCCTTCTGTAAAATAAGTTAAATAATTTGCTTAAGCTCACTCAGATAGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGTGGTTGA GTCATAATCTGAGCTACTCTCTGGCCCAAACTGCTTATTGTAACCACCAC ATCATATGGCCACTTCAGCACCAGTCACACCTCATTTTACTTGTTGATGT CTCAGTTTTCCCCTCTATTCTGCGGGCTACTTGAGAAGACTTCTGTCTTC TTCCTCTAGGTATCTCTGTGCTTGACTCAGTATCGAGACCATAGGTGTGT GGGTGGGGTTAATCCACACTTGCTGAACACATGTGTCCGTGCCCAATGTC CCTGTGCATAGTGGCTACTTCCCATGGTTCACACGCATCTTCATGGCTCT TGTTTCTTCCATTCACCCATCCCATGTCCCTGGCCCTGTTCTCAGTGCTG AGGATGGAACCTCATTGCTGCTGCTTCCAGCCCTGGCCCTGCCCCTGTTT GGGGCTCAGTGCTTCATCCCGTGGAGCTCAAGGGGTGCTG (SEQ ID NO: 227) pARBI-623: CTTCTCATCCTCACACCCATTCATTTCTTAGTTTCCCATACTCTGACTTC 2541 chr3: TACTACCCCAAGTTCATAAAGACCTCATGAACACAACCTGGAGAACGCCC 1865_ TCAGCCTCATCTCACCTCCCTGCAACACATGGCTCACTTGTCTGCTTCTT Exogenous_110 CCTTCTTAGAGTCCTCTCTCTGGTTGACCTGTCAAAGATGGGATTCTCCT GTTAACGACCCTGACTCCTTTGTCTCCTTCTACAAAGATAATGCACTGAC TTTCCAAATGTACTAACTAGTATGATCATCACTGTCTACTGTTGCATCGA ACCACTACTAACCTCAATAGGGAAGGCACCAGGTTCAAGAGGCCAAAGAA GAGACCCAGAGCCAGCAAATGAGACATGGGGTTTTATGAGGGGCTCACAT AGAGGGGAGAGAGTCCAGTGGCAGTGGGCTGGGCAGGAGAACCACCTTAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACGTGGTCC AGTGGTGGGAGGCTGGAAAAGAGATCTGTCTTGCCTACAGTTCAGTGGTG GCGGGTTGGGCAGGAAAACCACAACTGCCTGCAAACATCATGCAGTTTAC ATAACATTGTCACTTAGCAGCCTCCCCTAACGACCTCCACCTGGCAATCT TCATTTAACCCAAAACTCAAGGCCTCAATCCCCTGTATGGACCATGTTTC ATGGGACAGGCCAGGGGCTCAGAAGTTTATCATAGATAAGGAATGAATCT CCGGGTTGGCCACTCCTGGATTCCCTAGCTTGGAACACACATTCAAGTGT ATCTGCCATTCTGAGTGTATTCTTCAATTATTGCTGTCAGGTGTGTTGAC CCTCTATCTACATAAGTATTTCTCAAACCAGGGCCCTACGATCAGCATCA GCATCACCTGGGGTATATGTGAAAAATGCAGCTCCTGGACC (SEQ ID NO: 228) pARBI-624: GGGCCAAGCAAGCTCTGAGACAAGCTGTCTCACCTCCTCATCTCCTGAGC 2541 chr3: ACAACTCACCCACAGCTCTGCCCTCGCCTCCACCTACATCATGCCTTCCT 1865_ GCATGCCAACTTCCCTCTGAGGTTCCCTTCACCCACTTACAACCACAGCC Exogenous_111 TCCTTCCGGACCTCCCCTACACGATGAACAGTCTGCCAGTTAATATACAT CAAGCTGCCACCATGAAACAGCTCGGAAAGCCCCATTTGTTCTCAATAGC ATTCCAGCTAGAAAGACCATCCACCACCCATGGCCACTGAAGAAGGTCCT CCCCTGAGTGCCAGGCAGTGGGGCTCCTAACTCTGGGCCCCAATTAGCTT AGCTTGGGGGAGCAAAGGACAGGAGCACTGTTCACCCAGTTGGACTAACA GCTCCACACTGTGCCTAATAGGAACCTCCTTCTCACAGGTGGCACCTTTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATCAGG GTCTGTCCTGAGCCACCCTCCCTTGGAGAGATCTGAGCACTGAGAACCAC AGAGCCTGGGACACCAGCACAGGGTTTGAAAAACTCCACTCCCAGTCAGC TGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGT GGATCACAAGGTCAGGAGTTCGAGACAGCTTGACCAGCATGGTAAAACCC CATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGGTGTTGGGCACCTA TAATCCCAGCTACTCGGGAGGCTGAGGCAGGGGAATTGTTTGAACCTGGG AGCTGGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGG GGCTGAGCGAGATTCTGTCTCAAAAAAATGGGAAAAACATCATTCCCATG TGTGTCCTGGTTGCTTGTCTCTTTCAAAGTACTGCATACT (SEQ ID NO: 229) pARBI-625: CCACATCATGGACCAGAAGCCACTTGGTCTGGTTGTGAGGATGACGGAAC 2541 chr8_1_ CTTGCCCGAGGAAATGGGCAATGAACAGGAGCCTGTTTGTTTCTCCTTCC Exogenous_115 AGCTCCTGACCTGTCTAGCTCCTGACCCTCTCAGTGTCATTCTTGCTCAC CCCTGGCCCTGCTCCCTGGATATGCAGACAGGATGGGCTTCTTCCCTTTA GACCTTCACTTTGCTCTTTTGGACTCCTCTTCTGGCCTTGCCTTCCCCTG GTGTCATCTGCTGGCTCCCTGCCTGATACTGCCACACTGGTCATGCTGGC CTCCTGGCCTTTGGTGACACCGCATCAGCAGGCTCCTGCTTCCCTGTCAA GGGATACAAGCCAGCACCGGTCTTTCGCCACAAGGTATGTGTGTAAAGAT TGCTTCCTGTACTTGGTGTCCACAGGATTTTAAAGAACTCCTGGCCCACT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCGGAACTCT ACGCTTGAAACAGAAACATCTTCTCAAAACACCTCTGGTATTGGCCCATT TCTCTATTACTGTTTCTTGTGGTTTCATACTGAGGTTTTTGGTGCATTGC AATTGCCCTGGAGTTTATTTTTAGTAATAAAGACAGAGTTCAATTAATGT CAAAACATGAGGGTAATTGCAGAGGAAGGATTAGTAAGTCTAGGGGAAAA TGTGCCCAACTTTTTTTCTTCTGATAACATCTTTCACTGATCATACACCG TCACACCCACAGACACGGAGCTTCCTCCGTGATGTCTGCAATGCACTAGG CCCAGTCGGGGAGCAGTGGCTGCGCCACCACCTGAAAACGAAAGCATTTC TGAGTCTCTTTCAGTCCAGCTCATCTAGCAGCCAGCCACACAGGTGACCA CCCACCGTAGCTGTCACTATGGGTGATGATTATCATTATGG (SEQ ID NO: 230) pARBI-626: AGGATCTTTCTCTCTACAGTGCCTCTTGTGGGACGGGTTCTGCTGATGGG 2541 chr8_2_ GGCTGTGTTTGGGATCTCGCCTGGAAACACGATCTCTCCAACTTTCCCTG Exogenous_116 GGAGCAGAGCCTTGGGTCTCACTGAACCCACCTCCCCAGCACCTTGTGTG GTGACTGGCAGGAGGTAGCCATTCCCTCCTGTCCTCTCTGCCCTTGTCCA CTTTCCTGTTATGAGTCAGTTGCTGAGATAGGCTATGAGGAGTTAACAGA GTGGATAAAAAAGAGCTTTGTCCTTCTTTAAAGCCTTCAAAATATACAGA TGTATTAGTCAGGGCTTTCCAGAGAAACAGGACCAATAGAACATGAAGAT AGATGCGTATCCATGTCTATATCAATATCTACCTTGATATTTATATCTAT ATCTAGGAGATTTATTTATTATAAGGTATTGGCTCATGCAATTATGGACC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGAGGGGT CCTGTGATTTGCCACCTGCAGGCTGGAGACCTAGGAAACAGCTGTCGTGT CACAAAGGGCAGAGGGCTGGAGAACCTGTAGTGTAGATTCCAGTCCAGAT TCGAAGGCCTGAGGACCAGGAATGCCAAGGGCAGGAGAAGATCGATGTCC CAGAACAAGCAATCAGGCAGAGATGAAATTCAACCTTCCTGTGCCTTTCT GTTCTATTCAGGCCTTCAGTGGGTTGAATGAGGCCCAACCCACATTGAAG AGGACCATCTGCTTTACTCAGTCTCCTGGTTGAAGTGATAATCTCATCTG GACATACTCAGAAATGCTGTTTAACCAGCTCTCTGGAAATCCTGTGGCCC AGTCAAGTTGACACACAAAATTAACCATCACACTGCAGAGACACAGTCTA TCCCAATACCTGTATTTACTGGGTAACGTGCATCTCAGCTC (SEQ ID NO: 231) pARBI-627: TAATAATGACTCTGCTGGTAATTTGTGTCCTTCTGCTTGGAACTGTTTCC 2541 chr8_3_ TTTTTAGTTTGGTCACCCTCCCAGAGCTGGTTTCAATGGGGGCATACCCA Exogenous_117 TTATGGGATGCAGGGCATCCTGCATCCTGAGGAATTTTTTTTCCTCCAAA AATGAAACCTTGAAATGAGGACATTGTCCTGTCCACGGACTGCACAACAA CACTGAGCCTCAAGGACTCATACTGGCATTTTTCTTCTTTTGCAGAGTGT GGGCACCCTGGCTTCAAGCTCACGAGAAACCAGGTCGGGATTTAAACAAT GTTGGGTTAAAGCAAAGTTTCATAAAGACAGAATCAAGAAAAAAAGAAAG AGAAACCAATCTAAGTGCCATCCTCCCTGAGTTGCATCTTACCTGAGTCT TCAGCCGCCGCCCCCTGCTGCTGTGGGAGGAAACGGGAAAGTGACTGGCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatATGGGGACA GGGGTCGGGGGTGTGAGGGTTAGTGGTAGCAGGGAGGTAGCACTTCTGTG AAGCCGGAAAGGAGACCTGAACCTGGCTCTCTGCTTTGCTGCTTGCCAGC CCTCTGGCTGGGAAGAAGGCTCTTGGCTCTTGTGAGCCTCGGTTTCCTCT GCAGAGTGGCCTGTTCTGAGGACAGGCTGACATTGCTGTCCATCAGTCTT CCAGGACCCTGAGGATTTCAGCTCTACCCATGGGCACTGAACTGGAACAT TCACTGGTCATTTGCTTTCGTTTTTTTTTTTTGTTTGTTTGTTTTTTGAT ACAGAGTTTCACTCTTGTTGCCTAGGGTGGAGTACAATGGCGTGATCTCA GCTCACCACAAGCTCTGCCTCCCGGGGTCAAGCGATTCTCCCCAGTAGCT GAGATTACAGGCATGCGCCACCACGTCCGGCTAATTTTGTA (SEQ ID NO: 232) pARBI-628: AAGTCAACAACAGGCTCCAGAAAAAAATGGAAATATAAATGGTCCCCAAT 2541 chr9_1_ TTGGCATTTTGGAATTTGAGGCTTATATAGTATGAGCAAAATAAACTCCT Exogenous_118 CCTGCTTCTATGAATTCTTTGCACTTTTTCTCTATAATTCCTTATCAAGC AATGGGTTTGTCTGTTAACCAAGACTATACATAAAATGTATTCCCGTAGT TCCTTTTATTACATTTTTTCTTTGTTGTTACTAGTGGAGAAGCTAACAAG AGCAGAATTTCCTGCCCAACCGTAGCAAATACAGAAAATCAAAAAGAGAA GCTTTGATACAGCCAGTGTAGATACAGCTAGGACGTCATGAATCAGAGCT CCCACACACGATGATAATGGAAACATCTTATCCATATCTGATTTGCTCAC ATATAGTTATTTAGACAACAAATTTTACATTCCTGGATAGGGAGCCTCCG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTC AATCTCATAGTCCAGGTAGGTGTAAAATGACTGCCAAGCCAGCAGACATA AATCTGTATTATCTCATTTTCATCACAGTCTCTGCATTGGGAAAAAAATG TGAGTGAAAAGACATTTTCTCCCACCTTGTTAAGTACACAATTACATAGT TTAAAGAAGATAAGAATTTCAAATTGTTAGAATGATATCATTATTCAAAT GATTCCCTGAGAACTTCAAGTATTCCCCTTCCCCCAAATGTAGGCAGGGC AAAATAGAACCAGTAGGAATGAAAAATGTTAATTGTTTCAGGTTCTGTAA TTTTGGGTTTAATGACTCAGGCTATGTGCTACTGAGTAAAATACTCATCT GGAGAAAAAGACTGTTGCATGACATATTTCTGATTAAGGACAATTTAAAC TAATTCTAAGAAAACTCTTACATACTGCACATGCCATAAA (SEQ ID NO: 233) pARBI-629: GATTAGGTCTGGAATAAGATTGCACCATGACTAAAATGACTTCTTTAGCC 2541 chr9_2_ AATGACATTCCTGAAGATTGGATCAGAGTAAAGTTAAACTAACCTACTCA Exogenous_119 AGGAAGACTTTCCTAAATCAGCCCCTTTGCTGTATAATTTAGTATGGAGA GCTGATTGTGGGTTTTTCTTGTTTCATTGTTTAATACATAGAGGTTTCAC ATTTCATTTTGAAACAGAAAGAGGGACTGGAAGAGATAAGTTAGTATGAG TGAGGAAAAGATTAGAAGGTAGAGATAGGATCGCAATGCTGTTATCACCT TTGCTTTATTGATAATCTCAGGAAGGACTAGACTGCTAAGAAAGAGGAGC CCAGATTGGAATAAAAGAGACGATGCCAGGATCAGCCTGTGAGAGGATGT CTCACTTAGTACACCTCAAGGATCATGTCAGCTGAGCATCTATACCCCGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCG AGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGC GAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCAC CGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACG GCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTTC TTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTT CAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCG ACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGAC GGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGT CTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGA TCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAG CAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTA CCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATC ACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATG GACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaata aagcaatagcatcacaaatttcacaaataaagcatttttttcactgcatt ctagttgtggtttgtccaaactcatcaatgtatcttatGTGATGAATATT GCATACAGACTCTGCCTTCAAGTCATCCCCCATTCGACAAGCATTTATTT AAGGTTCTTACATTCCAGGACTTGTACTAGATGCTAGAAACAAACAGATA AGGAAAACGTAGGAAAATGCTTCTCTCAGGAAGCAATATTGTATATGAGT GGTGAAGAGCTTCAAATCTGGGGCCAAACTGCTGGGTTTGAAATTTGGCT TGGCCACCTACTGGCTGTGAAATCTTGGGCAACTTTCTTAATCACTCTGT GCCTCAGTTTCTTCATCTGTAAAATGAAATAGCCATAGTACTTATTACAA ATAGGTAATAATTAGTGAGAATTAATTTGAGTCAATACATAAAAATGACT CAGAATAAAAGACCAGCTAAGAATATATACACACATACTTAGCTACTTAT AATCTAGTAGGAAAGATGGGTATGTTATCAGAGGACTT (SEQ ID NO: 234) pARBI-630: CAGATAAAAAAAGCTGAAGCTCAGGGATATTGTCATTTACCCATGAGCTC 2541 chr9_3_ ACAGGCAGGAAGTGGTGAAACTATCATTAAACTACGGTTGGCCTTGTTCT Exogenous_120 TTTGTGGTTTCATTTCACTAAGCCTCTGACACCCTGACCTCAACTTCCTT CTGTAGATATGTCACCTGGCCTCCTTCAGTCTAAGACACTACACACTGGC CACACACTTTGTCATCCTCATAGACTGACAACCTGCTCTCACATACCCTG CTTTCTTACTGTGTAGGCTCTCTTTTCTTGCTCAGAATGTCCTTCCCCAC TTCTTCATGTGCCAACTCCTAGTCATCCTACAAGAACCACATTCACTTTA AGTTTCTTTTGAAGCCTTTTCAGTGTCCCATACCCTGATCCCATTACCTC TTCTATGTATGCAGGGCTTGCTTCATGCTTGTGTAACCCAAGGGCCCTGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTA ACACATTTTAAAATTCTTAACAATTTATGAAAAAGGAAACCCATATGTTC ATTCTGCCCTGGACCCTGCAAATTATGCAGCCAATCCTGTGTGTGTTTTT TCATGTTGCGTAGACTCTATTACAGTCAGTAACATATTGAGAAAGAGTGT GTGTCTCCTCTGATAGTCTATGAGCTCCTTGAAGCAAGAGGCTTGTCTTA GTCATTGCTGTATCCTCACACCAGACTCTACGGGATGCTCAGGATTCACC TGTTGATCTGTGAGGAAGCCCAAGGCTCAGTTAATGCCCCCCACCCTCCT TCCATAACAGTCTCCTGATTAGGAAACAGTGCTTGACCTCTAGACAATCT GAGTATCCACTCCAGGAAGTGGAACATTGCCTTCCCAATGTTGAAACTGT TAGCACTCAATCATGTTTCAGGAACATATAGAAGGTATGT (SEQ ID NO: 235) pARBI-631: TGGACCTTATGCAGGGTAATAAAAACCAACACGTGGGGCCTGTGCTGTAA 2541 chr10_1_ GGTGGCAGAGGGCGATGACTCACCCCACTCATGCAGGTTGAGTCATTTCA Exogenous_90 AGGCAGAGTTGTGCCAGTTCAGTACCCAGTAATATTTTCCAGTCGACGAG TATCAGTGAACAGGAGATAACCAGTCATTTCTAGATTCTGCTCAGAGTCC CAGCTTAGAGGCTCCACCAGCTCAAAGAGACGGGATGGCAAAACAGCCAC CTTAATTTCCAGATCATCTGCCAGCTCATCTGCCAGCTGACACACAGCCC ATGGCTCCACTATTGCCAGTGCTGTAGCTGCACCAGACCAATCTGGTTCA ACTTTTATGTAACAAAGTTGTGATTTGTTTTTCAGTTGCCCGGGACTCCC AGGTTGAAGATCATGAGCATGCCCTGATGAGCCAAGGCATGCAACCACAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAACCTA AGTGCTTGGACTGAGGAGTGGGGACTGAAATAAGAAGCGGACACTGCAGG GCAGGATCAGGATCCAATCAGATCGAGCCCTGGCATCACCTCATGGCAGG ATCTAGTCAGATCGTGGCTTTTGACATCACTTCATTGTGAAATCCAATCA GATCACACCTTATTACCCTATCCTTATAAAACCGGACCTAGCCCCCAGCT CGAGGAGGCACTGCTTTGGGAGTTATCCCAGGTGTTCTTGTTACTAGTTG CAAGGAATAAAATCCTCTTGCTAAATCCTCCTTGGTTGTGCAGATGTTGG CATGGATGTGGAGAGAAGGGAACACTTACGCTTTGTTGGTGAGGATGTAA ATTAGCTCAACTCTGTGATAAACAGTATGGAGAGTTTTCAAAGAACTAAA AATAGAACTTCTACTCAACCCAGCAATCCTATGAGTGCATG (SEQ ID NO: 236) pARBI-632: ACATCTAATCCCACACCATGACTAATAAACATGGCATGCTGCAATGGGCA 2541 chr10_2_ TTAATTTATGGGTAACAGAAGCAGATCCAAGCCTTTTAGCTAATTAAATA Exogenous_88 AAAATGCACCATACAGCAACCATCCTGCCTGCTTGGGTGTAAAATAGAGA GGAGAAAGATGGCATGCTGGTCATTGAGAGATAATTACCTGCAATTTCAG AGCTGGAATCTAGTGACAACATAAGAAAAATAATAACCTCTCTGGCTGTT AGGATTCTCAGTTCTAGCTGCGAGCAAGGAGCAAAGGCACCCACAGACTT GCCAAACCTATGTCAGGAATGACGAATAGAAGGCAGAAATCCACATCCCC AGGTGGTAAAATTGTTATCCACCTTCGTCACCTCTTTCCTAATGGAGGAA GTGAGGACAGGCAGCCTTGGAGTCCTACTTGAATGAGGCCTGGACCTTAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGCAGGGTAA TAAAAACCAACACGTGGGGCCTGTGCTGTAAGGTGGCAGAGGGCGATGAC TCACCCCACTCATGCAGGTTGAGTCATTTCAAGGCAGAGTTGTGCCAGTT CAGTACCCAGTAATATTTTCCAGTCGACGAGTATCAGTGAACAGGAGATA ACCAGTCATTTCTAGATTCTGCTCAGAGTCCCAGCTTAGAGGCTCCACCA GCTCAAAGAGACGGGATGGCAAAACAGCCACCTTAATTTCCAGATCATCT GCCAGCTCATCTGCCAGCTGACACACAGCCCATGGCTCCACTATTGCCAG TGCTGTAGCTGCACCAGACCAATCTGGTTCAACTTTTATGTAACAAAGTT GTGATTTGTTTTTCAGTTGCCCGGGACTCCCAGGTTGAAGATCATGAGCA TGCCCTGATGAGCCAAGGCATGCAACCACAGGGGAACCTAA (SEQ ID NO: 237) pARBI-633: TGAGGTCTTGGTATGTTGCCCAGGATGGTCTCAAACTCCTGGGCTCAAGC 2541 chr10_3_ AATCCTCCTGCCTCCACCTCCCAAAGCGCTGAGATTATAGGCATGAGACA Exogenous_89 CAGAGCCCAGCCACTGTCCGCATTTCTTTCCTGGCTTCCTTACTGGGTTC TCTACTTTCACTCTTGCCTTCTTCCTCTCTTCCACCAGCATAAGTTTTAG AAACTGCACTTCTGATCATGCTGCTCTGCTGCTTAAAATCCTTCATGCAG ATCATGTAAGACCTTCCTGATCCAGTGCTGCCTTGCCCTCTAGAACCCAG GGTGCCTTTCTCCCCTCTGCAGTTCTACTGCGCCACCTGCAGTTTCTCTC TCCTGTGTTCATGTGTCTACTCCCTCTGAATGGTAGGCTCACACCCTCCA CCTGGCCAACTCTTACTAAATCTTGGGCTTCAACTCAAGGATCACCTTCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTCACTC CACCAGGCTGGGCTGTGTGTCCTGCCCAGTTCCTATAGTGCCCTAACTCA CTTTTTTAAAAAAATACTTTAAGTTCTGGGGTACATGTGCAGAACATGCA GGTTTGTTACATAGGTATACACTTGCCATGGTGGTTTGCTGAAGCCATCA ATGTCATCTACATTAGGCATTTCTCCTAATGCTGTCCCTCCCCTAGCCTC CCACCCCCCAACAGGCCCCAGTGTGTGATGTTCCCCTTCCTGTGTCCATG TGTTCTCGTTGTTCAGCTTCCACTTATGAGTGAGAACATGCGGTGTTTGG TTTTCTGTTCCTGTGTTAGTTTGCTGAGAATGATGCTTTCCAGCTTCATC CATGTCCCTGCAAAGGACATGAACTCATTCTTTTTTATGGCTGTCCATTA TTCCATGGTGTATGTGTGCCACATTTTATTTATCCAGTCT (SEQ ID NO: 238) pARBI-634: CCTTCCACCCCCTTCCTTAATAGTTTTCCTCCTCCGCCTCCTGCACGGCC 2541 chr10_1_ TCCGCCTCCGCCTGACCGTCCTCGGAAACCTCCCAGCCGCAGCCCGGCCC Exogenous_92 TCCCCAGCGGCCTGAGTGGCCTCCTCCCGCGGCGCCCCCCAGCTCCGCAC CTCCCCAGCCCCGCCCGAGGCGCGCCCAGCGAGCGTGACCCCGACCCAGG GCCACGGCTGCGCCCGTAGGATCGCGGGCGCGCGGGTCTCCATGAGGGAC TGGGAGAGATGCGTCACCCGCTAATCCCTCAACTGGGTCGCACCCGGTCT GCCTTGGTTGGTCCCTTCTGATGGCGGAGGCGGGACCTCGACTTGGTGGC CAATGAGGAGCCTCGTGGGGGTGCTCTCGGCTGCCATGGCAACGGAGGGG CCGCCCGCTTCCCCGCGGGGCGAGGCCGGCTCTCCCAGGACTGGCCACAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGCAGTCAC GCGCTGTGGCCCCAGTCCTGTTAGCATGAGGTGGGGGTCAGAAGTTGAGG AACAACTCGGACCTAAAGCCTTGACAATTGCCAACAGTGTAGACAAGTCC CAGCATGCCCAAAATTTATAAGAGAAGGCTGCCTGGAAGAGGGACACGAT GAGGAGGGTCTGCTGAAACGGACAAAGAAACCCAGTTCAGTGCAGTGGAG TGGACATGGCACGGGCAGGGCACGGAGTGGGGTCGGTGCTTAGTAAGCGG ATTAGGGTTTCCAAGCCAAGACCCACCCAGGGCAGGATGGGGAACCAAGG TGAGCAGGTGCGCTGAATTGTGGGTCTCACACTGTCCTTCAGTGTCCCGC AGGAAGAGAGAGCTAAGGATCACCAGGGTCATTCCCCTGCCTCAGGCAGC CTGCACTCCACCTTAGGTACAGTCATGTCCGGTCTTCAGCA (SEQ ID NO: 239) pARBI-635: TGATCCTCCCACCTCAGTCTCCCAAAGAGCTGGGATTACAGGCATAAGCC 2541 chr10_2_ ACCTTGCCCCGCCAGTTTTTAGCCTGTCAGCTCTTTGAGGGACACTTGTT Exogenous_91 ATGGTCATACCCACAGCTTTGACCCTTACCAGGTGGTCAGGTGGATGAAT GAATGAGTAGAAAGAAGGAAGAGAAGGCAGGAGGGAGAAGAGGAAGAATG AAGGAAGGGTTGAGTTTGTTCTGGAAGCTCCCAGCTTCCATCCGCACCAC ACTCTCCCTCTGTCCCCAGGACACCAGGGAACTGACTCAAGGCTCTCCTC TTACCAGGTGCTGTGTGGGGTCCAGGGAGAAGAGCCCATTTGAAATGGGG CACTGGTCTAAACTCTGGACCTGCTGCTCACTATTGACTGAACTTAGCCA CTTAAATATTCTCCTCTATAAAATGGGAGTGACCATAGCAACTACCTCGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATTGTA GGGAGACCCAAAAAATGTATATGAATACATTTGTCAACTAAAGAGTGTTA GGGATTATCTCAGTGGAGGGATAGGCAGTGCAGGCTCTGGAACCAGACTT CTTGTGTTCACATCCCTGCTCCACTGCTTGGAGACCTTTGGCAAGGTCCT TAACTCCTCTGGACCTCAGTTTTCTCATCTGTAAAACAGGGATTATACTA GTTCCTACCTCACAGAGTTGTGAAGATTAAATGAGATAATGCATGAAAGG CTTTTCAATAAGAGCAGGGCACACATTAGGCATGATGTCCATGATCAAGT GCCTAATATGTGCCTGCTCTCAGGAAGGATGCTGTGAACTACTTCACACT AAAGTGTAAATGAATGATAAGATCTACTATGCTCCACTCATGCCTGTAAT CCTAGCACTTTGGGAGGCCGAAGCAAGTGGATCACCTGAGG (SEQ ID NO: 240) pARBI-636: GGTGAGGTCACCCTGGGTACCTGGAGTTACTCAGAGTGACACTAGTACAC 2541 chr10_3_ GCCTGGCAGGAGTGATGGATGAGCTAGGCTCCAGGAAAGCAGGTGGGGCT Exogenous_93 GGAAACCACCCAAGACAAGGAAATTGTTGGGTTTGAAATTCCAGGTAAGC AGAGTATGGCCTGAGAGCAGCGGCAGAGGCTGAAAGTGGGCTTGGTCTCG GTATTTTTGAGGCTGAGGTAGCTCCAACTCTCTCCCTCTGAGTCAGCACC CCACTTAAGACAGAAATACTGAGATCTGCGACCCCAGCCTCCCCCACAGC AACTCCACAGTCCCCAAACCTTTGCTCCGCTGGGTCCTCCCAAGTATGGT AGCTGACACAGCCCTGAGCAGCCCACTGTCCTCTGCCCTGCCAAGTCTTC TCACTCTTGTCACTTTGTCCTACATCATTTCTTTGTCTGGCACCCCTCCT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAGAATTGGT GCCCCAGAGGTGGGAAAAACCTACCCTGCTCACTGCTCTATCTCCTGGGC TTAGCTCAGACTCTGGCATACGTGAGTGCTTAGTAGAAACTTGATGGGGT ATTAAAATTGAGACCTGGGTGGGTTCTCACATTAAATTTCTAACACTCCT TAGGTGGCTTGGGCCCACCCCTCTGAGCCCTGTTTCCACATCTGTAAAGT AGCAAACCATCGCCATGAAGAACAGGGAAGAACCAGGTCAGCAGGCAGGG CGGATGAAGCATCCAGCCAGTTCTAGGAAGTTTCCGATGGCTAATCCTTC AGATGCAGCTTGTAAGCAGGTCAAATACAGAATAGGAAACTGAGGCGCAA CGAAGTCATGCTTAGAAGTCTGTCCAGGGAGACCAGTCAAGGCCTCCCCC ACACCCTGCAAGCCCTTCTAGGAGCTCTGGTTAAGTCACTC (SEQ ID NO: 241) pARBI-637: ATCTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACT 2541 chr11_1_ GTAAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAG Exogenous_99 AATGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTTTTAAATG AGCCAAGACTAGAGGGGAAACTATCACCTAAAATCAGTTTGGAAAACAAG ACCTAAAAAGGGAAGGGGATGGGGATTGTGGGGAGAGAGTGGGCGAGGTG CCTTTACTACATGTGTGATCTGAAAACCCTGCTTGGTTCTGAGCTGCGTC TATTGAATTGGTAAAGTAATACCAATGGCTTTTTATCATTTCCTTCTTCC CTTTAAGTTTCACTTGAAATTTTAAAAATCATGGTTATTTTTATCGTTGG GATCTTTCTGTCTTCTGGGTTCCATTTTTTAAATGTTTAAAAATATGTTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACATGGTAG TTCAGTTCTTAACCAATGACTTGGGGATGATGCAAACAATTACTGTCGTT GGGATTTAGAGTGTATTAGTCACGCATGTATGGGGAAGTAGTCTCGGGTA TGCTGTTGTGAAATTGAAACTGTAAAAGTAGATGGTTGAAAGTACTGGTA TGTTGCTCTGTATGGTAAGAACTAATTCTGTTACGTCATGTACATAATTA CTAATCACTTTTCTTCCCCTTTACAGCACAAATAAAGTTTGAGTTCTAAA CTCATTAGAATTGTTGTATTGCTATGTTACATTTCTCGACCCCTATCACA TTGCCTTCATAACGACTTTGGATGTATCTTCATATTGTAGATTTAGGTCT AGATTTGCTAGCTCCAAGTAATTAAGGCCATGTAGGAGAGCATGGTAACC ACAGATAGAACTGGTATTATCCCAAGTGGTCTGCAGACTGC (SEQ ID NO: 242) pARBI-638: TTACAGCACAAATAAAGTTTGAGTTCTAAACTCATTAGAATTGTTGTATT 2541 chr11_2_ GCTATGTTACATTTCTCGACCCCTATCACATTGCCTTCATAACGACTTTG Exogenous_97 GATGTATCTTCATATTGTAGATTTAGGTCTAGATTTGCTAGCTCCAAGTA ATTAAGGCCATGTAGGAGAGCATGGTAACCACAGATAGAACTGGTATTAT CCCAAGTGGTCTGCAGACTGCTGAGTGGGGATGGGATCTGCTCTCTGTTG AGAGTTGGTAATCATTGGTTTGAAATGTGATGAAACCACTCAAGCCAATG AAGGTGGGTGTGTAGGTGGGGAGTACTTTGCCATAATATTTTAAAACATT ACCTGGTTAGAGTTCTAAGTGGTACTTATTTTTGTTTGGTTAGGGGAAAG CCTGAATAAAAACAGAAATGGACACATAATATGCATATTCCATAGTCTTT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAGGCTG GAATGTGCCTGGGATTTGGGTCTAAGTGTATGCGTAATTCTTACCTCACT AAAGAATTTGCCTTGTTTTTTTCCTTTTGGTGAGTGACTAAAACGTCTGG GCTTCCCTGTGTGCGTGCTACAGTAAGCAAGCAGAGGCTGTGCAAAGGTG TGAGCAGGATCACGTGGAATCTGGAGGATACATCTTGGCTTGCAAACTGC CTCTGTCTCCTGGGTGGGACTGTTCTGTCCTTGCACTGCTGTTCTGTGTT ACCTCTTGGGGTGTAAGGTTTTGCTTACAGGAGACAAACTTTGGGCGTAG AATGGAAGCCACTGCCAGCCTCTGTGCTGAGAAGGAAGGTGCTTGTTTCA AAGGGAGCAGCAAGGGAGGCTTGTTCTACTCACCTGGGCCTGTTTGCCTG AGAAGGGGAGATAAGGGCTGAACTGGGACTAGCCAGGGGGA (SEQ ID NO: 243) pARBI-639: TGGGGCTTTGGGGAATTTAGTGCGTGGGTGAGCCAAGAAAATACTAATTA 2541 chr11_3_ ATAATAGTAAGTTGTTAGTGTTGGTTAAGTTGTTGCTTGGAAGTGAGAAG Exogenous_98 TTGCTTAGAAACTTTCCAAAGTGCTTAGAACTTTAAGTGCAAACAGACAA ACTAACAAACAAAAATTGTTTTGCTTTGCTACAAGGTGGGGAAGACTGAA GAAGTGTTAACTGAAAACAGGTGACACAGAGTCACCAGTTTTCCGAGAAC CAAAGGGAGGGGTGTGTGATGCCATCTCACAGGCAGGGGAAATGTCTTTA CCAGCTTCCTCCTGGTGGCCAAGACAGCCTGTTTCAGAGGGTTGTTTTGT TTGGGGTGTGGGTGTTATCAAGTGAATTAGTCACTTGAAAGATGGGCGTC AGACTTGCATACGCAGCAGATCAGCATCCTTCGCTGCCCCTTAGCAACTT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAGGTGGTTG ATTTGAAACTGTGAAGGTGTGATTTTTTCAGGAGCTGGAAGTCTTAGAAA AGCCTTGTAAATGCCTATATTGTGGGCTTTTAACGTATTTAAGGGACCAC TTAAGACGAGATTAGATGGGCTCTTCTGGATTTGTTCCTCATTTGTCACA GGTGTCTTGTGATTGAAAATCATGAGCGAAGTGAAATTGCATTGAATTTC AAGGGAATTTAGTATGTAAATCGTGCCTTAGAAACACATCTGTTGTCTTT TCTGTGTTTGGTCGATATTAATAATGGCAAAATTTTTGCCTATCTAGTAT CTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACTGT AAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAGAA TGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTT (SEQ ID NO: 244) pARBI-640: CGACCAACCCATCAAACTCCCCGCCCCCAGCACTTTTATTTCTCCTCTTT 2541 chr11_1_ AGGAAGTACACTTCAGTATCTTTGGCACAGTGCATGAGCACGACTAAAGT Exogenous_94 AAAACATCGCAGAAAACATAGCTTTAGTCTACCCTTCGTGTCCTAAAAGG AAAACCAGTAGCTTCCCAGGCCACCGGAAGGGCAACACATGTCCTCTGCA GTTTCTGCACACGGGAAGGTAAAGACAGAGAGAGGACCTACTCCTCAACA CAGAAACATTTCAAAATCTTTCCTCGCCTGCAACCCAAGCTGAAGTCATT CTCCCCAGAAATAACAAAAGTTGGAAGAGAAGCCGGAGACAGGATAGGTG CAGGAAGCCCACACTTTGAGGGCAGCACTCAGACACCCTCTCCTGTGTGC AGGACGTGCCGAATGTTCAGGTGCAATGAGAATGAGCCATGCTTGGCTTA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCGAGGGCAA TCTGGCCCATCAAGTGGCCTTCGCCTCTGGGAGTAACAAAAATGCACTTC AAAATAGCTTCTGTAATCAAGCTGCATGGGTGGAGTACTCCCCAGCTGAC TCCAGGAAGTTCTCTATCCAAAGCTATTCATTAGGCCAGAGCTGTGCAAA TAATTAGTCACCCACTTGCTCCATAACCCTCCATGACAGCCCAGGCATTG AGTCCAGGTGGGACCATCAAGCCATGCTCTGGTGGCTCATGCATTATCAT AGAAATGGGAGGCTTTATTTATTTTACTAAAAAGAACAAAAACAACAGAC TGCTGTCCTTTAGACAATAGGATCACGTCATCTGAGCCCTCTGTGCCCCA GGTGACAAGCCCAGCCCCAAGTTCTCTTTCCTCAGCCTCCCCACACATGT TCTGGAGGAGATGGGCCCAGCAGGCTGCTCTGAGGCCTGGC (SEQ ID NO: 245) pARBI-641: TCACAGAATCTTGTTTGAGCTAACAACCAGTTATTCTACCCAAAGTAAAG 2541 chr11_2_ AGTAACTTAAATTTTCCCATTGTTCTTCCAGGCTGGAAGATGTAAGAAAC Exogenous_96 ACACACAGTATAGTGTAGGTTTCCTCCATAGTTAAGTACCCCAGAGCTAG GCTGAAATCCAGTGTTGGATTGTTTCCAACTTATAGTAGGGAACCGCCAA TGACATGAAAGAGCATTACCTTACCGGACTGATTCATATTCTACTTCCAG TCATAGTACAAATGATCACATGTCCACACCCACATGTGCTCTGATAAGTA GTCAATTGAGAGGAGTGAGTCAGGGAGCCGTAACTTTGCAGCCAACCTGC CAAGAAGAACTGATGCTTTTAGAAATTCAGCAGCTTTCATTGGCATAGAA GTTTCAGCCTTATAGGCCCAGGGTTTCTCTGAGGCAGAGGCAAACCCTGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGTTATGTT GTTATCTCAGGATTCTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTT GCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCC TCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACT ACAGGCGCCCGCCACCACGCCTTTCTAAATTTTGTATTTTTAGTAGAGAC GGGATTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGAT CCGCCGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGC GCCCAGCCTATCTCAGGATTCTTAATGTAAAAACAGTTCAGTATGGAAAG CGTACTTATGACAGAGCTGTTGCAGAATGTGAAATCACCCATGTGCCTAA GTGTCTCCCTACTACCTGGAACACTAGACCACATGCAGCAG (SEQ ID NO: 246) pARBI-642: CAGCCCTGAACTCAGCCTTCACGGCCCTCCCTAAACACATGGGCCAGCCA 2541 chr11_3_ CAGGGAAGAAAAAAATGCCCTGTAGCACAGGAATCTAAAACATTGCTGTT Exogenous_95 GTTCTAGTTAATAAAAGGACTTAGAGATTGAAAAGAAGTACCATCTGTAT GGCTGGCAACAGACAGCATGATTTTGATGACTGACTCTGGGGAGATCTGA GAAAACAGTACATAATATGTCCTTACCTCTGCTCCATCATTCATGACCCA AGCTCCTGCCCTGTCTTCTCAGGAAGATTCTTACAGTAACTCCAGTTTGG AATTCCCCTTTCATATTTGAAATAACAACAGTAATAGTGACCACTAATGC TTACCGAGTGTCCACTCTGTGCCAAGCATCGTGTTTTTATCATCTTTTTT GTTAGGCACTGTACATGGATTAATACAATTACAACCCACCACAACCCCAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGAGATAAGT ACTTGTACTATCCTCATTTTATGGGTGATGATACAAGAAACAGAAAGGTT CAGCAACATGCCTAAAGCCACACAGCTACTATGAGGCAAAGTCTAGGTTT GAACTCAGAAATTCTGACTTCAGACTCACTTATCTTATTATACTTCACTT AGTATCTCCCATTAATTAATTCATTCATTCTTCCTTTTATTTGTTAATTC ACCAAATATTCTGGGAAGCTACTTGTCTAGACACTGTATGAAAAATGAGA ATGGATACAAAGCAACCTCAGACATGAACTCAAGGTCCTTACAAGCTTAA ACGTATATGATACATTTCCAAATAGCAATACTATGAGGACAGCTGATACT CACAACATAAGTCTTGGTGGTCACAGGAGATCTATCATAGGATTTCACGA AGAACCTGACACTGAAAACCAGAACTTGAGGGAAATAAAAC (SEQ ID NO: 247) pARBI-643: GTGTCCATCCTGCATGTCTCAAGTCACAATCCTCCAGATATTCAACCAAA 2541 chr15_1_ GTGCTTGATTCTGTTGGCACAAGGACCATGAAATCTTCAGTAGCTAAGGA Exogenous_100 GACTCTTTGACAAATAGATTTATTGCATATGATGTAAAAGGGTCTCATTC AGAGAACTACACATTTACTACACATTTACTAGCTGTTAGATGTGAGAAAT TGAAGCTTTGAGAATTGTCATTTTGTAAGCACGCTGTAATAATTGTGTTC TCTACAAAAATGGAGAAATACTTAATCTTTGCAGGTTTTTATTAGCTTCG AAAAAGGGAATACAAATATTTTGATACCTGACTTTATTTTAAAGATACTG GCAAGCAAGGAAAGATACTCAGTTTGCTAAATTATAGCATAGATTTGAAA GACGGAAATTTTTTTTTGTTATTTTGATTCTTTCTGATTCAGAACCTGCG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGTTTCC ATTCCTGGGATAGAGAGCCCTGCCAAAGCCAACTCAGTCTCCTGTTATTG CAGAAATTTAAAGGTTACTTGAGCTGATTGATACCAATTAAAATAAAAGC ATCTACTGCCATTTTATTAAACGCCCTATTTAATCTCCACATCCCAAGTT CATTCTCTCTCTCTTTTAAGGCTATACATGGGCCTCAACATTCTCTCTTC TTCAGTATCAGCTGTCCTCATCCCTATTCAAAGTCAGAATGACTTGGAAT CTATTCAGGGCTGCTACTTAATTGGATGAAGAAAGTACTCTGTTGCATGC TAACCTCCCAGATTTGAATTAGAACCAAGGTCCTGAATCTACACAAGACC TTTTTCCCTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTT TTTGAATTTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTG (SEQ ID NO: 248) pARBI-644: ATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAAATAAAATCA 2541 chr15_2_ GGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGAGGTTTCAAT Exogenous_101 TAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAAATAAAGGAG CTCTGGCTTTAGGCCTTCTTCTGTTTATAGACAGTAAATTTTAATCCTCT GTCCCTGCAGACCAACTCAAAGCAGTAACCTTGGCTACCGTTGCCGCAGA AGAAACACACCCTGCAGATTTCCAGTTCTATATTCAGTCTTAGAAAATTG GTCATGTTGAAAGGGAAAAAACAATTTTACTTTGCCTCAGTTATTGACAC CAAGAAGCACTCCTCAGCCTGTTCAGAGGGGAAACAATGAGTCATTCATG CTGTCAGCCCAGGTGGTGCATGAATTCCAGACAGAGGCCGCTGAATTAAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCCGTGGAGG CGTCTCTCTGAGCAGAGCCCGCAATGCGCCTGCTTGGGGCTCCCTGCAGC CTCTGGGGGAGGCAGGGCGGCCCAGAGCAGGCCTGTGCTGGAAAGGAACG CGAAGCCCTGTAACCAAGCCTGTACCTCTGCAGTGCTAGTCCCAAGGGGC CTCCGAGCTGTTTGTCACCATGTGATTGGCTCAGGAGAGGGGTGGAGAAA TGAAAACACTCTGCCCAGGATATATTTAGTTGAAGTGCAGCTGGGGAAGT GCTTAAACAAGGGAGCTTTTGTCCTTATGTTGAAGTGTTTTTCTTAACTC CTCAAGGGTGAAAAACTTGAGCCACGTACTGATCCCATTCCCCCCCACCA CCCCCAATATATTTTCTCTTCTTTAGGAAATGCTCTTATTCTGAAACTTT AGAATTTTCTAGGGTTTGTTGCATAAGAGGAAACTGAATAA (SEQ ID NO: 249) pARBI-645: CTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTTTTTGAAT 2541 chr15_3_ TTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTGCTCTGTCGCCAGGCTG Exogenous_102 GAGTGCAGTGGTGTGATCTTGGCTCACTGCAGTCTCCAACTCTGGTTCAA GCAATTCTCCTGCCTCAGCCTCCGGGTAGCTGGGACTACAGGCATACACC ACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCAT AGTGGCCAGGATGGTCTCCATCTCTTGACCTCGTGACCTGACCCCCTCGG CCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCGCGCCCGGCCTCTT TTTGAATTTTTTTAAAAAAACACCTAAAGTTTAGGAAAGTATAAGAGGCC AAAGAAACAAGAGTTCAAAGAAACAAGAGTGTTATACACGCACACTTGCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGAAAGGTAGT AAAATATCTGTATAGTTCTGGCTGTCAAGCTTTTGGACTGAGATATGCGT AAGCAAGGCAAAAAGATCCCATAGTCCAGGAATATCAACCAGTCCAGTTT CCCAAGGAAACTAAAAGTAACTGAAAATGAGAAGGGTGCCATATAGGAAA ATTGAAGGTGGGGCATAATTATTAATACACTGCTTTGGAAATGCTGGTAT GGAAGATTCATATATGGACTTCAAAGCATACATGTCTTATACTTAGCTAT GGGAAAATTATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAA ATAAAATCAGGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGA GGTTTCAATTAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAA ATAAAGGAGCTCTGGCTTTAGGCCTTCTTCTGTTTATAGA (SEQ ID NO: 250) pARBI-646: TGTCTTCACGGCACGGCCCCCGCTTCACCAGCTGCACTGTTTGATGAGCT 2541 chr16_1_ TTGCAGGTCCCAGATCTTATAAGCTCATGGTGATTGATCCAAATGATGCA Exogenous_103 GAGGTCGGCCTAAAGTTAGAAGTGGGCCCCTCTCTGCCCCAAGACAGCCC TTCACCCCAATTCCATTCCCACAGTTTGGGCATCCACCCAGGCTGCCAAG CCAAGCGGGGGCTGCCCGGGTTAGCAGGGACCTGGCCATGGGCCTCCTCA GCTAGGGGCCGCCTCTCTGAGGAGTGGGTGCCCCGCCCCTCCGTGGGCCG CCTGGTTTCTCTTATTGGCAGCGTCTGTAGTCCCCTGGCTCTGTCACCCG CAGCTATTCTAGGCCTCTGGTTCCTTTCACTTTCTGCTCTGCGTCTTCCT GCCTCGGTGGTTCCCCACCATCCAGCCTGAGACCTCCCCGTTGCCCGCCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggggggcaggacagcaagggggaggattgggaagacaatagcag gcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGTG CCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGGG GGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAAA CTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGGG GAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAAC GGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTCC TTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTC GCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTC TAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCC TTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGC TTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGA TCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccaccA TGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTC GAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGG CGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCA CCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTAC GGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTT CTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCT TCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGC GACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGA CGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACG TCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAG ATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCA GCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACT ACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGAT CACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCAT GGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaat aaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcat tctagttgtggtttgtccaaactcatcaatgtatcttatTGGGTTTCTGT CTGCTCCTCTCCGTGGTGGCCGGCCCTGGCTCTGCCCCAAAGCCATGGAG AAGGCCAAATGCAGGCTGTAGAAAGGTCTGGGATCAGATCCCCCCATCCT TCCATGGCCACGTGACCGGGCCCGCCTCTTCCCTCTGAGCCTCACATCCT CATCTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAG GGGGTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCT GACTCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATG GGACCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAG AACAAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCT TGGGCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCAT (SEQ ID NO: 251) pARBI-647: CTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAGGGG 2541 chr16_2_ GTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCTGAC Exogenous_104 TCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATGGGA CCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAGAAC AAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCTTGG GCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCATATCTGTGAATGAGG CAGCTGGACTGAAGAATAGAGAGTCACAAAGCAGAGTGACACAAACTGGG CTACAGGAAACCCTGGAGGCCCTCGACCCAGGCTGGGGCCGGGGATGGTT CTGCAAAGCCTCTTGGGAGAGGGTTGCCTGAGCTGAGTCTCCAAACAGAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGCCT TAAGTCACGGGAGATGAGCCAGAGCAGTCCAGAGGGCACGGTCAGCACAT GCTAAGGTCCTGGGGCACAGAGTACAGGGCTTGAGAAGGGTTCCTCTTGC TCCATGTGACTTTCATCATCCAACAGCCTGTGGTGGCACTTGCCTGTATC CCAGCTATCTAGGAGGCTGAGGTGGGAGGATTGCTTGAGTCTGAGAGGTC GGGCTTGTTCTCCCGGTGTTGGCAGAGTCCAGAGGGAGCAAGTGGAAGCC ACAGGTGTCTTGAGGCCTAGGCTGAGATCTAGCACATCACCGCGTCACTT CATCCCTTCATTTCATCCTATTGGCCAAAGCAGCCCAATTCTAGGGATGG GGATCTAGACTCAACTTCTTGATGGGAGAAGTAGCAAAGTCACACTGCCA AGGGCAGGGACACAGGGAGGGATGAAGAGTTAGGAATGGTT (SEQ ID NO: 252) pARBI-648: AAGCCACCTCCCTGCTCTGTTGCTGGCTCTCCTTGAAGACAAGTGTTTTT 2541 chr16_3_ CAATTAACCAAAGCGGTGCATGGCAATGTGATAGGGGAATGAAACACAGC Exogenous_105 AACAGAATCAATGCCCCACGCTGGGCAATAGCCGACTTTCTGTTCGCTCC CATCCCTTCCTTCCCTCCCCGCCTCCTTCCCCTGCTCCTTCCATTCCACA AACATTTATTGAGCACCCGCTGTGTGCCAGCCACTGTTCTAGGCCCTGAA GACACAGAAGTGAACAAAAAAAAAGAGTCCCTGTGCACATCCTGGAGGGA CTTTCCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTATACAGTGTA TGGAGACAGTGGATAATAAAAGCTGTTTATGAGGCACTTTCTCTGAGCTG TTCCATGTGCTTCACTTATACTCATTCAGCTAATCCTCAGGACACCCCCG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGAAGTCAG TGATATTAGTCACAGAGGCCCAGAGAAGTGAAGTGACTTGCCCAAGGTCA CACAGCCAGCAAGAGGCCAAGCCCGGATTGAACCCCAGCCGCCTGGCTCT GGAGCCTGCAGCATAACCACAGCAGGGAACTGCCACCGGAGACAGACATC GACAGCCACTAGGAGATGTTAACCAACAGGCTTGTCTTCACGGCACGGCC CCCGCTTCACCAGCTGCACTGTTTGATGAGCTTTGCAGGTCCCAGATCTT ATAAGCTCATGGTGATTGATCCAAATGATGCAGAGGTCGGCCTAAAGTTA GAAGTGGGCCCCTCTCTGCCCCAAGACAGCCCTTCACCCCAATTCCATTC CCACAGTTTGGGCATCCACCCAGGCTGCCAAGCCAAGCGGGGGCTGCCCG GGTTAGCAGGGACCTGGCCATGGGCCTCCTCAGCTAGGGGC (SEQ ID NO: 253) pARBI-649: GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG 2541 EDF1_1_ TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG Exogenous_25 GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGTGACGGTG CTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCT TTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCGGACGCTgggccgggg ccacggaccgtggggcagggggctcggggaagggcaggcggggcctggga cagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACGGGG TTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACagg ggtgggaaggtggggggcggacccaggaggggatggacggacccaggagg cagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCA AGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGGGGGGAGGGG ATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAG (SEQ ID NO: 254) pARBI-650: ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG 2541 EDF1_2_ GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC Exogenous_26 GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCAAGAAGG GCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCTTTGCTGACTGAGG AGCGGCCGGGCCGGGCGGGGCGGACGCTgggccggggccacggaccgtgg ggcagggggctcggggaagggcaggcggggcctgggacagggcgcagggg acggggacaaggctggGGTGCCGGGGGCAGGACGGGGTTCGAAGGGCGGG GCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACaggggtgggaaggtgg ggggcggacccaggaggggatggacggacccaggaggcagggggCGGGCG ACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCAAGGGGCAGGCGAT AGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAGGGGATAGGGGCAGGGA CTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAGGAGGTG (SEQ ID NO: 255) pARBI-651: CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC 2541 EDF1_3_ TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA Exogenous_27 CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCTAAAG AGAAGATGTGCTTTATACACATCAGCTCCACTAGGACTGCTGCAAAACCA GGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAGGGCCCCTGGGGTACG CACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAGTGAGAGCCGGGCTGA CCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCAGGGGGGTGGAGCCCA CCCTCCCCGTGCTATCTGAACACCGGCCATCCCCCTCCCCAAACCCACAA CCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGTGGCCAGGTCCTTCTG CGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCACCTTGCCCACCTCCA GGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCCCGGTCCAGCTTGGCC GTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCCAGCAGC (SEQ ID NO: 256) pARBI-652: CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA 2541 FTL_1_ GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT Exogenous_2830 CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCGATGATG TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC GCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCACAACACGCGGCAGTCC ACACCGCTGCGTGGTCTTAGGGACGTATAGCTGTAAGAGCTAGGACAGGG TGCGGAGAGTGATAAATACAAGCTGTCACATGTCTTTGTGGCCTGGGCCT CTGACCCCCAACGACTCTTGGGAAATGTAGGTTTAGTTCT (SEQ ID NO: 257) pARBI-653: TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC 2541 FTL_2_ CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG Exogenous_29 CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCTCTCTCTG GTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCTCCAGCTGCGCACCTC CGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCGGTCGGGTAAACAGAG GGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCATTGTTGCCTCCATCT CTTCCCGTAGGGCTTCTATTTCGACCGCGATGATGTGGCTCTGGAAGGCG TGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAGCGCGAGGGCTACGAG CGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAGGA CATCAAGGTAACTAGTGTGTGGGTAATGGACTACATCTCCCAGCAGGCCG TGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTGTCGCGTGGGCTTCTG GGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACCGCTGGA (SEQ ID NO: 258) pARBI-654: CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT 2541 PTEN_1_ TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA Exogenous_31 GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCG CACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGA AGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGAC TTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAA CAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGG TGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCC GACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCC CGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACG AGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATC ACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagcttataa tggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttt tttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttat GCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTTATCAA ACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATG TTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATA TGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCT AGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTT TGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAG ATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAG TAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATGTATGTG TATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACATATTCAT (SEQ ID NO: 259) pARBI-655: GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA 2541 PTEN_2_ ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT Exogenous_32 CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatCGGGGCAAAT TTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGA GACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGAT CTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTT TTATTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATA ATATGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAG TCAAACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCC AGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTATACAATG TTATTATTAACTATAGTCACTATGCTGTCCAGTAGAGCTTCAGATCTTGT TCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCCCTGGAA (SEQ ID NO: 260) pARBI-656: ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG 2541 PTEN_3_ TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA Exogenous_33 CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAATGGCTA AGTGAAGATGACAATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGG ACGAACTGGTGTAATGATATGTGCATATTTATTACATCGGGGCAAATTTT TAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGAC AAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTG AGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTA TTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATAATA TGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAGTCA AACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCCAGG GTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTAT (SEQ ID NO: 261) pARBI-657: TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG 2541 PTPN2_1_ ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag Exogenous_34 tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct gagaaaaaaaagtcagttttgatcatttacaaccaaaaatcctaactaac acaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCTT ATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAACA AGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctctc tctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCTG GCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCt gacgactgtgccttctagttgccagccatctgttgtttgcccctcccccg tgccttccttgaccctggaaggtgccactcccactgtcctttcctaataa aatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggg gggtggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatATTGTGGAGA AAGAATCGGTGAGTAATATTTAATATTTACAACTTAGTATACTGTATGTG ATCATTAGCATATAAAGATTTTCATTTTGGGGCCAATATTCATTCCTTAG TTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAAAGTGTTTCTGTCCGGA AAAACTCATGTATCCTTTTCCTTTCTTAAGTATTTTTATAACAATTGCAG ACCTTTCATCTCCAAGATAGAAATACAATGGAATAAATATGGACTAGCAG TGACATATAGATCTTTGGAATCCCTAGGAATCCTTATTGACCTATTGTCA ATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTGTTCTACTTCAGATTTC TTACTTTATTCTACATTTCATAATTGCTGGTTTTTAATGATGATGAAAAT TTCCTAATCCACTTCTAATTAGATGTGGCAATGACATGCC (SEQ ID NO: 262) pARBI-658: CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT 2541 PTPN2_2_ TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT Exogenous_35 AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg accttggttcaatgctgggactgccacttactagctatgggatctttggt ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTATCCTCATA GAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAACAGATACAGAGATGTA AGCCCATGTAAGTACTTGTGGGTTTGTGTGCATGTGTATTTTTTGGTTTG TTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCTTGGGGTCAGTGTTGAT AAATACAGTAATTTTTTTCCTATTTACGTAAGACACGTTCTTTAAGAATT TAAAGGTGTAGAATAGTGGAAGGAAAAATAATTACCCATAATTATTTCAT CCTTCAAACATAGGCACCATTATTTTGGTGTATTTCCCACAACCTGTTTT TCTTATGCACAGTTTTCCTTTCTTTAAAATAATTGTAATTATAGATGTCT ATATAATATCCATATGTATTTCCTTTTCATATCATTCCATCCCCTTTGTA AGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGGTTTTTT (SEQ ID NO: 263) pARBI-659: ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT 2541 PTPN2_3_ CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT Exogenous_36 ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatCAAAGGAGTT ACATCTTAACACAGGCAAGTAATACGATACCACGCAAATGTCTGAAAATG ATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGGTAAAAGTATATCTTGA CTTCTTTTGGAAATGAAATGGTATTTCAGTTTTTTTCTGACGATGTAATG AATTATGGACATTATAAGGTTTTGAAGCTTTGAGTATTTAAGATAAAAGG CAAGTTATTTTTGATATTACACGTTCTGTGAAGGAAAATTCTTAGGAAAT GGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCTTACATTATATCTGACA CAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTTTCTCTTCCCATACCCT GTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTGTAGCTCCCCCTGCCTC GCATATATCTTCAGAGAGTACACCAAGCCCTGGATGGTGT (SEQ ID NO: 264) pARBI-660: CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC 2541 PTPN6_1_ GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG Exogenous_37 CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGTGTC CTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTGAACTG CTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCACCCCCGCCATTCCCA AGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCAGGGAGGCAGGGAGAC TGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCCCTCCCTGCACCAGCT GGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGGGACCTGGTGTCTCAG AGCCTAACCTACCACCCTTTCCACCTAACCCCGAGGAAGCCACAGAAAGC TGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCAACCCAGGTCCCACTG GAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTCGTGCAGGCCAGCTCT GTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGCCTGCCT (SEQ ID NO: 265) pARBI-661: CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT 2541 PTPN6_2_ GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT Exogenous_38 GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACGTTTCTT GTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAG TGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCA AGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGGGGAGCCTCTGCTGAG GCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGAGGGTCTGCCTGGGCT TGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTCAAGTCCTGTGAATGG CCTAATTTGGCTCCCCCCAGGGTGGACGCTACACAGTGGGTGGTTTGGAG ACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGAT TGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGGTCAGGGGTGGGC CCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCCAGATGT (SEQ ID NO: 266) pARBI-662: TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT 2541 PTPN6_3_ GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT Exogenous_39 TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTTCAC CGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGT CCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT CGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCCCGGGCATTTTGGCCA CTCTCTTGTGCCATCCAGGCCCTGAACCACTCATTCCTGGTTCCCCGTGG CAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAACCCCCACACTCCCCA TCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCCCCACCCAGGACCTCA GCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACCGACTGGCCTCACCGC CTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAA CTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG (SEQ ID NO: 267) pARBI-663: TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT 2541 PTPRC_1_ ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT Exogenous_40 ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCTTTG GATAATGCTAGTGCTTTTAATACCACAGGTTGGCACACAAAAGTTGTTAA CTTAAATATCAGGGAATGTCATTTAGAAAATTCTACAGTTATCAGTACAA CTTGTCTTTAAATTATTTGCACAGTTTCTAAGTATGTGATTTTATTCAAG TGCAGAAATTGCAGGAAATTAGTATCTGTGAAATATAGATCGACTGAAGT AATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAAAGAAGGGAAGCAAGA TCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTAGTATCCTCTGATCTA TACACACTCGCCATGATTCTCCCGCTTGGCTTCCCGCCACCTGGACAGAT GAGAATTTCCCTAGTTCAGAGATTATCAGTTCTACTCTCCTTGGAAGGTG TCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCACTCTAGA (SEQ ID NO: 268) pARBI-664: AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT 2541 PTPRC_2_ GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA Exogenous_41 TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACTGGTAAG AATTAATATTTATATTTTTACTAATTTTATTTTCTTGTTGCAAAGTTTAT ATATTTAACTACAATTTTCTATTATTAACACTGAAATTATTTTTAAGGAT AAATTTTATAATCATGAGTGATTCTTGACATTCACTTGTTCTTAAACTTT CTGCTTATACGTTATAGAGTTTAATAACTACCTAAACATGTTATTAAATT TGTATATATATTTTGTGTATAAATAGTAACTTTTCCCAAACTTGACAGTA AATCACACAACAGGTTTCTACTCTCTTTTAATATTTTAAGACTATAAAAA AATGCATTTAAATTAGATAACAAAATTTTATAGTCTGAAAGCAGGTTAAC AGCTGTCTATGTATGTTATAGATATGTAGATAACAGATTTGCATATGTCT ATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGGTATGCA (SEQ ID NO: 269) pARBI-665: CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA 2541 PTPRC_3_ TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA Exogenous_42 GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTCATAGGAA AAGACATAAATGAGGAAACTCCAAACCTCCTGTTAGCTGTTATTTCTATT TTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGTGGATTAATTAAATGC AGCGAACCAATATTTGTAGAAGGGTTATATTTTACTACTGTGGAAAAATA TTTAAGATAGTTTTGCCAGAACAGTTTGTACAGACGTATGCTTATTTTAA AATTTTATCTCTTATTCAGTAAAAAACAACTTCTTTGTAATCGTTATGTG TGTATATGTATGTGTGTATGGGTGTGTGTTTGTGTGAGAGACAGAGAAAG AGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTTGCTTTTCCTTTGTTT TTATGAAGAAAAAATACATTTTATATTAGAAGTGTTAACTTAGCTTGAAG GATCTGTTTTTAAAAATCATAAACTGTGTGCAGACTCAATA (SEQ ID NO: 270) pARBI-666: aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat PTPRCAP_1_ agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt Exogenous_43 ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg agggatgggggctgatctcacagggccagagcctggttgaccaaataagg ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatACCTTAGGGC TCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCG GAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgct gctcctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCC GTGACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGG GGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCA GGCCCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGG ATGAGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCT GACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCA GGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACG 2541 (SEQ ID NO: 271) pARBI-667: aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc 2541 PTPRCAP_2_ catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca Exogenous_44 gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGCTCC AGCTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCAC TGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACT ACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTG CTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGG GTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACT ATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAG CAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGA GGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAG GACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGT (SEQ ID NO: 272) pARBI-668: cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg 2541 PTPRCAP_3_ agtggtagggaggaggctggagggatgggggctgatctcacagggccaga Exogenous_45 gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCACCCGGCC CGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAG CCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACA ATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTC GCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGG AGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAG ACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAGGACCAGCGAGC GCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCTGCACGCCTTTGCTGG CAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTGGGGGCCAGGGCCTCC ATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCCCATCCC (SEQ ID NO: 273) pARBI-669: ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG 2541 RPS23_1_ GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA Exogenous_46 GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTGGCAT GATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCC TTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAG TCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAA CTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTAT TCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAA GTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAAC GTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGA CACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCAG CTATTGAACTTTATCGACTTGATAAAACTAAGGTGAAGAGA (SEQ ID NO: 274) pARBI-670: CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA 2541 RPS23_2_ GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC Exogenous_ CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA 47_48 GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCTTCGTACT GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACA GTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCCTTTTGGAG GTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAGTCCATTGC TCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAACTTACGAA TTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTATTCATTTGG GCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAAGTTGGTAA AATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAACGTTGGCCT GGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGACACAAACA CCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCA (SEQ ID NO: 275) pARBI-671: TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA 2541 RTRAF_1_ TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT Exogenous_49 GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTATGGAGATA ATGGTACGTTTTGTGGGGAATGTGTATTTTAAAGAGAGAGGAAAGATGGG AAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGTTTGTTTTGTCTAGTAC TATTTTACCTTTGGTTTATTCTTATCACAAGTTAAAAGCACTTTTATTGT CTTTCATTGGTGTTTATATATTTCTGTTAGAATTTGGAAATGGTGCCCTC TGGAGAAGGCTAATTGACTGTCTTCTCACAGAGTAACACTACTTTGATAA TATGGTCTGCACCTTAGCCTTTCAAATTAAATTGTTTTTAGTGTCCCAGA ATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGTAATTTCTCAAAAGACT GAAACATGTCTAATGCCAATATACATTAATACTCTATAGGCCAGAATATA TTACTTATGTTTACTGTCTTAGCACAGATACTTCTATGGT (SEQ ID NO: 276) pARBI-672: GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA 2541 RTRAF_2_ CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC Exogenous_50 CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTTGACG GCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAAGGTGAGGCGGC GGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCTCA GTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCCGC CGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTCTT CGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGGCA TGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTCTC TGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTCCA TGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGGGC CAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTG (SEQ ID NO: 277) pARBI-673: CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA 2541 RTRAF_3_ GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG Exogenous_51 GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGTGAGGCG GCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCT CAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCC GCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTC TTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGG CATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTC TCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTC CATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGG GCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTGAAGACTA GTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGGTGGAAG (SEQ ID NO: 278) pARBI-674: CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC 2541 SERF2_1_ CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC Exogenous_52 CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCGGTT AAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAG GTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACC AAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAG TCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCA CCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCG CCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCA AGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAG TACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTCC TCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGAATAGAG (SEQ ID NO: 279) DARBI-675: AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA 2541 SERF2_2_ GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC Exogenous_ CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG 53_54 AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGCGAG CTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGACTCGGTTAAGGGAAA GCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAGGTAGCCCC AGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACCAAGGGTTA TAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAGTCGTGAGG AGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCACCCTCCAA ATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCGCCTGCCCT CAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCAAGGGCAGG GAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAGTACTTTTG GCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTC (SEQ ID NO: 280) pARBI-676: TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT 2541 SLC38A1_1_ ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA Exogenous_55 ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGGGAAGTTCG TAATCTTTGGAGCCACCTCTCTACAGAACACTGGAGGTAAAAAGAACATG CTTTTCTTTACATAACTTGAAACTAATTCTGGTGGATGAGCGGCCACATG AATTTTAACATAATTCAAGCAGTTATCATCCTCATTGCTAAAATGGCACA GGGAAAGTAAAGCAGAGACAGCAGTCACTTATTTAAAGCCACAAATCCTG CTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTGACAGTTGGTCTAAGAA CGGGCTGATAACTTTTTATGTAGCTTGCAACATAAGCCTTCGTATCTTCT TTCTAAAAATGTTCTCATTTTCCTTCAGCAATGCTGAGCTACCTCTTCAT CGTAAAAAATGAACTACCCTCTGCCATAAAGTTTCTAATGGGAAAGGAAG AGACATTTTCGTAAGTTATAGACCATTITTTTATGATATA (SEQ ID NO: 281) pARBI-677: TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA 2541 SLC38A1_2_ TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC Exogenous_ AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA 56_57 TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTAGGCATG TCAGTTTTTAACCTAAGCAACGCCATTATGGGCAGTGGGATTTTGGGACT CGCCTTTGCCCTGGCAAACACTGGAATCCTACTTTTTCTGTGAGTATTGA CGTGCCGGTACTTTCCATTTTAAAACTGAACTTTTTGTATGTTTCTGTTA TTACATAGAAGAAATGTGAAATATTTATAAATAGTTTTTTTATTAACTTG GCTAAGTTACAAGTACATACTTTGATATTTATTGCTTGAGTGATTTTCCA AACTGTACCTAATGCTTACAACAAAGAGGAAGGAGAAAATCTTTTTATTA ATCAAAAATACTGAAATAAGCATTTGTGAAAAGGATTAAAACATTTGAAA ATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTGACTTTAAATCTCAGT TAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCACCACTT (SEQ ID NO: 282) pARBI-678: ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT 2541 SMAD2_1_ TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA Exogenous_58 AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatAAAGGATTGC CACATGTTATATATTGCCGATTATGGCGCTGGCCTGATCTTCACAGTCAT CATGAACTCAAGGCAATTGAAAACTGCGAATATGCTTTTAATCTTAAAAA GGATGAAGTATGTGTAAACCCTTACCACTATCAGAGAGTTGAGACACCAG GTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGAATTAAATGCCTGAACT TCAGTATATTTAAGTACTCTTGTGACCCAGGAAAATTTTAGTGTAAATTC TAATAAATTACCTTAAATTGTGCATATTATTTGGTGGTAATTAAAAtttt tttatttttaaaaatttttAATGAGAAAACATATCTGTTTCTTGGAATAG CATATGATTTGGCATGAAAGTGCATATCCAGGAAATCCTGTAGATTGGCA GTCTGCTCAGCGCTATGCTGATGTGCTTCTACATGTCCCT (SEQ ID NO: 283) pARBI-679: TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA 2541 SMAD2_2_ ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG Exogenous_59 ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGGAT ACAACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTGAATATTCTGCCC TCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGTATATTTTGAAAGACC TATATGGGGTTGCTTAGTATAATTTTGCCTAGGATGTTTCCTTAATGTAA AATAAGGCATAGCATTTAAAATATCTGCTTGCCAGTATAAAAAATATATT AAATGTTTCAGCTGATGTTTTAATCAATGCAATTCTAGTTTGAATCTTCT TTAAATTACTGTATCCCCTAAAGAATAATAATTTTGATAACTATATATTT ATTTTAGCTTGAGATCAGATTATAATCTGTTGTTGGCCTAATTTTTAAGT AGATACATGATGAGTTTTGCTAAATTTCTTGTTATCAGAATCTCATCTTT ATACTAATAAATACATACTTAATGAACCCCTTATATCACAA (SEQ ID NO: 284) pARBI-680: TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG 2541 SMAD2_3_ TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA Exogenous_60 AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGCCATTCA CGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAAGAAGTCAGCTGGTGGG TCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGCAGGAAGAAAAGTGGTG TGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTAAAGAAAACAGGACGAT TAGATGAGCTTGAGAAAGCCATCACCACTCAAAACTGTAATACTAAATGT GTTACCATACCAAGGTAAGTTTTGTTAGATCCCAGGTTTGATCAAATTAT GTCAAGGAATCTGAAGGAAAGTTACTGAATTTGTGTTCCTTTCAAGTTGC CTGTAAAAAGTGATGATTGAAATATGACTGTTTTTAACCTTGTATAAATT GTTTTTGCTAGCTGACTTGTTTTATAAATTATTTTCTTGAATAGTGAGGT TTAATCAAGCTAAATAAGATACTTAGATTTATTATCTTCA (SEQ ID NO: 285) pARBI-681: GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC 2541 SOCS1_1_ CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAG Exogenous_61 CCGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTC TCGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCC GGGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGA GGCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGC CGGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACC TGCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGC ACCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGTAGCACAC AACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACG GCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgc gcccgcggccgtgccccgcggtcccggccccggCCCCCGGCGACACGCAC TTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAG CGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACG GGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGC GACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTC GGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGG ATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTG (SEQ ID NO: 286) pARBI-682: GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC 2541 SOCS1_2_ CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC Exogenous_62 TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCGGCGGCCA GAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcg gccgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCA CATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTC CTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCA CGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCC GCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCC ACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAG CCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGG CGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGC (SEQ ID NO: 287) pARBI-683: CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG 2541 SOCS1_3_ TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC Exogenous_63 GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCGTTCG CACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTCCTGGACGCCTG CGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCACGAGCGGCTGC GCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCCGCCAGCGGAAC TGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCCACGAGCATCCG CGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAGCCGCGAGAGCT TCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGGCGCCGCGCCGC ATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCGGCCGCTGCAGGAGCT GTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCGAGAACCTGGCTCGCA TCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGCTCCTTC (SEQ ID NO: 288) pARBI-684: GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC 2541 SRP14_1_ AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG Exogenous_64 GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGACGCTGCC CGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCTCCGTCAGGAACTGGA AAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAATCCTCGTCCTGCCGC GTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGTCTCGAGTAACGCCTG AGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCCATACCTGCTCGCTCT CCAACAACACCATCGCGGCGACGCTGGCTCGACTCCCTCCGCTTAAGCCC CTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGGGCGGGACTTCCGCTA CTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTTCCACCAATCCCGGC CTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCGCGCCCTGGGACGTC CGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCTGGGTC (SEQ ID NO: 289) pARBI-685: GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC 2541 SRP14_2_ TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG Exogenous_ CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC 65_66 CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGTACTGTG GAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGG GAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTTCTAAGGCTGTCTTTT GAAATGTAAAGACTTGAACTTAACAGAGGATGGGGCGTTTCTGAACCAGG CTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCTATTTTTGAGACCAGG ACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAATAAAATAAGAAGGTA GAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTTGTGGAAATGAAAGTA GCATATTGGTCCTTATTCGTAGTACTGTAAGGAGCAGCTGGCATAAATAT TTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCAATAAGCAGTTTCTTG GTACCAGGTGATGCTATTATTTCCTTATCTTTGTGGTTCAC (SEQ ID NO: 290) pARBI-686: CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG 2541 SRSF9_1_ AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG Exogenous_67 CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGGAACC TTCCGACCGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTAC GGCCGCATCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTT CGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccc tctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccc agggctcccctccccccggcctcccctccccccgcctccgcgcagacccc tcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGC CCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAA TATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGC CTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCC (SEQ ID NO: 291) pARBI-687: TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT 2541 SRSF9_2_ GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT Exogenous_68 CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatACTTATGGAG GTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGGGCCTCCTACAAGAAGA TCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCCTTTCAAACAGaatgag atgatacatgtaaaatacttaacacagagtctgtcttccaagaaatgata gctgttattcttCAGTGCATGGGACACGGGGGCTTTCTTTTCAATAGCCT GTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAAAGTATCCTGCAAATGA AATTGCGCTGGGAGTGCAGCCTTGGAAGAACATAACCATATTTCTTGTAA AGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATGGGAAAACTTGAGCTAC AATTCTAAAGATGCTTCTTTTGGAATATACTTGGCATCAGACATGGTAGA AAGGCATTCAAGGAGCCAGATTTGAACAACTTACCCAGCC (SEQ ID NO: 292) pARBI-688: GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG 2541 SRSF9_3_ GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG Exogenous_69 CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGTGCGCTTC GAGGACCCCCGGTGAGGcccccgcgcccctgccctctcctcctcggtgcc tgaggcccccgccttccctgctgtcccctcccccagggctcccctccccc cggcctcccctccccccgcctccgcgcagacccctcaCGGCGCCCCCTCA CGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGC GCCGTCGTCACTTCCTTTATTTTTATTATTCCAATATTTTACTTAGAAAC CCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCCTGCACCGGCCTCGGG GGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGGGCAGCACCGTAGGGG GAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTCGCCCTTCCCGCTCGC CTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAGCAAGCT (SEQ ID NO: 293) pARBI-689: GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA 2541 SUB1_1_ GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC Exogenous_70 CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTTCTAAAC AGAGCAGCAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTAtt ttttttttttttttttttgacatggagtcatgctctgtcacccaggctgg agtgcagtggcgccatctcggctcactgcaacctcagcctcctgagttca agcagttctctgcctcagcctcccgagtagctaggattacaggcatccgc caccagacctggctaatttttgtatttttagtagagatggggtttcacca tcttggccaggctggtcttgaactcctgaccttgtgatccaactgcctca gcctccaaaagtgctgggtttacaggtgtgagccaccatgccttgccAAA GTTGGCTGTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAA GAATGTTAAAAGTACTATGATCTGATAATTGCCTAATATG (SEQ ID NO: 294) pARBI-690: ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA 2541 SUB1_2_ TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG Exogenous_71 TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAAGAGGAAA AAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAGACAGGTGAGAC TTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGATA ACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACATG GAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTC ACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTCCC GAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTGTA TTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT CCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTACA GGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTT (SEQ ID NO: 295) pARBI-691: AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC 2541 SUB1_3_ TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT Exogenous_72 CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACAGGTGAG ACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGA TAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACA TGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGC TCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTC CCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTG TATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAA CTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTA CAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTTAGATTCA GAGGAATTATTATCTGGCTTGATCTGAAGAATGTTAAAAGT (SEQ ID NO: 296) pARBI-692: CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG 2541 TET2_1_ CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC Exogenous_73 ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTCGGGGTA AGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACCAAATGTCTCCGATTT GAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCCAAGAAAATGCAGTTA AAGATTTCACCAGTTTTTCAACACATAACTGCAGTGGGCCTGAAAATCCA GAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAGTGCTAATTACCATGA CAAGAACATTGTATTACTTAAAAACAAGGCAGTGCTAATGCCTAATGGTG CTACAGTTTCTGCCTCTTCCGTGGAACACACACATGGTGAACTCCTGGAA AAAACACTGTCTCAATATTATCCAGATTGTGTTTCCATTGCGGTGCAGAA AACCACATCTCACATAAATGCCATTAACAGTCAGGCTACTAATGAGTTGT CCTGTGAGATCACTCACCCATCGCATACCTCAGGGCAGATC (SEQ ID NO: 297) pARBI-693: AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA 2541 TET2_2_ AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA Exogenous_74 GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatCATACCTCA GGGCAGATCAATTCCGCACAGACCTCTAACTCTGAGCTGCCTCCAAAGCC AGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATGATGCTGATAATGCCA GTAAACTAGCTGCAATGCTAAATACCTGTTCCTTTCAGAAACCAGAACAA CTACAACAACAAAAATCAGTTTTTGAGATATGCCCATCTCCTGCAGAAAA TAACATCCAGGGAACCACAAAGCTAGCGTCTGGTGAAGAATTCTGTTCAG GTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGCTCTGAACGGTATTTA AAACAAAATGAAATGAATGGTGCTTACTTCAAGCAAAGCTCAGTGTTCAC TAAGGATTCCTTTTCTGCCACTACCACACCACCACCACCATCACAATTGC TTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCTCAGCTT (SEQ ID NO: 298) pARBI-694: GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC 2541 TET2_3_ CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC Exogenous_75 CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatTTTCACCAAG CGGAATCCCATCTAAAACGTAATGAGGCATCACTGCCATCAATTCTTCAG TATCAACCCAATCTCTCCAATCAAATGACCTCCAAACAATACACTGGAAA TTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCTTACACCCAGAAAACAA CACAGCTGGAGCACAAGTCACAAATGTACCAAGTTGAAATGAATCAAGGG CAGTCCCAAGGTACAGTGGACCAACATCTCCAGTTCCAAAAACCCTCACA CCAGGTGCACTTCTCCAAAACAGACCATTTACCAAAAGCTCATGTGCAGT CACTGTGTGGCACTAGATTTCATTTTCAACAAAGAGCAGATTCCCAAACT GAAAAACTTATGTCCCCAGTGTTGAAACAGCACTTGAATCAACAGGCTTC AGAGACTGAGCCATTTTCAAACTCACACCTTTTGCAACAT (SEQ ID NO: 299) pARBI-695: AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG 2541 TIGIT_1_ CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC Exogenous_76 AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACGGGGAAC ATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTC CACCACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTC TGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAG GATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGAC CGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGATG GGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATT CCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATG CAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATTTG AATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCC (SEQ ID NO: 300) pARBI-696: GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA 2541 TIGIT_2_ GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG Exogenous_77 GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTGGGGTGG CACATCTCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGG CCTCACCCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCA TCTATCACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAG GTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCT CTCCCTCTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTT CTCAATTCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACT GATGCCGAGGCCTCACCCAGACCAATTCAATCAGAATCCCTAATAGCAGA GCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGGTGATTCTAATGGGCA GCCAATACTGAGAACCACTGTTCTTATGTAAGAAGCACATC (SEQ ID NO: 301) pARBI-697: CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA 2541 TIGIT_3_ TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT Exogenous_78 GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca ttctagttgtggtttgtccaaactcatcaatgtatcttatACGGCACAAG TGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAAT GCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAG (SEQ ID NO: 302) pARBI-698: TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG 2541 TRAC_1_ TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT Exogenous_79 ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatATCCAGAAC CCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTC TGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTA AGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCT ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGA (SEQ ID NO: 303) pARBI-699: GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC 2541 TRAC_2_ TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA Exogenous_80 ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatAGAGACTCT AAATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAAC AAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTG TGCTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGG AGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTAT TCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCT TCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTC TGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCA TTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGC AGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAG (SEQ ID NO: 304) pARBI-700: TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT 2541 TRAC_3_ GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT Exogenous_81 AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGGTGAG GGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCAT CCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAA AGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTT GTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGC CTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAAC GAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGT GTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCAT GTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTA CACTCATATTACACCCCAATCCTGGCTAGAGTCTCCGCACC (SEQ ID NO: 305) pARBI-701: ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC 2541 TRAC_4_ TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC Exogenous_82 TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatATGAGGTCT ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACAC GGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAG CCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGT TTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTT (SEQ ID NO: 306) pARBI-702: TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG 2541 TRAC_6_ GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC Exogenous_84 TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatTTTAATCTG CTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGAGGGGCCTTGAAGCTG GGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCATCCTAAGCTCTGAGA GCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAAAGCCTGAGCCCACC AAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTTGTGCAATAATAATG GCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGCCTCAGTTGCACTTC TCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAACGAAGAAACTGAGGC CCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGTGTACACCACATGCC TTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCATGTCCTCTCTCCCCA GTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTACACTC (SEQ ID NO: 307) pARBI-703: CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC 2541 TRAC_ ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT Exogenous_83 GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGTAAGGGC AGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTT CTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTC TCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGA GCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGA GAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAG TTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCT AGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTCTCCTTATTTCTCCCT GTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCAGTCTCACGCAGTCAC TCATTAACCCACCAATCACTGATTGTGCCGGCACATGAATG (SEQ ID NO: 308) pARBI-704: TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG 2541 TRIM28_1_ GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG Exogenous_85 CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGAGAGGGAG CCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCC CGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCG ACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTC TGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGA GGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATAC GAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG AGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTCGCTGCGGGATAATGG TCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCCATAACCTGGGTGGGA ACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAAGTGGTG (SEQ ID NO: 309) pARBI-705: TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC 2541 TRIM28_2_ ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA Exogenous_86 CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatACCAAGGAC CATACTGTGCGCTCTACTGGTACATGAGGCTGAGGGGGGCTGTTGGAGTT GTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGATGTTGGTTGCATCTGG TGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCCCGAAGGGCCCGAGGG CAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGTGTGTAGTCTCTAGGG CCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGGAGACCTTAATGTGCT GCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCAGGGAGTTGTCAGACC TGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAAAGGCATGGTGTGAAG GGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCTGGTATAAGATGCTGC TAGGGAAAGTAGACTGTGGGTCCATGGATTATAAGTGATGA (SEQ ID NO: 310) pARBI-706: GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC 2541 TRIM28_3_ GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG Exogenous_87 TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc attctagttgtggtttgtccaaactcatcaatgtatcttatGGCGGCGAA AAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGCCTCTGCCTCAGCCGC GGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGCTGGAGCTGCTGGAGC ACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAGAGGGAGCCCCGCCTG CTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCCCGCGGCCCC CGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCG GTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTCTGCCTTTGA TTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGAGGATGGGGG CCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATACGAACGTGGG TTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG (SEQ ID NO: 311) 

1. A method of editing a cell having chromosomal DNA, comprising inserting at least one sequence comprising a transgene within a safe harbor locus in the chromosomal DNA of the cell, wherein the safe harbor locus is at any one or more of an sgRNA target loci selected from: chr11:128340000-128350000, chr15:92830000-92840000, chr10:33130000-33140000, chr10:72290000-72300000, chr11:65425000-65427000 (NEAT1), chr16: 11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, chr9:7970000-7980000, APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, or TRIM28.
 2. The method of claim 1, wherein the sgRNA target locus is chr11:128340000-128350000 or chr15:92830000-92840000.
 3. The method of claim 1, wherein the sgRNA target locus comprises an integration site comprising a start coordinate of chr11:128342576.
 4. The method of claim 1, wherein the sgRNA target locus comprises an integration site comprising a start coordinate of chr15:92831131.
 5. The method of claim 1, wherein the at least one sequence is operatively linked to an endogenous promoter.
 6. The method of claim 1, wherein the at least one sequence is operatively linked to an exogenous promoter.
 7. The method of claim 6, wherein the exogenous promoter is an EF1α promoter.
 8. The method of claim 1, wherein the cell is a natural killer (NK) cell, an induced pluripotent stem cell (iPSC), a human pluripotent stem cell (HSPC), a T cell, a CD8+ T cell, or a T cell progenitor cell.
 9. The method of claim 8, wherein the cell is a T cell, a CD8+ T cell, or a T cell progenitor cell.
 10. The method of claim 8, wherein the cell is a CD8+ T cell.
 11. The method of claim 13, wherein the transgene encodes a protein, a therapeutic agent, a cancer-specific therapeutic agent, a T-cell receptor (TCR), a Prime Receptor (primeR), or a chimeric antigen receptor (CAR).
 12. The method of claim 1, wherein the transgene encodes a chimeric antigen receptor (CAR).
 13. The method of claim 1, wherein the transgene encodes a T-cell receptor (TCR).
 14. The method of claim 1, wherein the transgene encodes a Prime Receptor (primeR).
 15. The method of claim 1, wherein the transgene encodes an shRNA, an miRNA, or an siRNA.
 16. The method of claim 1, wherein the at least one sequence is inserted using a homology-directed repair or a homology independent targeted insertion.
 17. The method of claim 1, wherein the at least one sequence is inserted using one or more guide ribonucleic acids (gRNAs) and one or more Cas9 endonucleases, optionally wherein the one or more gRNAs comprises any one of SEQ ID NOS: 1-120.
 18. The method of claim 17, wherein the one or more gRNAs comprises SEQ ID NO:
 94. 19. The method of claim 17, wherein the one or more gRNAs comprises SEQ ID NO:
 102. 20. A guide ribonucleic acid (gRNA) for editing a cell at a safe harbor locus, wherein the gRNA comprises any one of SEQ ID NOS:1-120.
 21. An ex vivo method of obtaining an engineered cell or population thereof, comprising: a. obtaining a cell; and b. genetically modifying the cell by inserting at least one sequence encoding a transgene within a safe harbor locus, wherein the safe harbor locus is at any one or more of an sgRNA target loci selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, chr9:7970000-7980000, APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, or TRIM28. 